EGFR signalling
The vav oncogene antagonises EGFR signalling and regulates adherens junction dynamics during Drosophila eye development
... the EGFR pathway are upregulated in vav mutant larval eye disc and pupal retina, indicating that Vav antagonises EGFR signalling during eye ...decreasing EGFR signalling in vav mutant ...
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Atonal and EGFR signalling orchestrate rok and Drak dependent adherens junction remodelling during ommatidia morphogenesis
... (EGFR) signalling pathway, which transcriptionally governs rok- and Drak - dependent AJ remodelling while also promoting ...Ato, EGFR-dependent transcription and AJ remodelling in a system in which ...
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Hypoxia induced reactive oxygen species mediate N cadherin and SERPINE1 expression, EGFR signalling and motility in MDA MB 468 breast cancer cells
... of EGFR, but did not have any effect on hypoxia- mediated induction of ...and EGFR activation, suggesting its possible involvement in these hypoxia-mediated ...and EGFR (associated with migratory ...
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Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis
... EGF/EGFR signalling module is involved in MVP-mediated GBM cell survival, migration and PI3K pathway ...of EGFR inhibition ...E. EGFR and MVP contents of plasma membrane-enriched (membrane), ...
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
... TGFb1 signalling, suppresses MATN2 expression, suppresses EGFR surface retention, and suppresses EGFR ...inhibits EGFR plasma membrane localization in tumours, and it suppresses tumour growth ...
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When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling
... many signalling processes at the cellular level, largely due to the development of sophisticated and high- throughput biochemical techniques in proteomics and other ...understand EGFR signalling and ...
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Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling
... tering of Erk from MAPK signalling. To explore this we used cell-based assays to assess how downstream signalling might be affected by the inhibitory presence of indomethacin. A panel of cell lines which ...
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Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid triggered EGF pathway
... of EGFR signalling, we analyzed their sequences searching for evolutionarily conserved motifs and transcription factor binding sites, with special focus on the ETS sites to which EGFR effectors ...in ...
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Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling
... Notch signalling as another likely paracrine pathway since it has been reported [21] and we confirm here that Notch1 signalling activity increases fol- lowing exposure to oestrogen (Figure ...suggesting ...
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Multiple RTK pathways downregulate Groucho mediated repression in Drosophila embryogenesis
... to EGFR signalling, and that such regulation is essential for the correct patterning of the adult wing (Hasson et ...the EGFR, FGFR and Torso receptors – elicit phosphorylation of Gro in various ...
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Schäfer, Beatrix (2004): Transactivation of the EGFR Signal in Human Cancer Cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... mitogenic signalling pathway stimulation with LPA and angiotensin II results in accumulation of the cell cycle regulator cyclin D1 in the kidney cancer cell line ACHN which is dependent on the EGFR and a ...
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Original Article TTF-1 and EGFR expression are related to EGFR mutation in lung adenocarcinoma
... body with a nonrelated mouse immunoglobulin at a comparable dilution or using normal serum alone. Positive and negative controls were used as appropriate. Immunoreactivity was rendered semiquantitatively on a scale from ...
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The Role of GABA Signalling in Lung Macrophage Immune Response
... GABA signalling within this specific cell type, it is likely the case that the cells would function differently in vivo when surrounded by neighboring immune ...
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Comparative bioinformatic analysis suggests that specific dauer like signalling pathway components regulate Toxocara canis development and migration in the mammalian host
... Distinctiveness in signalling between T. canis and A. suum might relate to differences in biology and/or devel- opmental regulation. Although the dauer-like signalling pathways of T. canis and A. suum were ...
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Glatt_unc_0153D_16443.pdf
... EGFR binding of 64 Cu-labeled panitumumab Fab’ was assessed in a panel of EGFR expressing cells lines, including high EGFR-expressing A431 cells, moderate EGFR-expressing M[r] ...
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An In Silico Comparative and Pathway Analysis of Targeted Genes of Diabetic Retinopathy: A Prognostic Approach towards Diabetic Retinopathy
... miRNA – target pathway interactions were performed for miRNA 21 and their targeted gene IL1B by using mirwalk database, their interaction was found in apoptosis and MAPK signalling pathway which are previously ...
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Advances in mass spectrometry based strategies to study receptor tyrosine kinases.
... RTK signalling in large-scale panels of cell lines and ...RTK signalling profiles on a patient-by-patient basis is required to contribute to ongoing efforts to develop personalized medi- cine in the form of ...
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Prediction of mortality and functional decline by changes in eGFR in the very elderly: the Leiden 85-plus study
... low eGFR and more rapid cognitive decline [21], frailty [22] and ADL disability ...the eGFR, the decrease in the eGFR or a combination of the two and a change in the MMSE, GDS or ADL ...baseline ...
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Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer
... Of the 25 patients who had uncommon EGFR E709X mutation, 7 did not receive TKIs in their treatment course (Table 5). One patient received treatment in another hospital after a diagnosis of cancer (case 19). Two ...
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Disentangling juxtacrine from paracrine signalling in dynamic tissue
... Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator found underneath the brain. In mammals it is crucial for milk production and reproductive function. Production of such an ...
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