Effector and memory cells
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
... T cells that have been expanded ex vivo is being actively pursued to treat infections and malignancy in ...both effector memory and central memory cells, and these differ in phenotype, ...
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Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation
... of effector mem- ory-derived virus pre-therapy indicates that in the case of dual HIV-1 infection one strain preferentially infects a specific CD4 + lymphocyte ...of effector memory cells by ...
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Assessment of metabolic and mitochondrial dynamics in CD4+ and CD8+ T cells in virologically suppressed HIV-positive individuals on combination antiretroviral therapy
... that effector T cells are generally more glycolytic [12,30,31] while memory and naïve T cells rely on oxidative phosphorylation and fatty acid metabolism ...that memory T cells ...
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NKG2D signaling certifies effector CD8 T cells for memory formation
... NK cells were unable to respond to IL-15 stimulation despite expressing similar levels of IL-15 receptors as wildtype NK ...NK cells. While DAP10 was required for IL-15-induced signaling in NK cells, ...
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Gamma Interferon Regulates Contraction of the Influenza Virus-Specific CD8 T Cell Response and Limits the Size of the Memory Population
... T cells are generally formed against the conserved internal proteins of the virus (2, 3), newer generations of vaccines aim to generate better CD8 T cell memory responses against ...control memory ...
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Atypical Human Effector/Memory CD4(+) T Cells With a Naive-Like Phenotype
... naive-like effector/memory cells can be induced by vaccination, and whether they are associated with long-term memory responses and protection ...with effector functions may also have ...
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Memory AND effector cells in children with bacterial infections of the gastrointestinal and respiratory tracts
... T cells (CD3+, CD4+ and CD8+) in patients with bacterial infections were ...The memory T cell population is heterogeneous and consists of multiple subsets exhibiting different characteristics, including ...
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Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses
... controllers, memory cells have been identified as critical determinants of cytotoxicity (35), and in studies using peptide-based cultured IFN-␥ ELISpot, expandable memory cells have been ...
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Signatures of immune reprogramming in anti-CD52 therapy of MS: markers for risk stratification and treatment response
... T cells: naïve T cells, T effector cells, T memory cells, regulatory T cells; T-helper subsets: Th1, Th2, Th17), B-cell subsets (recent bone marrow emigrants, mature ...
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Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
... T cells proliferate enormously and develop into effector T cells capable of immediate effector functions, such as cyto- toxicity and IFN- γ production (1, ...activated effector T ...
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Generation mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis
... + effector B cells shown in our study and FcRL4 + RANKL + effector B cells ...B cells of patients with RA; however, it was not appreciably ob- served in PB B cells of both HC and ...
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Relative Importance of Rotavirus-Specific Effector and Memory B Cells in Protection against Challenge
... virus-specific effector and memory B cells in protection against challenge, virus-specific IgA, IgG, and IgM responses were measured both before and immedi- ately after ...
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A disease associated PTPN22 variant promotes systemic autoimmunity in murine models
... B cells from healthy individuals with the variant allele exhibit deficits in AR-induced calcium mobilization (8, 9, ...B cells from RA subjects carrying the risk allele exhibit augmented MAPK signaling in ...
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A Novel Single Cell FISH Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV 1 Transcription in HIV Infected Patients
... of cells expressing HIV RNA; however, we were not able to detect a significant production of viral ...of cells expressing HIV and viral proteins were successfully ...on cells with high expression of ...
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Exhaustion of tumor specific CD8+ T cells in metastases from melanoma patients
... T cells. The second experiment included tumor- specific T cells from blood and metastasis, and CMV-specific T cells from ...B cells, monocytes, and dendritic cells, and found that ...
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T cells in ANCA associated vasculitis: what can we learn from lesional versus circulating T cells?
... T cells are also involved in disease ...T cells in the immune response in ...T cells are present in granulomas, vasculitic lesions, and ...T cells usually show pro-infl ammatory properties and ...
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Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell mediated HIV 1 transmission
... Th2 cells respectively. To gen- erate fully polarized Th cells, the cells were restimulated with PHA (10 μ g/ml; Difco, Detroit, MI, USA) and 3000 rad-irradiated feeder cells (PBMC of two ...
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Lack of concordance between residual viremia and viral variants driving de novo infection of CD4+ T cells on ART
... discordance between residual viremia and recent infec- tion events might be due to anatomical compartmen- talization of those two “active” reservoirs, and supports the potential existence of anatomical reservoirs in ...
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Attenuation of Peripheral Regulatory T Cell Suppression of Skin Homing CD8+T Cells in Atopic Dermatitis
... action exist for these cytokines to promote Tregs suppres- sive functions. First, these cytokines can directly inhibit ac- tivation and/or survival of Teff cells themselves, thereby dampening autoreactive Teff ...
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Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
... thawed, cells were transferred from the cryovial to a 30-ml ...the cells while the tube was gently ...tube. Cells were centrifuged at 200 g for 8 ...and cells were counted. Cells were ...
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