Early growth response factor-1
Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs
... and growth factors leading to abnormal lung development ...necrosis factor (TNF)-α, transforming growth factor (TGF)-β 1 , nuclear factor (NF)-κB and inter- feron-γ ...in ...
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Suppression of Transcription Factor Early Growth Response 1 Reduces Herpes Simplex Virus 1-Induced Corneal Disease in Mice
... Results for VEGF-A were very similar to those for FGF-2 (Fig. 4C). In wild-type mice, HSV-1 infection enhanced corneal VEGF-A expression, particularly from days 7 to 14 p.i., with levels being significantly higher ...
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Lytic HSV 1 infection induces the multifunctional transcription factor Early Growth Response 1 (EGR 1) in rabbit corneal cells
... time-course study revealed that detectable levels of Egr-1 protein were present at 24 hours post infection, and similar levels were detected at 48 and 72 hours post infection (Figure 1B). Our data also indicated ...
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Low pH results in co ordinate regulation of gene expression in oesophageal cells
... the early growth response gene family, EGR3 and EGR4, were induced by low pH ...immune response genes, an increased expression of decay accelerating factor (DAF) was observed, which has ...
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Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta
... To our knowledge, the present study is the first systema- tic analysis of regulation by TGF b on gene expression of its own receptors and Smads, in human articular chon- drocytes. Our study shows that TGF b exerts a ...
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Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice
... Egr-1 and then transfected the stable cell clones with plasmids con- taining the promoters of viral immediate-early genes ICP4, ICP27, or ICP22/47, all linked to a luciferase reporter gene. The promoter of ...
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A gene therapy induced emphysema model and the protective role of stem cells
... endothelial growth factor receptor 2 and tumor growth factor β-1, and down-regulating inflammatory response, cell apoptosis and excessive pro- tease expression ...[28,29,31]. ...
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PlGF mediates neutrophil elastase-induced airway epithelial cell apoptosis and emphysema
... lungs. Early growth response gene (Egr)-1 is a tran- scriptional factor responsible for the up-regulation of PlGF by NE in LE ...
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HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0
... HSV- 1-infected PCCs was collected and filtered and supple- mented with nanomolar concentrations of the FGF- receptor inhibitor PD173074 or DMSO only ...file 1: Figure S1). Strikingly, there was no dif- ...
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LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway
... Results: LL-37 treatment enhanced the proliferation and migration of human ASCs expressing formyl peptide receptor like-1. Microarray and real-time PCR data showed that EGR1 expression was rapidly and ...
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Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin 1beta
... and growth factors and their receptors were a major group of IL-1-modulated genes in chondrocytes (Table 2, panel ...inhibitor factor precursor (LIF) was substantially induced by IL-1β in SW1353 ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... A major advantage of small molecule inhibitor is its ability to inhibit both IGF-1R and insulin receptor. Such ability was demonstrated in several human tumor cell lines, where phosphorylated IGF-1R and its downstream ...
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Ovine placental lactogen and insulin like growth factor I : a study of their biological actions and potential to enhance animal production : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Animal Science at Massey University, Palmerston North, New Zealand
... little growth promoting effect in well-fed ...to 1 10% maintenance and were treated by 3x daily sc injection for either 8 or 1 2 weeks with recombinant human IGF-I ( 1 50 ug/kg LW/day) or ...
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Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy
... Abstract: Vascular normalization is a new concept of targeting angiogenesis to restore vessel structure and function and to increase blood perfusion and delivery of drugs. It has been confirmed that vascular ...
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Surviving ischemia: adaptive responses mediated by hypoxia inducible factor 1
... angiogenic response potential as manifested in an animal model, discuss molecular mechanisms underlying the limited angiogenic response in humans, and consider strategies to cir- cumvent these ...
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Absence of Poly(ADP-ribose) Polymerase-1 Alters Nuclear Factor-κB Activation and Gene Expression of Apoptosis Regulators after Reperfusion Injury
... very early event in myocardial injury. Cas- pase-3, but not caspase-1, has been shown to cleave the 112 kDa nuclear protein PARP into an 85 kDa apoptotic fragment (30,31), and this cleavage by caspase-3 has ...
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Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema
... that S100A4 may be involved in early vascular remodeling even in non-hypoxic, mild COPD-stages. But what is the mechanism behind the up-regulation of S100A4 in ab- sence of hypoxia? We could show that human S100A4 ...
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Adult growth hormone deficiency treatment with a combination of growth hormone and insulin like growth factor 1 resulting in elevated sustainable insulin like growth factor 1 and insulin like growth factor binding protein 3 plasma levels: a case report
... However, the use of GH replacement therapy has not always resulted in consistent increases of IGF-1 in AGHD patients. The mechanism of this inconsistency has been studied by De Gennaro et al. [3]. In a series of ...
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Sensing Adenovirus Infection: Activation of Interferon Regulatory Factor 3 in RAW 264.7 Cells
... IRF3 following rAdV infection; rather, levels of activated IRF3 were often elevated compared to shscrambled-infected cells. In contrast, knockdown of Aim2 and DDX41 resulted in dimin- FIG 8 Summary model of rAdV-sensing ...
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Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... The TGF-b superfamily consists of more than 40 members, which are similar in structure and function. TGF-b is secreted as a homodimer, and its ligands include TGF-b, activin, and bone morphogenetic protein (BMP), which ...
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