E-cadherin gene
Original Article Correlation between methylation of E-cadherin gene and malignancy of prostate cancer
... of E-Cadherin methylation also occurs in breast cancer [20] and skin squamous cell carcinoma [21] besides prostate cancer but not in normal tissues, suggesting the satisfactory specificity of ...
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E Cadherin exon 4 5, exon 7, exon 8, exon 9 and exon 16 mutations in sporadic infiltrating ductal carcinoma of the breast
... in E–cadherin exon 7, ...the E–cadherin–mediated cell–cell adhesion and be at least partly responsible for the weak intercellular adhesiveness and scattered histological pattern of the ...
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E cadherin expression in primary carcinomas of the breast and its distant metastases
... of E-cadherin in the pathogenesis and progres- sion of invasive lobular carcinoma is ...of E-cad- herin protein in the cytoplasm of the neoplastic cells, with no membranous ...that ...
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E cadherin intron 2 contains cis regulatory elements essential for gene expression
... to E-cadherin gene expression during development by crossing of Ecad-In2flox mice to a Cre-deleter ...Reporter gene activity of Ecad-In2flox and Ecad-In2floxdel mice was monitored by X-gal ...
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Tumor suppressor gene E-cadherin and its role in normal and malignant cells
... (E)-cadherin gene CDH1 maps to chromosome ...length gene by using recombinant lambda phage, cosmid and P1 phage ...The gene they cloned encompasses 16 exons and spans a region of ~100 ...
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<p>Histone deacetylase inhibitors reinforce the phenotypical markers of breast epithelial or mesenchymal cancer cells but inhibit their migratory properties</p>
... of E-cadherin, is followed by the gain of a mesenchymal phenotype characterized by the expres- sion of N-cadherin, vimentin and fi ...14,15 E-cadherin (E-cad), the product of the ...
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Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression
... and E-cadherin gene ...to E-cadherin promoter ...to E-cadherin promoter, but also promote its promoter ...regulate E-cadherin ...inhibit ...
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Original Article Association between E-cadherin (CDH1) polymorphisms and pancreatic cancer risk in Han Chinese population
... the E-cadherin gene (CDH1) located on chromosome ...adhesions, E-cadherin is also thought to be involved in intracellular signaling in normal epi- thelial cells, since downregulation of ...
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Low frequency of E cadherinalterations in familial breast cancer
... If E-cadherin functions as a classical tumour suppressor gene, then loss or inactivation of the remaining normal E-cadherin allele would be an important event in tumouri- genesis in ...
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E Cadherin Dysfunction and Cancer
... 1. E-cadherin dysfunction and ...of E-cadherin is to regulate cellular adhesion and motility, and therefore acts as an invasion suppressor system (stage ...for E-cadherin ...
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The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review
... have been some studies describing the methylation status of CDH1 in GC; however, the roles of methylation of CDH1 in GC and clinical significance have not been thoroughly investigated. In this meta-analysis, we mainly ...
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G9a interacts with Snail and is critical for Snail mediated E cadherin repression in human breast cancer
... G9a interacts with Snail and forms a complex with Snail and DNMTs. DNA methylation is catalyzed by DNMT1, DNMT3a, and DNMT3b (19). It has been shown that G9a can associate with DNMT1, DNMT3a, and DNMT3b (37, 40). The ...
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The role of adhesion molecules in the migration of Langerhans cells
... u n d isp u ted that lym phoid and cDC are m ore potent at antigen presentation th an non-lym phoid DC, recent experim ents involving in vitro m atu ratio n of DC have challenged the hypothesis that cDC lose their ...
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Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth
... and E-cadh siRNA-treated OAW42 cells grown in Matrigel® for 6 ...or E-cadherin siRNA-treated OVCAR5 ...panel: E-cadherin levels in OVCAR5 cells after 5 days of culture. d. ...
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Effect of butyl phthalide on serum cytokines, soluble apoptosis factors and antioxidant molecules in patients with vascular dementia
... invasion gene mRNA expression was analyzed at last in the study, and it was found that serum galectin-3 and midkine levels in patients with thyroid cancer were directly correlated with proliferation genes ...
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P120 regulates beta-catenin nuclear translocation through E-cadherin endocytosis in ventilator-induced lung injury
... or E-cadherin siRNA were subjected to 20% cyclic stretch for 2 or 4 ...of E-cadherin, which induced β-catenin translocation into the nucleus, a key event in lung injury progress and ...of ...
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ERBB2 mutations associated with solid variant of high-grade invasive lobular breast carcinomas
... With the advent of massively parallel sequencing, mutations in the sequence of the ERBB2 gene were found in a limited fraction (<1%) of breast cancers [12]. In vitro functional characterization of these ...
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Effect of hyperthermia perfusion chemotherapy combined with systemic chemotherapy on the expression and secretion of malignant molecules in advanced bladder cancer
... proliferation gene expression in bladder cancer lesions before and after chemotherapy showed that Livin and Bcl-2 expression in lesions decreased whereas Bad, LRIG3 and Beclin1 expression increased after ...
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TRIM28 is overexpressed in glioma and associated with tumor progression
... Results: We found that TRIM28 was expressed at significantly higher level in glioma tissues than in non-tumor brain, and TRIM28 expression correlated significantly with tumor malignancy. Furthermore, TRIM28 higher ...
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Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells
... targeted gene knockout mice ...targeted gene expression via site-specific DNA and histone demethylation [9, ...regulate gene expression at the transcriptional level, a complex network of DNA ...
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