dynamin-related protein
Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action
... Mitochondria undergo dynamic changes to maintain function in eukaryotic cells. Insulin action in parallel regulates glucose homeostasis, but whether specific changes in mitochondrial dynamics alter insulin action and ...
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Dynamin-related protein 1 is involved in micheliolide-induced breast cancer cell death
... Abstract: Dynamin-related protein 1 (Drp1) is a newly discovered therapeutic target for tumor initiation, migration, proliferation, and ...its related signaling pathway pave a new way to ...
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Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone
... Mitochondria play an important role in the production of energy within cells, and are essential in the regulation of cellular life and death. In most healthy mammalian cells, mitochondria exhibit tubular, reticular, or ...
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Downregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related-protein 1
... mitochondrial dynamin-related protein 1 (Drp1), a mitochondrial fission mediator, by studying both sorted SP cells from NPC cell lines and gene expression analyses in NPC ...stemness, ...
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Phytophthora infestans RXLR WY Effector AVR3a Associates with Dynamin Related Protein 2 Required for Endocytosis of the Plant Pattern Recognition Receptor FLS2
... GTPase dynamin-related protein (DRP) ...mammals, dynamin is a five-domain protein consisting of a GTPase domain, an unstructured middle domain, a Pleckstrin-homology domain, a GTPase ...
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SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
... Severe ischaemia causes cell death through cytochrome c release into the cytosol, which leads to caspase cleavage and apoptosis. Cytochrome c can be released by mitochondrial fission (Wilson et al, 2013) and/or via ...
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Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure
... gene Dynamin-related protein 1 (Drp1) underlies the Python mouse model of monogenic dilated car- ...Drp1 protein function and to define the cellular sequelae leading to heart failure in the ...
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Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis
... pro-apoptotic protein Bax from the cytosol to the mitochondria is a crucial step in DNA damage-mediated apoptosis, and is also found to be involved in mitochondrial ...
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Peroxisome proliferator-activated receptor-gamma dependent pathway reduces the phosphorylation of dynamin-related protein 1 and ameliorates hippocampal injury induced by global ischemia in rats
... neuronal death in the hippocampal CA1 subfield [18, 19]. In this work, concomitantly with heightened protein oxi- dation, p-Drp1(Ser616) expression was increased (Fig. 2). It was known that Drp1 mediates ...
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Phosphorylation Regulates the Endocytic Function of the Yeast Dynamin-Related Protein Vps1
... of dynamin-1 in endocytosis is the best-characterized role of this protein ...family. Dynamin-1 has been proposed to act largely in a mechanical way to encircle the necks of invaginated endocytic ...
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Genetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury
... of dynamin-related protein-1 (DRP-1) and mitochondrial fragmentation induced by I/R-induced AKI, which led to antiapoptotic and renoprotective effects ...
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Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
... (S616) protein expression in glomerular ...Drp1, dynamin-related protein 1; TEM, transmission electron micrograph; Mid51 and Mid49, mitochondrial dynamics proteins of 51 and 49 kDa; Fis1, ...
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Calcium signaling around Mitochondria Associated Membranes (MAMs)
... As described above, mitochondria and endoplasmic reti- culum networks are fundamental for the maintenance of calcium homeostasis. Recently, different studies have documented the crucial role that MAMs play in intra- ...
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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
... inhibitors. Dynamin-related protein 1 (Drp1), a critical mitochondrial fission protein, translocated to mitochondria early during tubular cell injury, and both siRNA knockdown of Drp1 and ...
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Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
... can ubiquitinate itself in concert with its many mitochon- drial substrates. The PINK1 induced phosphorylation of Ub conjugated to Parkin substrates can trigger further cy- cles of Parkin recruitment and activation. This ...
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Ebola Virus Glycoprotein Toxicity Is Mediated by a Dynamin-Dependent Protein-Trafficking Pathway
... GTPase dynamin. Through its interaction with dynamin, GP disrupts the normal intracellular trafficking of cell surface proteins that are essential for cell attachment, viability, and immune ...to ...
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The Matrix Protein of Vesicular Stomatitis Virus Binds Dynamin for Efficient Viral Assembly
... M protein of VSV (Indiana, Orsay strain) was fused to the DNA-binding domain of LexA and used as a bait to screen a nerve growth factor-induced PC12 cell (rat adrenal pheochromocyta cell line) cDNA library in ...
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Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis
... actin-capping protein gelsolin (81) increases the second ...reintroducing dynamin 2 into these cells (Figure 8, D and E), suggesting a specific causal relationship between dynamin 2 and actin ...
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Reovirus Uses Multiple Endocytic Pathways for Cell Entry
... of dynamin-dependent endocytosis, as well as by genistein and dominant-negative caveolin-1, which block caveolar ...both dynamin-dependent and dynamin-independent endocytic pathways during cell ...
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The role of dynamin related proteins in vacuole biogenesis in fission yeast (Schizosaccharomyces pombe) : a thesis presented in partial fulfillment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Palmerston North, New Zealand
... In the fission yeast, Schizosaccharomyces pombe, the dynamin-related proteins DRPs Vps1 and Dnm1 act redundantly in peroxisome biogenesis Jourdain et al., 2008 but nothing is known about[r] ...
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