EGF-R
Targeted expression of a dominant negative EGF R in the kidney reduces tubulo interstitial lesions after renal injury
... truncated EGF-R is expressed exclusive- ly in proximal tubular cells, these results provide evi- dence for a cross-talk between tubular and interstitial cells in injured kidneys and demonstrate that tubular ...
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Evidence for intracellular down-regulation of the epidermal growth factor (EGF) receptor during adenovirus infection by an EGF-independent mechanism.
... Although there was a clear reduction in EGF-R PTK activity following infection with wild-type virus versus a 13.7 kDa/ 11.3 kDa deletion mutant by 24 h p.i., the effect was more pronounc[r] ...
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EGF receptor and its ligands, EGF and TGF alpha, in developing and neoplastic human odontogenic tissues
... Int I De\' BioI 37 387 396 (1993) 387 Original Arlirl,' EGF receptor and its ligands, EGF and TGF a, in developing and neoplastic human odontogenic tissues KRISTIINA HEIKINHEIMO"", RAIMO VOUTILAINEN',[.] ...
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Ionic signalling by growth factor receptors
... Comparison of the biological effects, of EGF and anti-EGF receptor monoclonal antibodies on human A431 cells and fibroblasts Precipitation of EGF receptor EGF binding competition Stimula[r] ...
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Production of heparin binding epidermal growth factor like growth factor in the early phase of regeneration after acute renal injury Isolation and localization of bioactive molecules
... The EGF receptor of A431 cells was also ty- rosine phosphorylated by this eluate ...HB- EGF indicated that the eluate peak contained immunoreac- tive proteins of 22 and 29 kD mol wt, consistent with the re- ...
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Human squamous cell lung cancers express increased epidermal growth factor receptors
... of EGF receptor are detected in biopsy specimens of human squamous cell carcinomas of the lung with a murine monoclonal antibody, EGF-R1, which binds specifically to the ...of EGF receptor. The ...
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Hennes, Nadine Regina (2008): Untersuchungen zur Expression und Lokalisation des epidermalen Wachstumsfaktors (EGF) und seines Rezeptors (EGFR) im Intestinaltrakt des Schweines. Dissertation, LMU München: Tierärztliche Fakultät
... von EGF im GIT der Nager und des Menschen in den Speicheldrüsen erfolgt (Gresik & Barka, 1978, Murphy, ...der EGF bei diesen Spezies im Bereich des GIT noch in den Brunner-Drüsen (Mensch, Heitz et ...
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“Effect of Sildenafil on Pancreatic Epidermal Growth Factor Expression and β-Cell Function” by Ibrahim Hassan Nashmee, Dr. Mustafa Ghazi Al-Abbassi, Dr. Mustafa Mohammed Al-Obeidy, Iraq.
... and EGF receptor signaling stimulates proliferation and morphogenesis of fetal pancreatic ...lacking EGF receptors 6 . EGF deficiency contributes to the pathology of many disease ...of EGF, ...
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When EGF is offside, magnesium is wasted
... receptor on the basolateral membrane of DCT cells and activation of the Mg 2+ channel TRPM6 (transient receptor potential cation channel, subfamily M, member 6) in the apical membrane. These authors show that a point ...
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Safety Evaluation of GP-EGF Lyophilised Powder
... Koteshwar R, Shenoy AM, Thimmaiah N, et ...against EGF-receptor with chemo- radiation therapy or with radiation therapy in patients with advanced (stage III–IVa), inoperable head and neck ...
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Epidermal growth factor receptor number decreases during rat liver regeneration
... The potential role of epidermal growth factor (EGF) in the regulation of rat liver regeneration was examined by assessing the binding of 125I-EGF to hepatic membranes isolated at various times after partial ...
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EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells
... We first sought to determine which EGF receptors are expressed in monocytes. For this purpose, RNA was iso- lated from monocyte cultures and processed for qPCR using primers for EGFR (also termed ERBB1), ERBB2, ...
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Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha
... both EGF and transforming growth factor-alpha ...the EGF receptor, EGF, and TGF-alpha are found in both pancreatic acini and ducts in the normal human pancreas, and that all three proteins are ...
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Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patients
... On the other hand, the proto-oncogene c-erb-B, referred to as epidermal growth factor (EGF) receptor (EGFR), is a well-known tyrosine kinase growth factor receptor. Four members of the EGFR family have been ...
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Influence of human HB-EGF secreted form on cells with different EGFR and ErbB4 quantity
... activation of p38 and erK 1/2 (p42/44) maPK kinases in different cell lines mediated by rsHB- eGF. The MAP kinase pathway is the major cas- cade involved in the regulation of cell prolifera- tion, migration and ...
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The Beneficial Role of Vitamin D in Interstitial Cystitis
... Urinary EGF levels were significantly elevated in IC patients compared with asymptomatic controls (Keay et ...of EGF than controls (Keay et ...and EGF- induced nuclear translocation of activated ...
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Localization of heparin binding EGF like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques
... Heparin-binding EGF-like growth factor (HB-EGF) is a potent chemoattractant and mitogen for smooth muscle cells (SMC) in ...HB- EGF was dramatically decreased in young and middle-aged ...Furthermore, ...
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Differential phosphoprofiles of EGF and EGFR kinase inhibitor-treated human tumor cells and mouse xenografts
... The wide range of cellular processes that are known to involve protein phosphorylation as central elements of their regulation suggest that a clearer picture of these events would be valuable in understanding cellular ...
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Extracellular matrix modulates epidermal growth factor receptor activation in rat glomerular epithelial cells
... prolonged EGF-R tyrosine autophosphorylation (which reflects receptor kinase activation) was induced by EGF in GEC adherent to collagen, but EGF did not stimulate EGF-R ...
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Modulation of Trophoblast Cell Death by Oxygen and EGF
... BSA DMEM:Ham F-12 (without phenol red) for 15 min and then washed three times with PBS. The PI3K inhibitor, LY294002, was incubated at the stated concentration for 30 min. EGF or appropri- ate vehicle was given as ...
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