epithelial transforming growth factor
Interactions between stromal cell derived keratinocyte growth factor and epithelial transforming growth factor in immune mediated crypt cell hyperplasia
... both growth factors, after electrophoresis and transfer to nitrocellulose membrane, nonspecific binding was blocked by incubating the membrane in 5% nonfat milk/PBS-T (PBS, ...
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Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells
... As expected, exposure to TGF-β1 resulted in significant enrichment of the ECM turnover (Fig. 8a), alveolar epithe- lial cell dysfunction, and skin fibrosis pathways as deter- mined by GSEA (Table 4). It is well known ...
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Induction by transforming growth factor β1 of epithelial to mesenchymal transition is a rare event in vitro
... The human breast epithelial cell line MCF10A did not become elongated (Fig. 3a,e) or lose junctional E-cadherin or ZO-1 staining (Fig. 3b,f,c,g) in response to 48 hours of TGF-β1 treatment. After treatment, these ...
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Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells
... of transforming growth factor alpha (TGF alpha), and transforming growth factor beta (TGF beta) was assessed in isolated primary rat intestinal epithelial cells as well as ...
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Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1
... In this study, we have demonstrated that TGF-β potently induces insensitivity to glucocorticoid transactivation in epithelial cells, without impacting on glucocorticoid trans- repression. Demonstration of the ...
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Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors
... (ameloblastic fibromas), TGF beta 2 mRNA was mostly located in the mesenchymal tumor component and protein in the epithelial tumor component. Odontogenic ectomesenchymal tumors (myxomas) were not associated with ...
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Tumor-associated macrophage-derived cytokines enhance cancer stem-like characteristics through epithelial–mesenchymal transition
... recurrence. Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells lose their epithelial phenotype and convert to mesenchymal ...as transforming growth ...
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Breast cancer growth and metastasis: interplay between cancer stem cells, embryonic signaling pathways and epithelial to mesenchymal transition
... of epithelial-to-mesenchymal ...and transforming growth factor (TGF)-β signaling can activate epithelial-to-mesenchymal transition (EMT) regulators to induce phenotypic changes through ...
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The JAK2 pathway is activated in idiopathic pulmonary fibrosis
... with transforming growth factor beta 1 or interleukin (IL)-6/IL-13 activated JAK2 and STAT3, inducing epithelial to mesenchymal and fibroblast to myofibroblast ...
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Lack of transforming growth factor β signaling promotes collective cancer cell invasion through tumor stromal crosstalk
... and epithelial cells by promoting fibro- blast transdifferentiation into invasive myofibroblasts and by driving an epithelial-to-mesenchymal transition (EMT) frequently associated with invasive tumors ...as ...
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Transforming growth factor-β1 treatment of oral cancer induces epithelial-mesenchymal transition and promotes bone invasion via enhanced activity of osteoclasts
... When epithelial neoplasms metastasise to bone, a vicious circle is established between the malignant cells themselves, and bone ...release growth factors from the bone matrix, which then stimulate tumour ...
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Current progress in understanding the molecular pathogenesis of burn scar contracture
... and epithelial cells, secrete transforming growth factor- β 1 (TGF- β 1) and other cytokines, which can promote persistent myofibroblast activation via a positive regulation ...initiation ...
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Transforming growth factor-β1/Smad3-independent epithelial–mesenchymal transition in type I collagen glomerulopathy
... of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial–mesenchymal transition (EMT) in this ...parietal epithelial cell proliferation and EMT in late ...
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Quercetin inhibits transforming growth factor β1-induced epithelial–mesenchymal transition in human retinal pigment epithelial cells via the Smad pathway
... their epithelial phenotype to one with mesenchymal characteristics, and the proliferation, migration, and collagen generation of TGF- β 1-induced RPE cells are enhanced, accelerating EMT ...
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Regulation of transforming growth factor expression in rat intestinal epithelial cell lines
... increased expression of beta-actin when standardized to a constitutive transcript (GAPDH). Similar responses to addition of EGF and TGF beta 1, were observed in another intestinal epithelial cell line, designated ...
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Transforming growth factor beta-1 expression in macrophages of human chronic periapical diseases.
... regulatory factor with multiple functions, TGF-b1 participates in several important pathophysiological processes, and is currently studied ...tissue growth factor (CTGF) and TGF-b1 levels in hepatic ...
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A Tale of Breast Cancer, Behavior and Brains as Affected by Diet and Claudins
... main epithelial plate; this is the hollowing out ...out growth and elongation the fat pad and stroma are ...5). Transforming growth factor (TGF) promotes the synthesis of ECM and build ...
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Mitogenic response of canine fundic epithelial cells in short term culture to transforming growth factor alpha and insulinlike growth factor I
... epidermal growth factor and transforming growth factor alpha (TGF alpha) (10 pM to 1 nM), insulin (10 nM to 1 microM) and insulinlike growth factor-I (IGF-I, 1-100 nM) ...
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Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancer
... termed epithelial-mesenchymal transition (EMT), a phenotypic change in which epithelial cells acquire mesenchymal ...including transforming growth factor (TGF)- β , and recent studies ...
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Obstructive renal injury: from fluid mechanics to molecular cell biology
... Progressive interstitial fibrosis is the most dramatic conse- quence of chronic obstructive nephropathy, and is the final common pathway of all forms of CKD. Fibrosis is charac- terized by increased numbers of activated ...
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