Endoplasmic reticulum stress (ERS)
Toxoplasma gondii dense granule protein 15 induces apoptosis in choriocarcinoma JEG 3 cells through endoplasmic reticulum stress
... of T. gondii Chinese 1 strains found in China [10–14]. Toxoplasma gondii can hijack host cell apoptotic ma- chinery and promote either an anti- or pro-apoptotic pro- gram depending on the parasite virulence and load, as ...
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Activation of endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance of human small cell lung cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway
... Endoplasmic reticulum (ER) is a major organelle having many cellular functions and is an essential site for maintaining homeostasis ...ER stress (ERS) [8]. With overwhelmed ERS, cells ...
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Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
... To determine whether IMD had a direct inhibitory effect on renal ERS, the ERS-inducer Tm (10 mg/ml) was in- cubated with the rat tubular epithelial NRK-52E cells line in vitro. We assessed cell apoptosis ...
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Endoplasmic reticulum stress in the pathogenesis of fibrotic disease
... Figure 1. Overview of ER stress–related signal- ing. Bip binds to accumulating misfolded pro- teins in the ER, leading to its dissociation from the three ER stress sensors, IRE1α, PERK, and ATF6. (i) ...
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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
... ER stress, gene ontology analysis for biological function of the upregulated genes showed enrichment in genes linked to ER stress and the UPR (Table ...
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Translational control in the endoplasmic reticulum stress response
... ER stress. In the context of the β cell, the induction of ER stress is a physiological con- sequence of the glucose-mediated increase in client protein ...
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Endoplasmic reticulum stress in lung disease
... PERK activates the third arm of the UPR. It is regulated in a manner similar to IRE1, but once activated PERK recruits and phosphorylates the translation initiation factor eIF2 α [38] (figure 1). Reports that PERK can ...
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Endoplasmic Reticulum Stress-Associated Chaperones, Bip/GRP78 and Calnexin are Overexpressed in Keratocystic Odontogenic Tumours
... ER stress and the resulting UPR may be associated with their ...ER stress markers BiP/ GRP78 and calnexin in the KCOTs but not in the PACs and the ...
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Endoplasmic reticulum stress: cell life and death decisions
... cell stress response, the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or ...ER stress leads to cell death ...
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Analysis of the Activities of the Inflammatory Cytokine Macrophage Migration Inhibitory Factor on Activation of Endoplasmic Reticulum Stress Responses
... ER stress as well as the UPR providing more activation potential by ATF6 and CHOP induced AKT activation (although this is cancelled out by IRS1 and mTORC2 in chronic cases) (Appenzeller-Herzog and Hall, ...
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Alginate oligosaccharide alleviates myocardial reperfusion injury by inhibiting nitrative and oxidative stress and endoplasmic reticulum stress-mediated apoptosis
... nitrosative stress, were signifi- cantly increased in the I/R group, which is consistent with previous ...this stress by downregulating the cardiac expression of 3-NT and ...oxidative stress and to ...
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Olmesartan, an AT1 Antagonist, Attenuates Oxidative Stress, Endoplasmic Reticulum Stress and Cardiac Inflammatory Mediators in Rats with Heart Failure Induced by Experimental Autoimmune Myocarditis
... oxidative stress and endoplasmic reticulum (ER) stress is not known in rats with heart failure after ...ER stress and MAPK/JNK signaling associated with ...oxidative stress, ER ...
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Endoplasmic reticulum stress and apoptosis
... A further link between the ER, p53 and apoptosis proceeds from the recent identification of a novel p53-regulated ER membrane protein named scotin. Further studies showed that scotin is conserved between mouse and human ...
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The Endoplasmic Reticulum Stress Sensor Inositol Requiring Enzyme 1α Augments Bacterial Killing through Sustained Oxidant Production
... cellular stress programs, such as the unfolded protein response (UPR), which occurs when misfolded proteins accumulate within the endoplasmic reticulum ...ER stress promotes antimicrobial ...
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Endoplasmic reticulum stress and diabetic retinopathy
... ER stress-mediated cell death is associated with the death of pan- creatic β -cells in patients with diabetes (Oyadomari et al 2001, 2002; Laybutt et al ...ER stress-induced apoptosis is related to changes ...
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Review Article Calumenin relieves cardiac injury by inhibiting ERS-initiated apoptosis during viral myocarditis
... found endoplasmic reticulum stress (ERS) reaction is a new signal transduction pathway mediating ...the endoplasmic reticulum Ca 2+ binding proteins, and is important in ...
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Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?
... antibody; ERS: Endoplasmic reticulum stress; FPG: Fasting plasma glucose; HC: Hip circumference; HLD-C: HDL cholesterol; LDL-C: LDL-cholesterol; NIDDM: Non-insulin dependent diabetes mellitus; ...
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Endoplasmic Reticulum Stress in Metabolic Disorders
... signaling, nutrient toxicity, oxidative stress) leading to inflammation and eventually to cell death.. ER stress induces IR and diabetes 15.[r] ...
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Review Article Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage
... Abstract: Steatosis is a characteristic morphological change of alcoholic liver disease, but its pathologic significance is still obscure. Regardless of cell types, intracellular lipid droplets are coated with a ...
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A comparative study of toxicity of TiO<sub>2</sub>, ZnO, and Ag nanoparticles to human aortic smooth-muscle cells
... Results: Only ZnO NPs significantly induced cytotoxicity, accompanied by increased intracel- lular reactive oxygen species, Zn ions, and endoplasmic reticulum stress biomarkers (DDIT3 expression and ...
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