endoplasmic reticulum
The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum
... an endoplasmic reticulum (ER)- resident glycoprotein, UL148, which activates the unfolded protein response (UPR) but is fully dispensable for viral replication in cultured ...
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Translational control in the endoplasmic reticulum stress response
... 36. Calfon, M., et al. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 415:92–96. 37. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., and Mori, K. ...
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Endoplasmic reticulum stress and diabetic retinopathy
... Abstract: Endoplasmic reticulum (ER) stress is involved in the pathogenesis of several diseases including Alzheimer disease and Parkinson disease. Many recent studies have shown that ER stress is related to ...
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Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
... ER: Endoplasmic reticulum; ERS: Endoplasmic reticulum stress; FCM: Flow cytometry; FITC: Fluorescinisothiocyate; GRP78: Glucose-regulated protein 78; H/R: Hypoxia/reoxygenation; IMD: ...
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Endoplasmic reticulum mitochondria tethering in neurodegenerative diseases
... (encoding Parkin protein) is associated with juvenile onset autosomal recessive forms of PD. Parkin is ATF4-dependently upregulated during mitochondrial and ER stress, which regulates the functional interplay between ER ...
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The role of endoplasmic reticulum in human adipose tissue
... Adipose tissue plays a central role in the regulation of metabolic homeostasis. In obesity adipocytes are challenged by many insults: surplus energy, inflammation, insulin resistance and considerable endoplasmic ...
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Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
... Eukaryotic cells contain an elegant protein quality control system that is crucial in maintaining cellular homeostasis; however, dysfunction of this system results in endoplasmic reticulum (ER) stress and ...
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Endoplasmic reticulum stress in lung disease
... The crowded molecular environment of a cell ’ s interior poses a problem to protein synthesis. As a globular protein is made, its polypeptide chain must be folded into a specific final conformation. This involves stages ...
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Role of Endoplasmic Reticulum in Non-communicable Diseases
... Endoplasmic reticulum (ER) is a large membrane-bound organelle that provides high fidel- ity quality control in protein synthesis, maturation and ...
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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours
... The endoplasmic reticulum (ER) is an organelle with a major role in the synthesis of lipid and proteins and leads many cellular processes such as organogenesis, transcriptional activity, stress responses, ...
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Analysis of the Activities of the Inflammatory Cytokine Macrophage Migration Inhibitory Factor on Activation of Endoplasmic Reticulum Stress Responses
... Analysis of the Activities of the Inflammatory Cytokine Macrophage Migration Inhibitory Factor on Activation of Endoplasmic Reticulum Stress Responses Analysis of the Activities of the Inflammatory Cy[.] ...
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Endoplasmic reticulum-Golgi intermediate compartment protein 3 knockdown suppresses lung cancer through endoplasmic reticulum stress-induced autophagy
... Trafficking from the endoplasmic reticulum (ER) to the Golgi apparatus is elevated in cancer cells. Therefore, proteins of the ER-Golgi intermediate compartment (ERGIC) attract significant attention as ...
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Autophagy induction and CHOP under expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress
... To clearly understand these mechanisms of resistance, rheumatoid and osteoarthritis synovial fibroblasts RASF and OASF were exposed to endoplasmic reticulum ER stress such as thapsigargi[r] ...
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The Endoplasmic Reticulum Stress Sensor Inositol Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production
... ABSTRACT Bacterial infection can trigger cellular stress programs, such as the unfolded protein response (UPR), which occurs when misfolded proteins accumulate within the endoplasmic reticulum (ER). Here, ...
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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
... ABSTRACT The unfolded protein response (UPR) is a stress response pathway that is activated upon increased unfolded and/or misfolded proteins in the endoplasmic reticulum (ER), and enhanced ER stress ...
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The endoplasmic reticulum in plant immunity and cell death
... The endoplasmic reticulum (ER) is an organelle with impor- tant functions in eukaryotic cells. It connects to other cellular compartments [e.g., nucleus, Golgi apparatus, mitochondria, per- oxisomes, plasma ...
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Infectious Bronchitis Virus Generates Spherules from Zippered Endoplasmic Reticulum Membranes
... ABSTRACT Replication of positive-sense RNA viruses is associated with the rearrangement of cellular membranes. Previous work on the infection of tissue culture cell lines with the betacoronaviruses mouse hepatitis virus ...
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BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection
... BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are[.] ...
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Quantification of the plant endoplasmic reticulum
... the endoplasmic reticulum, and similar network-like struc- tures, whose data were acquired, digitised, and stored using a confocal ...the reticulum by its skele- ton, which is abstracted by a graph, ...
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Endoplasmic reticulum stress and apoptosis
... – endoplasmic reticulum; GADD 153 – growth arrest and DNA damage; GCN2 – general control of amino acid biosynthesis kinase; GRPs – glucose-regulated protein family; GSK3β – glycogen synthetase kinase-3β; ...
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