epigenetic modifications
Epigenetic modifications in rheumatoid arthritis
... such as let-7 in non-small lung cancer cells [59] or of miR-15 and miR-16 in chronic lymphocytic leukemia [60] have been found to be implicated in tumor- genesis. Most strikingly, there is increasing evidence that ...
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Epigenetic modifications of chronic hypoxia mediated neurodegeneration in Alzheimer’s disease
... [56]. Epigenetic regula- tion is a strong candidate therapeutic, since epigenetic modifications are reversible while genetic mutations are ...translational modifications of histones are ...
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Epigenetic modifications in essential hypertension
... [33]. Epigenetic modifications, in the form of up-regulated H3K27me3 expression was observed in the renal artery of a salt-sensitive hypertension model of the Wistar rat [33], possibly correlating with the ...
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Epigenetic modifications in essential hypertension
... DNA Methylation & Hypertension Epigenetic Modifications in Essential Hypertension Ingrid Wise Faculty of Science and Technology PhD supervisor Prof Fadi Charchar Associate supervisors Dr Scott Nankerv[.] ...
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Role of epigenetic modifications in inflammation and cancer
... of epigenetic modifications in cancer Abbberant histone modifications are observed in various cancers in humans and various studies have shown that more than 300 genes are altered by ...
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Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology
... Waldenstrom’s Macroglobulinemia is a low-grade B-cell lymphoma characterized by the presence of lymphoplas- macytic cells in the bone marrow and a monoclonal immunoglobulin M in the circulation. Recent evidences sup- ...
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The Polo-like kinases as recipients and enablers of epigenetic modifications in tumourigenesis
... gene epigenetic modifications associated with malignancy have previously been documented for Plk2 where its methylation-dependent silencing was detected at a high rate in B-cell malignancies and Burkitt’s ...
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Diabetic retinopathy: reversibility of epigenetic modifications and new therapeutic targets
... Histone modifications refer to methylation, acetylation, phosphorylation, adenylation, ubiquitination, ADP-ribo- sylation, and other modifications of histones in the pres- ence of related ...
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Epigenetic modifications are associated with inter species gene expression variation in primates
... tone modifications and Pol II are truly causally related to variation in gene expression levels, they are only in- volved in some of the many intermediate steps that a complex machinery takes to convert genome ...
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Epigenetic modifications of histones in cancer
... different epigenetic states and reveal struc- tural details of chromatin ...chromatin modifications with confocal and structured illumination microscopy [207], and fluor- escent ligand labeling for direct ...
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Jones_unc_0153D_16257.pdf
... potential epigenetic regulator (12, ...describe modifications of the DNA or associated proteins that carry information during cell division, exclusive of DNA sequence variation ...understood ...
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Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?
... and epigenetic modifications (methylation, acetylation) ...genetic modifications depend on the type of cells and the microenvironment where the cells are ...
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delaPena_unc_0153D_14698.pdf
... respective transcriptional network are involved in epigenetic modifications affecting CD4 + T cell differentiation. We postulated that the preferential development of Th2 response in infants is due to ...
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Reviewing the epigenetics of schizophrenia
... extant epigenetic work, researchers might also pursue questions of the general form ‘this environmental influence is significant in schizophrenia: what epigenetic processes are associated with it?’ Studies ...
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Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy
... abnormal epigenetic modifications, such as DNA methylation, histone modification, and oxidative modification of nucleic acid, could lead to changes in chromosome structure and cardiac ...ncRNA-linked ...
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The genetics of neuroendocrine prostate cancers: a review of current and emerging candidates
... aberrant epigenetic events in PC include DNA hypo- and hypermethylation, chromatin remodeling, altered histone modifications, and changes in miRNA ...these epigenetic alterations in cancer; in ...
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The Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
... The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories including nucleosome remodeling and RNA mediated targeting have been strongly investigated recently ...
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NETs: organ-related epigenetic derangements and potential clinical applications
... multiple epigenetic modifications have been described across the whole spectrum of NETs, and their putative function as tumorigenic drivers has been ...testing epigenetic biomarkers are therefore ...
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Epigenetic Inheritance of 5-AZA-2'-Deoxycytidine (5-AZA-CdR) Induced Alterations
... acquired epigenetic modifications, such as DNA methylation or stable chromatin structures, were cleared and reset on passage through the germline [69, 78, ...such epigenetic modifications ...
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The struggle for life of the genome's selfish architects
... In addition, we have also recently shown that transposable element mediated epi- genetic effects on host genomes may not be confined to repressive epigenetic modifications, as emphasized[r] ...
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