Epithelial to mesenchymal transition
Epithelial to mesenchymal transition and breast cancer
... Introduction For almost two decades the prospect that recapitulation of the developmental process called epithelial to mesenchymal transition (EMT) may play an important role in carcinoma progression ...
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Epithelial to mesenchymal transition is associated with rapamycin resistance
... that epithelial-to-mesenchymal transition (EMT) confers rapamycin ...the epithelial marker E-cadherin protein is higher in rapamycin sensitive (RS) cells and mesenchymal breast cancer ...
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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
... the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer ...fully epithelial cells to enter into a series of phenotypic states arrayed along the ...
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Epithelial to Mesenchymal Transition of Mesothelial Cells in Tuberculous Pleurisy
... whether epithelial to mesenchymal transition (EMT) of mesothelial cells occurs in tuberculous ...phenotypic transition from epithelial to mesenchymal cells, with the loss of ...
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ZEB1 drives epithelial to mesenchymal transition in lung cancer
... in epithelial-to-mesenchymal transition ...bronchial epithelial cells (HBECs) and determined that EMT and ZEB1 expression are early, critical events in lung cancer ...repressed ...
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The Significance of Epithelial-to-Mesenchymal Transition for Circulating Tumor Cells
... cells; epithelial to mesenchymal transition; marker; prognosis; cancer; metastasis ...of epithelial origin change their properties, like cell adhesion, cell mobility, and invasiveness, and ...
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Attenuation of early liver fibrosis by herbal compound “Diwu Yanggan” through modulating the balance between epithelial to mesenchymal transition and mesenchymal to epithelial transition
... of epithelial-to-mesenchymal transition (EMT) to mesenchymal-to-epithelial transition (MET) in the fibrotic liver tissues, which was characterized with the up-regulation ...
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Eribulin Does Not Prevent Epithelial-to-Mesenchymal Transition in HT-29 Intestinal Epithelial Cells
... become mesenchymal-like myofibroblasts, IEC must undergo conversion in a process called epithelial- to-mesenchymal transition ...ated epithelial cells acquire a mesenchymal ...
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Vitamin D and the epithelial to mesenchymal transition
... an epithelial phenotype, while those shown in red are related with a mesenchymal ...the mesenchymal phenotype is maintained during disease ...
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Mechanisms and drivers of epithelial to mesenchymal transition in COPD
... entire epithelial layer with reasonable uniformity, this distinction is likely unimportant, N-cadherin and S100A4 demonstrated more discrete, point staining and, at least in the case of N-cadherin, appeared to ...
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TGFβ and matrix-regulated epithelial to mesenchymal transition
... breast epithelial cells upon EMT, and the function of Hic-5 requires Src-dependent tyrosine phosphorylation and cooperation with the small GTPase ...the mesenchymal protein lipoma preferred partner (LPP) is ...
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Intermediate cell states in epithelial-to-mesenchymal transition
... Further work in the mammary model in vivo found that Snai2 (Slug) is the major EMT-TF expressed in mouse mammary basal cells known to contain multi- potent stem cells, and that ectopic expression of Snai2 leads to ...
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Disabled-2 downregulation promotes epithelial-to-mesenchymal transition
... normal epithelial cells, strategies targeting TGFb2 isoform expression may provide the specificity required to block only the pro-metastatic functions of the TGFb signalling ...
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Novel clinical therapeutics targeting the epithelial to mesenchymal transition
... 2. Metformin Small molecule inhibitors offer the potential for future therapeutic options against difficult to treat malignan- cies, particularly those which demonstrate treatment re- sistance. The transition from ...
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C-phycocyanin inhibits epithelial-to-mesenchymal transition in Caski cells
... In our study, we investigated the effect of C-phycocy- anin on TGF-β-induced epithelial mesenchymal trans- formation in cervical cancer Caski cells, and revealed the molecular mechanism of its anticancer ...
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Epithelial-Mesenchymal Transition in tumor microenvironment
... cell Epithelial-Mesenchymal Transitions (EMT) in tumor ...hypoxia, mesenchymal stem cells all can effectively lead the epithelial-to-mesenchymal transition (EMT) of tumor ...
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Epithelial mesenchymal transition and its implications for fibrosis
... 2 Departments of Medicine and Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Epithelial to mesenchymal transition (EMT) is a central mechanism for ...
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OVOL guides the epithelial-hybrid-mesenchymal transition
... of Epithelial-to-Mesenchymal Transition (EMT) and its ...hybrid epithelial/mesenchymal (E/M) phenotype that has maximum cellular plasticity and allows migration of Circulating Tumor ...
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Epithelial mesenchymal transition, cancer stem cells and treatment resistance
... in epithelial-to-mesenchymal transition and stem cell ...Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and ...
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The basics of epithelial mesenchymal transition
... of mesenchymal phenotype, the mechanisms of EMT induction and progression vary dramatically from one setting to ...activated mesenchymal cells, notably myofibroblasts that produce excessive amounts of col- ...
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