Efflux pump inhibitors
EFFLUX PUMP INHIBITORS: ENHANCE THERAPY AND CAUTERIZE TUBERCULOSIS
... of efflux pump inhibitors, in conjugation with the existing of new drugs, to help build the potency of current against tuberculosis ...utilizing efflux pump inhibitors as aides ...
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Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of <em>Staphylococcus aureus</em>
... NorA efflux pump which is capable of extruding numerous structurally diverse ...NorA efflux pump is considered as a potential drug target for the development of efflux pump ...
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Development of an accumulation assay and evaluation of the effects of efflux pump inhibitors on the retention of chlorhexidine digluconate in Pseudomonas aeruginosa and Staphylococcus aureus
... standard efflux pump inhibitors, either CCCP or reserpine was studied using the protocol developed based on the procedure out- lined by Mortimer and Piddock ...
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Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review
... active efflux pumps. To date, 11 different efflux pumps of the RND family in ...the efflux of antibiotics/anti-microbial production have been ...Recently, Efflux Pump Inhibitors ...
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Synthesis and Characterization of Piperine Analogs as Potent Staphylococcus aureus NorA Efflux Pump Inhibitors
... The prepared analogs 5, 6 and 7a-e were bio evaluated for their potentiation of the anti infective activity of ciprofloxacin in Staphylococcus aureus 1199B over expressing the targeted Nor A efflux pump ...
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Conessine as a novel inhibitor of multidrug efflux pump systems in Pseudomonas aeruginosa
... potent efflux pump inhibitors including phenylalanyl arginyl β -naphthylamide (PA β N), carbonyl cyanide m-chloro- phenylhydrazone (CCCP), quinoline derivatives, and 1-(1-Naphthylmethyl)-piperazine ...
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Determination of imipenem efflux-mediated resistance in Acinetobacter spp., using an efflux pump inhibitor
... transmitters. Efflux pumps usually act synergistically with decreasing the per- meability of the outer membrane, which leads to removing antibacterial agents ...(8). Efflux pumps are divided into 5 families ...
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Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics
... through efflux pumps. Efflux pumps acquire a wide range of substrate specificity and also the tremendous efficacy for drug molecule extrusion outside bacterial ...of efflux pumps may rejuvenate the ...
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An Update on Plant-Derived Compounds as Potential Inhibitors of the Bacterial Efflux Pumps: With Reference to Staphylococcus aureus and Escherichia coli
... bacterial efflux pumps are responsible for imparting resistance to many ...on Efflux Pump Inhibitors (EPI) from plant resources urges immediate ...many efflux pump ...
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Abstract
... Tet(K) efflux pump, which exchanges the antibiotic for a proton in the antiport mode of translocation ...when efflux is active. Since reserpine and CCCP are known to be efflux pump ...
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Effect of proton pump inhibitors on male fertility
... Proton pump inhibitors are commonly used drugs for treating acid peptic disorders like peptic ulcer, gastro oesophageal reflux disorders, NSAID induced mucosal injury, Zollinger Ellison syndrome and ...
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Azithromycin Resistance through Interspecific Acquisition of an Epistasis Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae
... functional pump complex ...the pump (residues 608 to 619), or the sites involved in forming the proton relay network of the pump ...the pump (Table ...
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Investigation of Cuscfba Pump Among Uropathogenic Escherichia Coli (UPEC) Isolated from Women with Cystitis, Iraq.
... CusCFBA efflux complexes in the resistance-nodulation-cell division (RND) family to expel diverse toxic compounds from the ...multidrug efflux pump from ...the efflux of heavy metal ions from ...
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Management of laryngopharyngeal reflux with proton pump inhibitors
... Abstract: There is a lack of consistent guidelines and consensus for the diagnosis of laryngopharyngeal refl ux (LPR). A therapeutic trial with a proton pump inhibitor (PPI) has been suggested to identify patients ...
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Interaction between Warfarin and Proton Pump Inhibitors
... Background: Interaction between proton pump inhibitors (PPI) and warfarin is controversial. Previous clinical studies have only a short follow-up period. Methods and Results: All patients (n = 716) for whom ...
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Long-term effects of proton pump inhibitors
... proton pump inhibitors (PPIs) block acid secretion from all three pathways simultaneously, they are considered the most potent medications available to reduce gastric acid ...
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Bupropion, methylphenidate, and 3,4 methylenedioxypyrovalerone antagonize methamphetamine induced efflux of dopamine according to their potencies as dopamine uptake inhibitors: implications for the treatment of methamphetamine dependence
... uptake inhibitors bupropion and methylphenidate may therefore prevent methamphetamine from interacting with the DAT to release DA, and such an effect would antagonize effects of ...uptake inhibitors have ...
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Thiolation of Polymers; A re-oriented approach towards targeted drug delivery.
... Targeted drug delivery remains a challenge for the pharmaceutical scientists due to less solubility of API and less compatibility and contact time of excipients with mucous membrane. Modification in the composition of ...
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Cryo Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump
... D407, allowing these two residues to form a hydrogen bond (Fig. 6B). This conforma- tional state is also stabilized by the contribution of D408, which interacts with K973 to form another hydrogen bond. Presumably, an ...
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Phytochemical Composition and Anti-Efflux Pump Activity of Hydroalcoholic, Aqueous, and Hexane Extracts of Artemisia tournefortiana in Ciprofloxacin-Resistant Strains of Salmonella enterica Serotype Enteritidis
... To extract RNA, ciprofloxacin-resistant and in- termediate strains were cultured in Nutrient broth for 24 h at 37 °C with sub-MIC concentra- tions of hydroalcoholic extract. Subsequently, RNA extraction was performed ...
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