ER associated degradation (ERAD)
ER associated degradation is required for vasopressin prohormone processing and systemic water homeostasis
... are associated with physiological imbalances that underlie ...the ER remains largely ...the ER requires the ER-associated degradation (ERAD) activity of the Sel1L-Hrd1 ...
17
Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age associated obesity
... the ER over the lifetime of an organism. Disruption of ER homeostasis is a hallmark of several pathologies, including metabolic disorders and neurodegenerative diseases ...the ER consist mainly of ...
17
Braun, Sigurd (2005): ER-associated degradation (ERAD): Novel components and cellular regulation. Dissertation, LMU München: Fakultät für Biologie
... their degradation. The endoplasmic reticulum (ER) forms a specialized compartment for protein folding and maturation and about 20% of the human genes have been predicted to encode for secretory proteins ...
107
Reduction of HIV-1 Infectivity through Endoplasmic Reticulum-Associated Degradation-Mediated Env Depletion
... gp160 degradation during viral production obtained by using the targeted ER-associated degradation (TED) ...the ER-associated deg- radation pathway (ERAD) machinery to ...
6
Yeast Mutants Deficient in ER-Associated Degradation of the Z Variant of Alpha-1-Protease Inhibitor
... We chose a genetic approach to address this problem and report here the isolation and genetic characterization of yeast mutants deficient in the degradation of alpha 1-p[r] ...
8
Distribution of the SELMA Translocon in Secondary Plastids of Red Algal Origin and Predicted Uncoupling of Ubiquitin-Dependent Translocation from Degradation
... recycled ER-associated degradation (ERAD) machinery of symbiont origin ...symbiont-specific ERAD components encoded on the nucleomorph of the cryptophyte Guillardia theta, this being ...
10
Membrane Heredity Composed by Symbiogenesis
... the ER-associated degradation (ERAD) transport machinery of the endoplasmic reticulum, (ii) the peroxisomal importomer and (iii) SELMA, the pre- protein translocator of complex ...
7
<p>Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM</p>
... which ER homeostasis is disrupted by physiological factors such as heat shock, mitochondrial cal- cium overload, 19 or a high-fat ...the ER which is called the unfolded protein response ...R-like ER ...
12
Human Cytomegalovirus Tropism Modulator UL148 Interacts with SEL1L, a Cellular Factor That Governs Endoplasmic Reticulum-Associated Degradation of the Viral Envelope Glycoprotein gO
... in ER-associated degradation ...ing ERAD, small interfering RNA (siRNA) silencing of either SEL1L or its partner, Hrd1, was carried out in the context of ...these ERAD fac- tors ...
19
Diverse roles of endoplasmic reticulum stress sensors in bacterial infection
... ; ER: endoplasmic reticulum; ERAD: ER-associated degradation; ESAT-6: early secretory antigenic target 6; Grp94: heat shock protein 90 kDa beta member 1; I κ B: inhibitor of kappa B; ...
6
How Viruses Hijack the ERAD Tuning Machinery
... conventional ER and secretory pathway markers in virus-induced ER-derived membranes has for a long time hampered a thorough understanding of their ...and ER-associated degradation ...
5
Characterization of Protein Body Related Ubiquitination in Maize Endosperm Mutants.
... the ER rather than being secreted into storage protein ...less ER protein accumulation was observed in the other BiP overexpression study (Park et ...the ER and transported to the plasma membrane ...
239
Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.
... the ER and is involved in regulating morphological changes to the ...the ER and other organelles are not fully ...the ER and cellular components other than mitochondria and the PM ...the ER ...
30
Arms Race between Enveloped Viruses and the Host ERAD Machinery
... for ERAD to target viral glycoproteins for degradation: ERManI-mediated, which targets HIV-1 Env, and EDEM-mediated, which can targets HCV and HBV surface ...are ER-lumenal proteins, although the ...
20
Tamoxifen Inhibits ER-negative Breast Cancer Cell Invasion and Metastasis by Accelerating Twist1 Degradation
... Twist1 degradation and inhibit cell invasion and metastasis in ER-negative breast cancer cells and that used to inhibit ER-positive breast cancer cells in vitro and in ...Twist1 degradation in ...
11
Model Associated with the Study of the Degradation Based on the Accelerated Test: A Literature Review
... activation energy, AF temp ( ) = AF temp temp ( , U , Ea ) will be used to denote a time-acceleration factor. The Arrhenius-based model presents some limits. Indeed, the Arrhenius equation can be used to quantify the ...
15
Multiple C2 domains and Transmembrane region Proteins (MCTPs) tether membranes at plasmodesmata
... GFP-AtMCTP4- associated gold particle signal was seen along the length of the channel and neck region (Fig ...labelling associated with plasmodes- ...systematically associated (Fig 5C, Appendix Fig ...
26
Characterization of convective rain in Klang Valley, Malaysia
... Analysis of Convective Structures that Produce Heavy Rainfall Events in Catalonia (NE of Spain), Using Meteorological Radar.. Proceedings of ERAD.[r] ...
14
Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
... protein degradation, leading to accumulation of p62-mediated protein aggregates and enhanced oxidative and ER stress in acinar cells, but none of these effects is related to ...prevented ER and ...
14
An Unusual ERAD-Like Complex Is Targeted to the Apicoplast of Plasmodium falciparum
... yeast, ERAD substrates are generally recognized on the basis of distinct N-glycan modifications ...for ERAD recognition could differ from that common in ...parasite’s ER, recognition of apERAD ...
12