ER-α
DAX 1 expression in human breast cancer: comparison with estrogen receptors ER α, ER β and androgen receptor status
... For Western blot analysis, tissues were homogenized in extraction buffer (10 mM Tris-HCl, pH 7.6, 10 mM KCl, 1 mM 1,4-dithiothreitol, and 0.2 M EDTA, pH 8) in addition to a cocktail of protease inhibitors (1 mM ...
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Shabani, Naim (2008): Prognostische Signifikanz der Expression von Estrogenrezeptor alpha (ER-α) und beta (ER-β), Progesteronrezeptor A (PR-A) und B (PR-B) in Endometriumkarzinomen. Dissertation, LMU München: Medizinische Fakultät
... Das Endometriumkarzinom ist eines der häufigsten gynäkologischen Malignome und macht circa 6% aller bösartigen Neubildungen bei Frauen aus. Das humane Endometrium exprimiert Estrogen- (ER) und ...
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Original Article The cervical malignant cells display a down regulation of ER-α but retain the ER-β expression
... and ER-β). In this study we investigated the expression of ER-α and ER-β in human invasive cervical carcinomas using immunohistochemistry and RT-PCR analyses and com- pared with that observed ...
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Estradiol’s Salutary Effects on Keratinocytes Following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)-α and ER-β
... Although the present findings showed the salutary effects of PPT and DPN in keratinocyte cytokine production after trauma-hemorrhage, the precise mecha- nism by which this occurs remains un- known. MAPKs play an ...
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Interleukin-6 is a potential therapeutic target in interleukin-6 dependent, estrogen receptor-α-positive breast cancer<div><br /></div>
... that ER α -positive breast tumor models, when biased toward estrogen supported growth, demonstrate IL-6 ...with ER α -positive breast tumors (cell lines or patient-derived xenografts), which ...
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Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells
... As previous studies have revealed that estrogens may regulate the focal adhesion complexes not only through the classical estrogen receptor α (ER α ) in breast tumor and endothelial cell[r] ...
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The regulation of steroid receptors by epigallocatechin-3-gallate in breast cancer cells
... A cell viability assay shows the amount of live cells in a population after treatment with ligands, at varying concentra- tions, for a 6-day duration. To determine the cellular influence of EGCG, image cytometric ...
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ER-α36: a novel biomarker and potential therapeutic target in breast cancer
... traditional ER-α (ER-α66). ER-α36 primarily locates on plasma membrane and cytoplasm and functions as a mediator in the rapid membrane-initiated non-genomic signaling ...by ER-α66 in a ...
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Hochu-Ekki-to Treatment Improves Reproductive and Immune Modulation in the Stress-Induced Rat Model of Polycystic Ovarian Syndrome
... NGFR, ER-α, and ER-β, but not GR, were higher in the proestrous group than in the diestrous group ...of ER-α and ER-β relative to both control groups ...AR, ER-α, ...
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Metabolic properties of the osteoclast
... osteoclasts and their mononuclear progenitor cells [65,32]. Knockdown of HIF-1α is reported to abolish resorption pit formation in normoxic cultures of osteoclast-forming mouse marrow cells [24]. HIF-1α knockdown has ...
21
Estrogen rescues heart failure through estrogen receptor Beta activation
... The improvement of heart function in HF mice treated with ER β agonist DPN was also associated with reduced cardiac fibrosis and increased cardiac angiogenesis, while the ER α agonist PP[r] ...
11
Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer
... In conclusion, we fi nd that oestrogens increase severity of colitis and colitis-associated cancer development. Both Er α and Er β are required for the tumour-promoting role of oestrogens. The ...
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Original Article The expression of transcription factor BORIS and its association with the estrogen receptor beta (ER-β) in cervical carcinogenesis
... of ER-α in the cervical squamous epithelium, but not in the HSIL or SC, coinciding with previous reports [6, 7, 32-34], except for some cases of CC with ER-α expression in stromal cells but ...
14
ER-α36 mediates cisplatin resistance in breast cancer cells through EGFR/HER-2/ERK signaling pathway
... of ER superfamily with molecular weight 36 kDa, is a recently identified ER-α66 variant ...[11]. ER-α36 is responsible for estrogen-stimulated cell proliferation and development of ER-positive ...
11
The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cells
... [2,10,11,13,14]. ER α -positive breast cancer cells usually express Bcl-2, whereas ER α -negative ones express little or no Bcl-2 ...to ER α -mediated ...that ER α ...
10
Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls
... of ER-α in relation to adolescent breast development in ...the ER-α gene (ESR1) have been associated with the increased percent fibroglandular volume (%FGV) in pre- and post- menopausal women ...
12
Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer
... both ER-α Ser118 and ER-α Ser167 occurs in response to either estradiol binding or activation of growth factor signaling ...activate ER- α , in the absence of its lig- and, ...
12
Seel, Nina Nicola (2012): Expression des Östrogenrezeptors beta beim humanen duktalen Pankreasadenokarzinom und Inhibition der Tumorprogression durch Einsatz des selektiven Östrogenrezeptormodulators Raloxifen. Dissertation, LMU München: Tierärztliche Fakultät
... In früheren Studien wurde gezeigt, dass Raloxifen (RAL) an ER α und ER β gleichermaßen mit ähnlicher Affinität bindet [153]. Dabei agiert Raloxifen am ER α als Agonist/Antagonist und[r] ...
117
-SYN and ER 3in normal ovarian tissue and ovarian tumours. In high-grade
... full-length ER function (Hartenbach et ...into ER splice variants in ovarian tissues and, of the ERα variants, only ER α ∆4 and ER α ∆5 have been shown to be present (Erenburg et ...
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Protective Effects of Female Reproductive Factors on Lauren Intestinal Type Gastric Adenocarcinoma
... This study had the limitation of being a clinicoepidemiolog- ical study without investigating the molecular mechanism of female sex hormones. Further studies are also needed to elu- cidate the biological role of estrogen ...
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