eIF4E binding protein-1
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer
... eIF4E binding protein 1 (4E-BP1), is critical for cap-dependent and cap-independent translation. This study is the first to demonstrate that 4E-BP1 expression correlates with colorectal cancer ...
13
Effects of Simian Virus 40 Large and Small Tumor Antigens on Mammalian Target of Rapamycin Signaling: Small Tumor Antigen Mediates Hypophosphorylation of eIF4E-Binding Protein 1 Late in Infection
... SV40 infection of primary AGMK cells shows additional effects on mTOR effectors. CV-1 cells are an established and immortalized cell line which cannot be significantly growth arrested by serum starvation. ...
8
Mutational Analysis of Plant Cap-Binding Protein eIF4E Reveals Key Amino Acids Involved in Biochemical Functions and Potyvirus Infection
... of eIF4E in the potyvirus cycle have been proposed based on its known biological and biochemical features (18, ...of eIF4E is to bind the cap at the 5 ⬘ mRNA end, promoting its recruitment by the ribo- ...
12
Sapovirus Translation Requires an Interaction between VPg and the Cap Binding Protein eIF4E
... to eIF4E and therefore can be used to enrich eIF4F-interacting ...The eIF4E-containing complex iso- lated from infected cells also contained PSaV VPg as both precur- sor and fully processed forms ...the ...
9
Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... factor eIF4E and related homologues that function as translation regulators are located mainly in the cytoplasm, although they can be detected at low levels in the nucleus ...The eIF4E homologues are ...
11
Regulation of signalling circuitry downstream of mTORC1(mammalian target of Rapamycin)
... of eIF4E regulation is through its interaction with a family of inhibitory binding ...with eIF4E, and which share 56% overall identity at the amino acid ...(for eIF4E-binding proteins ...
17
A translational rheostat for RFLAT 1 regulates RANTES expression in T lymphocytes
... of eIF4E on RFLAT-1 ...The eIF4E overexpression was induced by removal of tetracycline (37), and RFLAT-1 expression was measured 24 hours ...of eIF4E resulted in an approximately ...
9
Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1
... host protein synthesis, viral protein synthesis is not affected by activation of 4E-BP1, since viral mRNAs are translated at high rates in infected cells despite the activation of ...of protein ...
11
A link between protein translation and body weight
... mTORC1 binding to eIF3 and phosphory- lation of S6K1 at Thr389 by eIF3-associ- ated mTORC1 (Figure ...to eIF4E in a mutually exclusive manner, 4E-BPs may be unable to associate with eIF3 and be ...
5
Activity of the Hepatitis A Virus IRES Requires Association between the Cap-Binding Translation Initiation Factor (eIF4E) and eIF4G
... NS1 protein, rather than the slightly truncated form linked to the HAV and HRV IRESs, and because the NS coding sequences are joined to the authentic PV initiation codon via a short ...
10
Downregulation of selenium binding protein 1 is associated with poor prognosis in lung squamous cell carcinoma
... Selenium is an essential trace element for a lot of bio- logic processes and possesses anti-carcinogenic proper- ties. Forty years ago, supplemental dietary selenium was found to play an important role in decreasing ...
8
Human erythrocyte protein 4 1 is a phosphatidylserine binding protein
... with protein 4.1 restored PS liposome binding to control ...purified protein 4.1 to PS liposomes resulted in saturable binding with the extent of binding being proportional to the ...
7
TPO/Mpl Studies in Agnogenic Myeloid Metaplasia
... the protein either when the reaction was per- formed in the presence of microsomal membranes capable of post-translational modification in ...Mpl protein was ...over-expressed protein, the system for ...
10
Expression of 4E-BP1 and phospho-4E-BP1 correlates with the prognosis of patients with clear cell renal carcinoma
... (ab33766, 1:100 dilution, monoclonal; Abcam, Cambridge, MA, USA) or anti-eIF4E-BP1 (ab32024, 1:100 dilution, monoclonal; Abcam) antibody or anti-vascular endothelial growth factor C (VEGFC; ab83905, ...
11
Blastomyces Virulence Adhesin 1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase
... high-frequency binding of BAD-1 to heparin would be initiated by the Cardin-Weintraub site located at the N-terminal end of the protein ...repeat binding to heparin (Fig. 1B). Enhanced ...
12
Original Article Integrin β1 mediates 5-fluorouracil chemoresistance under translational control of eIF4E in colorectal cancer
... by binding to the mRNA cap, can regulate specific protein synthesis, contributing to malignancy in human ...between eIF4E and Integrin β1, along with their clinical significance was investigated in ...
14
Purification and Characterization of Human Adrenomedullin Binding Protein-1
... loss, especially for use in combat casu- alty care at the far-forward battlefield setting. Future areas of investigation should be directed toward completing further preclinical studies such as dose response, hemorrhage ...
8
Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK Binding Kinase 1 Mediated Signaling
... Cells, viruses, and antibodies. HEK293T, HFF, L929, and Vero cell lines were obtained from the American Type Culture Collection (Manassas, VA) and cultured in Dulbecco’s modified Eagle medium (DMEM) (Gibco-BRL) ...
10
The Leishmania PABP1–eIF4E4 interface : a novel 5′–3′ interaction architecture for trans spliced mRNAs
... cap-binding protein eIF4E and the poly(A) binding protein PABP ...of eIF4E and PABP with eIF4G pro- motes synergistic activation of translation initiation by the 5 and 3 ends has ...
12
Bradykinin activated membrane associated phospholipase C in Madin Darby canine kidney cells
... nucleotide-binding protein in receptor-mediated activation of PLC, we evaluated the role of guanine nucleotide proteins in receptor-mediated (bradykinin-stimulated) activation of PLC in MDCK ...cell ...
8