Endochondral ossification
Interface between intramembranous and endochondral ossification in human foetuses
... thick: endochondral ossification occurred in a small area below the muscle attachment, as well as in a wide area above ...of endochondral ossifi- cation was continuous and intermingled with the area ...
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In vivo generation of bone via endochondral ossification by in vitro chondrogenic priming of adult human and rat mesenchymal stem cells
... of endochondral ossification as observed during development ...of endochondral ossification from embryonic stem cells and murine bone marrow cells supported the feasibility of such an approach ...
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A computational model to explore the role of angiogenic impairment on endochondral ossification during fracture healing
... and endochondral ossification, which is central to suc- cessful secondary fracture ...and endochondral ossification of chondrogeni- cally primed MSCs (Zhu et al, 2014; Sheehy et al, 2012; ...
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Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells
... of endochondral ossification in MSCs maintained in chondrogenic culture ...with endochondral ossification (BMP2, RUNX2, ALPL, OPN, and COL10A1) in a strain magnitude-dependent ...and ...
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SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
... The complete absence of Sox9 from hypertrophic chondrocytes suggested to us that Sox9 downregulation might be required to allow the onset of subsequent events of cartilage-bone transition such as induction of ...
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Incomplete Endochondral Ossification of the Otic Capsule, A Variation in Children: Evaluation of Its Prevalence and Extent in Children with and without Sensorineural Hearing Loss
... The small size of the control group is the main limitation of our study. Because SNHL is the prominent type of hearing loss in childhood and for this young age group CT of the temporal bone is mainly undertaken to ...
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An endochondral ossification approach to early stage bone repair: Use of tissue engineered hypertrophic cartilage constructs as primordial templates for weight bearing bone repair
... Mimicking endochondral ossification to engineer constructs offers a novel solution to overcoming the problems associated with poor vascularisation in bone ...
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Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription
... intramembranous ossification, or into chondrocytes to form the cartilage anlagen, which is eventually replaced by bone during endochondral ossification (Karsenty and Wagner, ...2002). ...
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Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
... during endochondral ossification is a hallmark of osteopetrosis, regardless of whether it is caused by impaired osteoclast formation or a defect in osteoclast function (Del Fattore et ...
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Engineering osteochondral constructs through spatial regulation of endochondral ossification
... via endochondral ossification ...the endochondral route may be superior to the traditional intramembranous process for bone regeneration is that hypertrophic chondrocytes are programmed to withstand ...
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Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx
... or endochondral component of an engineered phalanx construct, and a self-assembly strategy was used to engineer the overlapping articular cartilage layer using primary chondrocytes, as opposed to ...regulated ...
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BMP4 promotes chondrocyte proliferation and hypertrophy in the endochondral cranial base
... period, ossification centers form within the cartilage, and the segments separating these centers are referred to as ...period, endochondral ossification of the synchondroses contributes to the ...
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The roles of nitric oxide synthases (NOS) in endochondral bone formation
... called ossification. Ossification is an extremely complex, life-long process (Docherty, ...and endochondral ossification (Beier, 2005; Olsen et ...way. Endochondral ossification ...
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Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling
... in endochondral bone is that they are brought in by blood vessels that invade the ...ectopic ossification (Mori et ...the endochondral bones in ptc mutants is preceded by increased or premature ...
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Genetic analysis of Runx2 function during intramembranous ossification
... skeletal ossification processes during embryonic and postnatal ...intramembranous ossification, whereas other bones, such as the long bones and vertebrae ossify through endochondral ...the ...
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Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing
... Many signalling pathways including BMPs, FGFs, Wnts, IGFs and Hedgehog are recognised to orchestrate important roles in bone development, bone remodelling and fracture repair (Kronenberg 2003). For example, canonical Wnt ...
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Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification
... Mechanistically, fracture repair occurs through both intramembra- nous and endochondral ossification, the same biological processes that occur in bone development (1, 2). However, in contrast to bone ...
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Accelerated endochondral growth in adolescents with idiopathic scoliosis: a preliminary histomorphometric study
... abnormal endochondral ossification, but histological evidence is ...abnormal endochondral ossification in IS patients at early stage of puberty by histomorphometric analysis of their iliac ...
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Altered endochondral bone development in matrix metalloproteinase 13 deficient mice
... Staining of skeletons from Mmp13 –/– animals with Alizarin Red and Alcian Blue showed that all elements appeared normal and were equivalent in length compared with wild-type littermates (Fig. 2A). For microscopic ...
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Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels
... Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) have been shown to generate bone in vivo by executing an endochondral program. This may hinder the use of MSCs for articular cartilage ...
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