E2F-1
E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
... express E2F-1/wt and E2F-1/mutant genes as described ...CMV E2F-1 is identical to Linker CMV T [18] except that the large T antigen gene from simian virus 40 was replaced by a ...
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Expressions and clinical significances of c MET, p MET and E2f 1 in human gastric carcinoma
... of e2f-1, which might transcriptionally regulate down several tumor- suppressing genes and apoptosis-related ...such, e2f-1 might potentially inhibit tumor cells and shed new light on the ...
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Induction of the Cellular E2F-1 Promoter by the Adenovirus E4-6/7 Protein
... the E2F family and mediates the cooperative and stable binding of E2F to a unique pair of binding sites in the Ad5 E2a promoter ...of E2F DNA binding activity strongly correlates with increased E2a ...
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Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.
... 8 0022-538X/94/$04.00+0 Copyright C 1994, American Society for Microbiology Heterodimerization of the Transcription Factors E2F-1 and DP-1 Is Required for Binding to the Adenovirus E4 OR[r] ...
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Adenoviral delivery of E2F 1 directs cell cycle reentry and p53 independent apoptosis in postmitotic adult myocardium in vivo
... Moreover, E2F-1 expression or function would pre- sumably need to be ...by E2F-1, arrhythmogenic foci are a likely explanation for mortality here, but systemic ef- fects cannot be ruled out; a ...
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Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1.
... American Society for Microbiology Analysis of p107-Associated Proteins: p107 Associates with Form of E2F That Differs from pRB-Associated E2F-1 NICHOLAS DYSON,'* MARLENE DEMBSKI,' ALI FA[r] ...
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Mutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1.
... These results strongly suggest that Rb interaction with the hE2F-1/ hDP-1 heterodimer requires the carboxy-terminal domain amino acids 409 to 426 of E2F-1 in conjunction with the conserv[r] ...
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E2F-1 has dual roles depending on the cell cycle
... putative E2F–binding sites in rela- tively small fragments of genomic DNA suggests that E2F-binding sites regulate gene expression in differ- ent ways in different promoter contexts [11] [14, ...the ...
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PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer
... All female BALB/c nude mice aged 5 weeks used in this study were purchased from Model Animal Research Center of Nanjing University. To assess the function of PEG10 in vivo, fresh cancer cells (1 × 10 6 per mice) ...
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Characterisation of a cellular transcription factor which co-ordinates cell cycle events with transcription
... and E2F-1 were able to heterodimerise. Thus, both DP-1 and E2F-1 were tested for binding to the E2F site or E2a promoter either separately or ...the E2F site poorly ...
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Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells
... cause E2F-1 ...prevent E2F-1 from proteosomal degradation due to RPL11 ...of E2F-1 prevents activation of cell cycling and sensitizes cells to DNA damage-induced cell death ...
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E2F Proteins Are Posttranslationally Modified Concomitantly with a Reduction in Nuclear Binding Activity in Cells Infected with Herpes Simplex Virus 1
... of E2F. Free E2F upregulates the transcription of genes involved in S phase and cell cycle ...virus 1 stabilizes cyclin D3 early in infection and that early events in viral replication are sensitive ...
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Activation of Notch1 signaling alleviates dysfunction of bone marrow-derived mesenchymal stem cells induced by cigarette smoke extract
... Abstract: Bone marrow-derived mesenchymal stem cells (BM-MSCs) are considered attractive therapeutic agents for the treatment of COPD. However, little is known about the impact of Notch on the proliferation, migration, ...
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Sunspot, a link between Wingless signaling and endoreplication in Drosophila
... Drosophila E2F-1 ( dE2F-1 ) and PCNA expression, and positively regulates the proliferation of imaginal disc cells and the endoreplication of salivary gland ...
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Expression of the E2F family of transcription factors during murine development
... that E2F-1 (KH-95)-reactive species exhibit an expression pattern which is diametrical to other E2F-1 species and to other E2Fs suggests that phosphorylation may be an important regulatory ...
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Hes 6, an inhibitor of Hes 1, is regulated by 17β estradiol and promotes breast cancer cell proliferation
... activator E2F-1 is an important cell-cycle regulator, stimulating the G 1 /S-phase transition by activating the transcription of other cell-cycle genes ...tified E2F-1 as a crucial ...
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The E4-6/7 Protein Functionally Compensates for the Loss of E1A Expression in Adenovirus Infection
... stable E2F DNA binding to the viral E2a promoter with increased expression of E2 gene products and the pro- duction of infectious ...that E2F induction by E4-6/7 might have an Ad infection under more ...
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E1A 12S and 13S of the transformation-defective adenovirus type 12 strain CS-1 inactivate proteins of the RB family, permitting transactivation of the E2F-dependent promoter.
... dissociate E2F from retinoblastoma-related protein-containing complexes, as judged from gel shift experiments with purified 12S and 13S proteins from transfection experiments with an E1A expression vector or from ...
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Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
... of E2F-1 in the regulation of RRM2, siRNA was used to knockdown protein ...of E2F-1 siRNA was sufficient to significantly reduce E2F-1 protein levels (Figure ...of ...
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The predictive value of lncRNA MIR31HG expression on clinical outcomes in patients with solid malignant tumors
... In this study, the association between prognosis and MIR31HG expression were reported in twelve studies. Eleven studies were included for OS meta-analysis. As the result of meta-analysis exhibited obvious heterogene- ity ...
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