Epithelial Sodium Channel
Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene
... the epithelial sodium channel (ENaC) have been found to cause a hereditary form of human hypertension, Liddle ...the channel, suggesting that these domains are important for the normal ...
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Salt sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel
... (20HETE) by the epoxygenase and ωhydroxylase branches of the cytochrome P450 (P450) AA monooxygenase is well established (8, 9) as are the biological activities of these metabolites (9–11). Earlier studies identified ...
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Low Expression of Human Epithelial Sodium Channel in Airway Epithelium of Preterm Infants With Respiratory Distress
... of epithelial sodium channel (ENaC) in this clearance has been demonstrated in animal studies in which ␣-ENaC knockout mice died postnatally as a result of respiratory ...
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Expression of the Epithelial Sodium Channel in Airway Epithelium of Newborn Infants Depends on Gestational Age
... The epithelial sodium channel is considered rate limiting for the postnatal clearance of lung liquid, but it is unknown whether during the early postnatal period the expression of epithelial ...
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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice
... of sodium transport in target epithelia and contributes to the control of blood pressure and cardiac ...of sodium from tubular fluid via regulation of the α subunit of the epithelial sodium ...
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Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa
... The epithelial sodium channel (ENaC) is expressed in epi- thelial cells of several tissues involved in salt and water ...The channel is composed of three related subunits (α, β, γ) that are ...
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17β-estradiol suppresses lipopolysaccharide-induced acute lung injury through PI3K/Akt/SGK1 mediated up-regulation of epithelial sodium channel (ENaC) in vivo and in vitro
... Background: 17 β -estradiol can suppress acute lung injury (ALI) and regulate alveolar epithelial sodium channel (ENaC). However the relationship between these two functions remains unclear. This ...
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Could a defective epithelial sodium channel lead to bronchiectasis
... amiloride-sensitive epithelial sodium channel (ENaC) allows passive transport of sodium into the ...in epithelial cells lining the renal tubule, the respiratory airways and alveoli, the ...
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Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC
... the Epithelial Sodium Channel ...calcium channel trafficking to the plasma membrane in tsA-201 ...Cav3.2 channel expression also enhanced β -ENaC trafficking to the cell ...
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Liddle syndrome due to a novel mutation in the γ subunit of the epithelial sodium channel (ENaC) in family from Russia: a case report
... The younger sister (14 years old, 46 kg, 162 cm) of proband had normal BP (120/80 mmHg) with a periodic increase to 160/100 mmHg. From 12 years, she has been complaining of headache and nausea in the morning. She had a ...
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Mutations causing Liddle syndrome reduce sodium dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system
... Na 1 -dependent regulation of ENaC may require a sensor for Na 1 activity. This sensor could theoretically be either in ENaC itself or in another protein that would transmit the sig- nal by direct interaction with ENaC ...
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Airway Expression of the Epithelial Sodium Channel -Subunit Correlates With Cortisol in Term Newborns
... airway epithelial sampling; ENaC expression and gestational age were significantly correlated only in infants delivered by CD from whom the first specimens were collected within 30 minutes post- ...
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nejm199907153410304.pdf
... the epithelial sodium-channel subunits, no sodium absorption from airway surfaces, and a volume of airway surface liquid that was more than twice the normal ...
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Alveolar epithelial fluid clearance is mediated by endogenous catecholamines at birth in guinea pigs
... the epithelial sodium channel mRNA in the newborn lung that rapidly tapered off toward adult ...amiloride-sensitive sodium trans- porting pathways for clearance of fetal lung fluid at ...
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Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway
... Background: Pulmonary edema is one of the pathological characteristics of acute respiratory distress syndrome (ARDS). The epithelial sodium channel (ENaC) is thought to be the rate-limiting factor ...
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Journal of Applied Pharmaceutical Science
... Imbalance oxidative status occurs when oxidative stress is higher in the body due to the production of reactive oxygen species. Thus, antioxidants are needed to counteract the production of free radicals. Reoccurrence of ...
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annalsats.201806-368aw.pdf
... the epithelial sodium channel (bENaC-Tg), producing a CF-like increase in airway sodium/fluid absorption, demonstrated that airway surface dehydration is sufficient to produce early-onset mucus ...
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Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes
... potassium channel (Wilson et ...the epithelial sodium channel (ENaC) (Trujillo et ...conductance sodium channel consisting of various combinations of three subunits: a, b and g ...
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Ibuprofen-Induced Patent Ductus Arteriosus Closure: Physiologic, Histologic, and Biochemical Effects on the Premature Lung
... RESULTS. After treatment was started, the ibuprofen group had significantly lower pulmonary/systemic flow ratio, higher systemic blood pressure, and lower left ven- tricular end diastolic diameter, compared with the ...
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WNK pathways in cancer signaling networks
... EMT: Epithelial to mesenchymal transition; ENaC: Epithelial sodium channel; ES cells: Embryonic stem cells; HCC: Hepatocellular carcinoma; HEK293: Human embryonic kidney 293; IgA: ...
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