Endothelial Progenitor Cell
Endothelial progenitor cell dysfunction in diabetes mellitus
... Angiogenesis describes the formation of new capillaries from already existing capillaries. It is a physiological process required postnatally for non-pathological processes like endometrial remodeling during the ...
196
CCR5 facilitates endothelial progenitor cell recruitment and promotes the stabilization of atherosclerotic plaques in ApoE−/− mice
... To investigate the effects of CCR5 overexpression on EPCs, CM-DiI-labeled EPCs were transfected by lentivirus encoded with EGFP (Lenti-EGFP) or EGFP-CCR5 (Lenti- CCR5) gene. The efficiency of the transfection in EPCs was ...
11
Estrogen and progesterone play pivotal roles in endothelial progenitor cell proliferation
... Before culturing the cells, the cEPCs were confirmed by FACS with a PE-labeled monoclonal antibody against human KDR (Genzyme Techne; Cambridge, MA), a FITC-labeled monoclonal antibody against human AC133 (Genzyme ...
8
Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine
... single cell preparation and immunohistochemistry analysis revealed that the endothelial cells constitute over ~51- 54%, hematopoietic-derived cells ~3%, and fibroblasts under equating to ~11% of the total ...
16
<p>miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice</p>
... vascular endothelial growth factor (VEGF) and angiogenin-1 (ANG- 1) and their receptors, inhibiting their ability to promote the proliferation and adhesion of ...
12
Endothelial progenitor cell number is not decreased in 34 children with Juvenile Dermatomyositis: a pilot study
... activated cell sorting ...on endothelial linage cells such as endothelial progenitor cells and mature endothelial cells; b) CD34 is a marker of stem cells, and c) these double positive ...
5
VEGF promotes endothelial progenitor cell differentiation and vascular repair through connexin 43
... vascular endothelial cells primarily express three: Cx37, Cx40, and Cx43 [18], all of which facilitate the propagation of electrical and chemical signals along the vessel ...stem cell differentiation, ...
11
Original Article Comparison of endothelial cell- and endothelial progenitor cell-derived exosomes in promoting vascular endothelial cell repair
... Timely endothelial repair after intervention-associated vascular injury is critical to prevent restenosis and ...living cell therapies, exosomes may be a better ...vein endothelial cells (HUVECs) ...
8
Endothelial progenitor cell biology in disease and tissue regeneration
... Epidemiological observations have indicated a role of hor- mones, specifically estrogen, in vascular repair and mainte- nance. Such observations include a comparative decrease of heart disease and increase in vascular ...
8
Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head
... circulating endothelial progenitor cell (EPC) numbers and functions are reduced in ANFH patients, suggesting that risk factors of ANFH may alter EPCs biology in angiogenesis and vascular repair ...
7
Decreased expression of the endothelial cell derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
... Late-outgrowth endothelial progenitor cell (EPC)-derived endothelial cells were obtained from the peripheral blood of 15 SSc patients (13 women and 2 men; n = 9 with lcSSc and n = 6 with ...
9
Original Article The association between hyperhomocysteinemia and cerebral small vessel disease
... vascular endothelial cell ac- tive factor levels, and endothelial progenitor cell (EPC) function are associated with cerebral small vessel disease ...vascular endothelial ...
7
Differential gene expression in Lin-/VEGF-R2+ bone marrow-derived endothelial progenitor cells isolated from diabetic mice
... in endothelial progenitor cell migration and function in magnetically sorted Lin − /VEGF-R2 + endothelial progenitor cells obtained from the bone marrow of Akita mice in the early ...
10
Sex Steroids and Stem Cell Function
... and endothelial progenitor ...of endothelial progenitor cells to the ischemic myocardium and enhance neovascularization at the ischemic border ...stimulate endothelial progenitor ...
9
Effects of age on noninvasive assessments of vascular function in nonhuman primates: implications for translational drug discovery
... Six fasted monkeys (17 ± 1 years of age) were treated orally with both vehicle and rosiglitazone (1 mg/kg, coated on one PrimaTreat; Bio-Serv, Frenchtown, NJ) ≥2 weeks apart in a 2 × 2 crossover design (2 in vehicle-drug ...
10
Peroxisome proliferator-activated receptors as stimulants of angiogenesis in cardiovascular disease and diabetes
... Angiogenesis is described as the formation of new capillaries from the existing vasculature. This process involves the breakdown of the extracellular matrix and formation of an endothelial tube. Angiogenesis is an ...
8
B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus
... the endothelial cell line with BLyS, we detected a pro-apoptotic effect of the cytokine on both cell ...the progenitor cells and that EPCs express IFNα/β receptors 1 and 2 ...the ...
11
Vascular stem cells in diabetic complications: evidence for a role in the pathogenesis and the therapeutic promise
... In addition to growth factors, the ECM regulates the vascular cells and may contribute to the differential effects of high glucose levels in diabetic complications. Binding of EC surface integrins to the ECM proteins ...
10
Biophysical regulation of stem cell behavior within the niche
... Many factors that are often thought of as soluble are known to harbor matrix-binding domains that immo bi- lize them to the solid phase of tissue. For example, fi broblast growth factors, platelet-derived growth factors ...
7
Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells
... of endothelial cells ...embryogenesis, endothelial and hematopoietic cells de- velop in parallel ...hemogenic endothelial cells lining the aortic floor both in murine and zebrafish [10, ...of ...
13