embryonic stem cells
Trophoblast Differentiation of Human Embryonic Stem Cells.
... trophoblast cells from human embryonic stem cells (hESCs) in cell culture is desirable since the availability of trophoblast tissues from very early gestation placentas is scarce, and in ...
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Comparative study of mouse and human feeder cells for human embryonic stem cells
... feeder cells are superior in the production of activin A, but do not secrete any measurable ...feeder cells for the support of hESC undifferentiated ...feeder cells was the only difference that was ...
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Porcine induced pluripotent stem cells analogous to naïve and primed embryonic stem cells of the mouse
... naïve embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig blastocysts, despite over 25 years of ...pluripotent stem cells (iPSC) from swine ...
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Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells
... of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) to generate a broad range of differentiated progeny in culture provides a powerful model system for studying ...
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SETDB1 in Early Embryos and Embryonic Stem Cells
... SETDB1 (SET domain, bifurcated 1), also known as ESET/ KMT1E, is a histone H3 lysine 9 (H3K9)-specific methyltransferase that is involved in the transcriptional silencing of euchromatic genes. Since it was identified via ...
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Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells
... of cells within a tumour, termed cancer stem cells (CSCs), have an enhanced capacity for tumour formation in multiple cancers and may be responsible for recurrence of the disease after treatment, ...
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Mapping molecular pathways for embryonic Sertoli cells derivation based on differentiation model of mouse embryonic stem cells
... Sertoli cells are as follows: the cells have a great variety in genital ridges and coelomic epithelium, the relevant factors have complicated interaction, the target genes are hard to manipulate in vivo ...
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Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells
... Sertoli cells are of great value in co-culture technique to provide immunosuppression for tissue transplant [10]; to improve the survival and proliferation of neurons [11, 12], mesenchymal stem cells ...
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Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease
... pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) and their in vitro differentiation models hold great promise for ...
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Codon usage optimization in pluripotent embryonic stem cells
... during stem cell differentiation raises the question of how they are ...potent embryonic stem cells is hampered by the fact that ADAT2/3 is essential for cell survival ...
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Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells
... severe embryonic defects and ...In embryonic stem cells, Tcf7l1 negatively modulates the expression of pluripotent genes, and prepares the epiblast for transition to lineage specification ...
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Generation of thalamic neurons from mouse embryonic stem cells
... To reveal the molecular mechanisms and the minimum patterning signals necessary for thalamic development, we used an in vitro differentiation culture of embryonic stem cells (ESCs) (Muguruma and ...
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Enrichment of therapeutic hematopoietic stem cell populations from embryonic stem cells
... at embryonic day ...mesoderm cells in the posterior primitive streak (a transient embryonic structure central to gastrulation [51]) demonstrate hemangioblast commitment through upregulation of a gene ...
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In vitro myelin formation using embryonic stem cells
... primary cells and in postmortem tissues or in vivo with animal models (Chen et ...of cells and animals available and by variability among individual animals, making large-scale experiments ...contrast, ...
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Specification of chondrocytes and cartilage tissues from embryonic stem cells
... mesenchymal stem cells (MSCs) are able to differentiate to chondrocytes in vitro; however, it is unclear whether they are able to give rise to ACs as the cartilage-like tissue generated from them undergoes ...
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Visualizing centrosome movement in mouse embryonic stem cells
... the cells over time in 3D structures, which we aim to do in the future with our gastruloids ...expressing cells, the best clone needs to be selected before experiments can ...
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Signaling pathways dictating pluripotency in embryonic stem cells
... The process of embryogenesis is initiated with the fertilization of a sperm with an ovum. The one-celled embryo divides to form the blastocyst (Fig. 1) comprising of inner cell mass (ICM) and trophectoderm. Within the ...
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Embryonic stem cells and transgenic mice in the study of hematopoiesis
... Our studies also illustrate how various approaches may be used to circumvent the earliest developmental block in embryonic lethal knockout mice to examine other gene functions. While the cre-loxP conditional ...
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Rediscovering pluripotency: from teratocarcinomas to embryonic stem cells
... the stem cell fate is a prerequisite in our pursuit to control the stem cell ...liver cells that could sustain self-renewal of mouse ES cells in the absence of feeders (Smith et ...ES ...
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LncRNAs and PRC2: Coupled Partners in Embryonic Stem Cells
... Xist levels are finely tuned by two nearby genes transcribed from the active X-chromosome, one of which is Jpx. The Jpx gene transcribes a lncRNA inducing Xist transcription and the antisense lncRNA Tsix, which enforces ...
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