Epigenetic silencing
Epigenetic silencing and deletion of the BRCA1gene in sporadic breast cancer
... that epigenetic silencing of the BRCA1 gene might chan- nel tumour progression, akin to an underlying BRCA1 germ- line mutation resulting in a BRCA-like ...
10
c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis
... activates the MAPK/Erk signaling, resulting in upregulation of its downstream effector c-Myc in many types of cancer particularly thyroid cancer and melanoma. In general, c-Myc is degraded via the ubiquitin-proteasome ...
16
Original Article Epigenetic silencing of miR137 in gastric cancer
... miR137 was also reported in human gastric carcinoma tissues [17]. In this study, we found promoter methylation of miR137 was indeed responsible for its epigenetic silencing in gas- tric cancer cells. ...
7
Epigenetic silencing of MEIS2 in prostate cancer recurrence
... Although epigenetic silencing of MEIS2 has also been described in lung and hepatocellular carcinoma cell lines as well as colorectal cancer [39–41], the function of MEIS2 in other cancers remains unclear ...
14
Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors
... of epigenetic silencing in colorectal tumors, despite it functions as an ...and epigenetic alterations occurring to NTSR1 during tumor progression by analyzing a mixed colorectal lesion consisting of ...
16
Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancer
... Epigenetic biomarker studies are focused on analyzing the methylation changes in the promoter regions of candi- date genes in specific tumor types for the implication in gene silencing [9, 34]. In general, ...
16
Role of microRNAs in epigenetic silencing of the CHD5 tumor suppressor gene in neuroblastomas
... of epigenetic regulation of genes, including DNA methylation, histone modification, and microRNA ...for silencing of the remaining allele of TSGs in cancers in which one copy is deleted, but the remaining ...
9
Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma
... Results: TMEM176A was highly expressed in SNU387, SNU182, Huh1, and SNU475 cells; reduced expression was.. observed in HepG2 and PLC/PRF/5 cells; and no expression was found in SNU449, H[r] ...
15
Epigenetic silencing of miR-145-5p contributes to brain metastasis
... combined epigenetic therapy with 5-azacytidine and entinostat, inhibitors of DNA methylation and histone deacetylation, respectively, within a phase I/II trial in patients with recurrent metastatic NSCLC was well- ...
19
Common themes in siRNA mediated epigenetic silencing pathways
... dependent silencing of gene expression (Fig. 1). SiRNA-mediated silencing pathways are activated by double-stranded RNAs that are processed into siRNAs by Dicer, a type III ...RNAi-Induced Silencing ...
14
Epigenetic silencing of DSC3 is a common event in human breast cancer
... To determine if DSC3 expression is lost in association with aberrant methylation of the DSC3 promoter we used sodium bisulfite genomic sequencing to assess the cytosine methyla- tion status of the DSC3 promoter region. ...
12
DNA methylome analysis identifies epigenetic silencing of FHIT as a determining factor for radiosensitivity in oral cancer: an outcome-predicting and treatment-implicating study
... Oral cancer cell lines OML1, OCSL , SAS (obtained from Dr. Yong-Kie Wong, Department of Dentistry, Taichung Veterans General Hospital, Taichung, Taiwan) were propagated with RPMI Medium 1640 (Gibco, Grand Island, NY) ...
20
Review Article Epigenetics and Epigenetic Alterations in Pancreatic Cancer
... the epigenetic silencing of certain tumor suppressor genes [56, 160, 161], and some studies indicate that cancers of older patients have more aberrant methylation than those in younger patients ...that ...
17
Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Helen M. Coley 1, Eleftheria Hatzimichael2 , Sarah Blagden 3, Iain McNeish4 , Alastair Thompson 5, Tim Crook5 and Nelofer Syed 6
... to epigenetic silencing in carboplatin resistance in vitro and in vivo, emphasising that cell cycle regulators are important determinants of sensitivity to chemotherapeutic agents and providing insights ...
6
Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
... of epigenetic regulation of macropinocytosis in these fibroblasts (Supplemental Figure ...The epigenetic silencing of RASAL3 in CAF correlated with Ras-mediated macropinocytosis and subsequent ...
14
NET23/STING promotes chromatin compaction from the nuclear envelope
... by epigenetic modification of chromatin [47], the observed chromatin compaction induced by NET23/STING might be mediated by epigenetic silencing ...to epigenetic marks at 21 and 85 h post- ...
19
Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family
... Tandem C2H2-type zinc finger proteins (ZFPs) constitute the largest transcription factor family in animals. Tandem-ZFPs bind DNA in a sequence-specific manner through arrays of multiple zinc finger domains that allow ...
20
Characterizing DNA methylation alterations from The Cancer Genome Atlas
... The Cancer Genome Atlas (TCGA) Research Network is a multi- institutional consortium aimed at performing comprehensive molecular profiling of 10,000 primary tumors spanning 30 can- cer types (Table 1). Molecular ...
8
Epigenetic gene silencing in cancer
... of epigenetic silencing via gene ...gene silencing in diverse species, and, in organisms with functional methyltransferases, this process is often associated with extensive de novo ...(36). ...
8
Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons
... Beside histone deacetylation we identified a rapid but transient increase in inhibitory H3K9me3 over the first 3 h following the glutamatergic excitation. Although H3K9me3 is mostly recognized for its role in stabilizing ...
14