ECM degradation
Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells
... Methods: Human hepatocellular carcinoma cell line SMMC7721 and HepG2 were cultured in DMEM supplemented with 10% FBS, RT-PCR and western blot were used to detect the endogenous expression of GRP78, MMP-2, MMP-9 and ...
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Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model
... Figure 4. BBR’s effects on apoptosis and ECM degradation are reversed by 3-MA. (A-B) Protein expression of Bax, Bcl-2, Cytochrome C and Cleaved-caspase3 of NP cells which pretreated with 3-MA and followed ...
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Regulation of ECM degradation and axon guidance by growth cone invadosomes
... of ECM degradation A defining characteristic of invadosomes is their ability to degrade the local matrix, allowing cells to remodel and penetrate tissues (Linder et ...showed degradation at molecular ...
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Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo
... expressing ECM-degrading ...in ECM degradation at the leading edge of invasive cancer cells ...coordinate ECM degradation, thereby facilitating cell migration and invasion ...matrix ...
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Long non coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β catenin pathway
... Fig. 4 Knockdown of HOTAIR attenuates IL-1 β -induced human NP cell senescence, apoptosis, and ECM degradation. a RT-qPCR analysis of HOTAIR expression in NP cells. b RT-qPCR analysis of MMP-3, MMP-9, ...
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Antifibrotic Effects of Limbal Mesenchymal Stem Cells-Conditioned Media (LMSCs-CM) on Human Tenon’s Fibroblasts (HTFs) in Glaucomatous Eyes: Comparison with Mitomycin C
... collagen degradation in ...less ECM was produced by fibroblasts after exposure to MSC-conditioned medium, and transplantation of rat MSCs into infarcted rat myocardium attenuated the fibrotic response as ...
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CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling
... Here, we demonstrate that by regulating invadopodia formation, assembly and extracellular matrix (ECM) degradation, CIP4 controls cell migration and invasion in response to EGFR signaling. We further ...
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IL 1β receptor antagonist (IL 1Ra) combined with autophagy inducer (TAT Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes
... attenuate ECM degradation in human OA chondrocytes In human OA chondrocytes (Table 1), IL-1β reduced Col II, Aggrecan, Beclin1 protein levels, and the ratio of LC3B-II/I, while addition of IL-1Ra reversed ...
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LncRNA MALAT1/MiR 145 Adjusts IL 1β Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis
... matrix degradation and the loss of chondrocyte ...MALAT1-mediated ECM degradation and anti-proliferation by inhibiting ADAMTS5 in IL-1β-induced ...
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Macrophage phenotype in response to ECM bioscaffolds
... There was a clear difference between the response of BMDM and THP-1 macrophages to both canonical stimuli such as IFNy + LPS or IL-4 as well as to SIS-ECM and UBM-ECM degradation products. Gene ...
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HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets
... and ECM degradation abilities were not affected by HIF-1α silencing, these cells were less capable of establishing metastasis once injected into the ...
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Fibrotic extracellular matrix activates a profibrotic positive feedback loop
... We found it intriguing that so few genes were linked to cell origin. To determine whether such genes are truly differentially expressed, we compared our results to cell origin–linked genes from one of our prior studies ...
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Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways
... Materials and methods: Two mouse liver fibrosis models were established by intraperitoneal injection of carbon tetrachloride (CCl 4 ) for 8 weeks and bile duct ligation for 14 days. Salidroside was injected ...
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ECM remodeling in hypertensive heart disease
... the ECM include changes in the number and function of other resident cells, myocardial apoptosis, and changes in calcium handling associated with impaired ...in ECM in the heart that characterize HHD. The ...
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Differentiated osteoblasts derived decellularized extracellular matrix to promote osteogenic differentiation
... The CD-ECM contains specific molecules secreted by the cells as well as growth serum proteins during prolif- eration. The composition of CD-ECM molecules can change according to the differentiation medium ...
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Functional Electrospun Nanofibers for Biocatalysis and Tissue Engineering.
... engineering field as a satisfactory scaffold structure based because of their high surface area to volume ratio, pore interconnectivity and 3D fiber network structure similar to natural extracellular matrix (ECM) ...
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... Matrix: ECM was present in interactions in the morphogenesis and differentiation of developing tooth including budding of oral epithelium and condensation of neural crest cells around the ...that ECM may ...
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Faster cofactorization with ECM using mixed representations
... In [13] Edwards introduced a new normal form for elliptic curves which, among other advantages, benefit from fast elliptic operations. These curves have been generalized by Bernstein et al. [2]. A new coordinate system ...
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Optimization of MRR on ECM Using Taguchi Method
... Electro-chemical Machining (ECM) is one of the most potential unconventional machining processes. This process generally belongs to a category called as electro-chemical category. ECM process may be ...
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Decellularized bone extracellular matrix and human dental pulp stem cells as a construct for bone regeneration
... More recently, we showed that bECM hydrogel scaffolds were also able to stimulate odontogenic differentiation of human dental pulp stem cells (DPSCs) by upregulating the expression levels of the ...
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