EGFR protein
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
... whether EGFR protein overexpression or EGFR gene amplification could select patients who would benefit from anti EGFR ...between EGFR immunohistochemical expression and response to ...
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Overexpression of mutant EGFR protein indicates a better survival benefit from EGFR-TKI therapy in non-small cell lung cancer
... mutated EGFR was correlated with PFS when gefitinib administration ...mutated EGFR would be helpful for efficacy prediction of EGFR-TKIs in individuals with NSCLC carrying EGFR ...mutations. ...
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Original Article Significance of elevated ERK expression and its positive correlation with EGFR in Kazakh patients with esophageal squamous cell carcinoma
... contain ERK1 and ERK2. These two kinases are required for physiological processes, such as cell growth, differentiation, apoptosis, and tumorigenesis in various malignancies [31]. However, the MAPK signaling pathway, as ...
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<p>Epidermal growth factor receptor (<em>EGFR</em>) gene alteration and protein overexpression in Malaysian triple-negative breast cancer (TNBC) cohort</p>
... the EGFR signaling pathway. The major breakthrough in EGFR-tar- geted therapy against metastatic TNBC came from the European Society of Medical Oncology which reported a 20% response in patients with ...
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Adrenal cortical neoplasms: a study of clinicopathological features related to epidermal growth factor receptor gene status
... the EGFR gene copy number in conventional ACC and ...between EGFR copy number and the clinicopathological features of pa- tients with ...the EGFR gene copy ...demonstrated EGFR amplification, ...
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Effects of ethanolic extract of Annona squamosa L leaves on the expression of EGFR
... of EGFR protein using confocal immunofluorescence ...of EGFR protein as compared to the control (Figure ...of EGFR, but extract-treated cells showed intercellular ...of EGFR ...
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Original Article Relationship between EGFR gene copy number variation and EGFR mutations, protein expression, and clinicopathologic parameters in lung adenocarcinoma
... 21. EGFR mutations are frequently detected in cases with lepidic and papillary growth and are asso- ciated with thyroid transcription factor-1 (TTF-1) positivity ...study, EGFR muta- tions were ...
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Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3)
... functions. EGFR is known as a key RTK and leading therapeutic target in many cancers including gliomas ...the EGFR protein, as early as 1 day after Dox induction, with the effect persisting at least ...
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Co-targeting of EGFR by co-expressed miRNA-193a-3p/−5p in lung cancer
... the EGFR protein and mRNA ...the EGFR protein expression were sup- pressed by miRNA-193a-3p/−5p mimics ...increased EGFR protein expression in cancer cells ...contrast, ...
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Original Article TTF-1 and EGFR expression are related to EGFR mutation in lung adenocarcinoma
... of EGFR muta- tions. EGFR TKIs are shown to be superior to chemotherapy in first-line therapy of advanced NSCLC patients with EGFR ...Although EGFR mutations are strongly correlated to ...
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Molecular predictors of response to tyrosine kinase inhibitors in patients with Non-Small-Cell Lung Cancer
... of EGFR, this was found positive in 16% of the cases tested and no correlation with clinical outcome was ...of EGFR protein varies across several studies and as such, has been an inconsistent ...
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Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors
... specific EGFR kinase activating mutations (L858R, delE746-A750) respond well to tyrosine kinase inhibitors ...the EGFR kinase domain ...by EGFR mutants have been shown to be responsible for ...
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Evaluating the predictive value of biomarkers for efficacy outcomes in response to pertuzumab and trastuzumab based therapy: an exploratory analysis of the TRYPHAENA study
... (serum protein and mRNA), betacellulin (mRNA), IGF-1R (protein), PTEN (protein), transforming growth factor alpha (TGFα) (serum protein), epidermal growth factor (EGF) (serum protein), ...
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PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway
... After protein synthesis inhibitor CHX treat- ment for different time, EGFR expression was reduced immediately in PLEK2 knockdown cells compared to control cells ...of EGFR. Given that PLEK2 altered ...
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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer.
... EGFR mRNA ( left panel ) and EGFR protein levels ( right panel ) in HEK-293T. (e) Inhibition of[r] ...
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Butler_unc_0153D_17317.pdf
... includes protein and RNA expression data on genes used to define intrinsic subtype and genes involved in mechanistic pathways that may link smoking to breast cancer risk (Table ...and protein-specific cut ...
136
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
... Glioblastoma multiform (GBM), WHO grade IV, is the most common and aggressive glioma of all primary brain tumors, exhibiting a high rate of recurrence and poor prognosis due to the invasive nature of the tumor [1, 2]. ...
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Salinomycin co-treatment enhances tamoxifen cytotoxicity in luminal A breast tumor cells by facilitating lysosomal degradation of receptor tyrosine kinases
... Even though most ERα positive breast tumors initially respond to endocrine therapy, a majority relapses after several years and turns insensitive to tamoxifen treatment [28]. Drug resistance mechanisms can be ...
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Download Download PDF
... Inhibited EGFR/PI3K/Akt signaling pathway in miR-361-5p mimics-transfected MDA-MB-231 TNBC ...and protein expression was ...p-PI3K, EGFR, p-EGFR, Akt, p-Akt, and MMP-9 protein ...
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Distinct expression and prognostic value of members of the epidermal growth factor receptor family in ovarian cancer
... 5%) (Figure 4B). After cBioPortal, Kaplan–Meier plotter and log-rank test, the results indicated that there are no significant difference in OS and disease-free survival (DFS) in cases with or without alterations in one ...
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