ER, endoplasmic reticulum
The Effect of Amygdalin on Endoplasmic Reticulum (ER) Stress Induced Hepatic Steatosis in Mice
... the ER homeostasis pathway decreases the very low-density lipoprotein (VLDL) level, increases the degradation of lipoprotein B100, and alters the lipid related transcription factors (6, ...an ER stress ...
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<p>Genetics of COPA syndrome</p>
... ; ER, endoplasmic reticulum; IL-6, interleukin 6; IRE1 α , inositol-requiring 1 α ; NF- κ B, nuclear factor- κ B; PERK, protein kinase (PKR)-like ER kinase; ROS, reactive oxygen species; ...
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The androgen receptor as an emerging target in hepatocellular carcinoma
... GRP78/Bip eR stress and HCC development 86,92 Abbreviations: ARG, androgen-responsive gene; CYP, cytochrome P450; eR, endoplasmic reticulum; HCC, hepatocellular carcinoma; TGF-β1, transforming ...
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Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress
... protein; ER: Endoplasmic reticulum; ERS: Endoplasmic reticulum stress; FCM: Flow cytometry; FITC: Fluorescinisothiocyate; GRP78: Glucose-regulated protein 78; H/R: ...
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Endoplasmic reticulum mitochondria tethering in neurodegenerative diseases
... protein; ER: Endoplasmic reticulum; FACL4: Long-chain-fatty-acid-CoA ligase 4; Fis1: Mitochondrial fission 1 protein; FTD: Frontotemporal dementia; FUS: Fused in sarcoma; grp75: Glucose-regulated ...
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Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
... ; ER: Endoplasmic Reticulum; HCQ: Hydroxichloroquine; HIF-1: Hypoxia Inducible Factor-1; HSF1: Heat Shock Factor 1; HSP90: Heat shock protein 90; ICD: Immunogenic dell death; Keap1: kelch like ECH ...
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The endoplasmic reticulum in plant immunity and cell death
... of ER stress signals might regulate separate functions of IRE1, and timely coordinated on- and offset of ATF6, PERK, and IRE1 signaling may play a decisive role in determining cell ...nario, ER stress would ...
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BiP and Multiple DNAJ Molecular Chaperones in the Endoplasmic Reticulum Are Required for Efficient Simian Virus 40 Infection
... the ER, was pelleted, whereas virus that had exited the ER and entered the cytoplasm was in the ...the ER, there was only a small amount of VP1 in the cytoplasm of either control or knockdown cells ...
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Endoplasmic reticulum stress and oxidative stress: A vicious nexus implicated in bowel disease pathophysiology
... PERK, a type-1 ER-associated transmembrane protein, manages serine/threonine protein kinase activity via its cytoplasmic domain [6]. Similar to IRE1, it is attached to GRP78, and therefore remains in an ...
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Serum glycomarkers of endoplasmic reticulum and lysosomal-endosomal system stress in human healthy aging and diseases
... in ER with ...the ER membrane and must be converted into Man 5 GlcNAc 1 during dolichol-mediated gly- cosylation, an increasing of concentration of free Man 4 GlcNAc 1 means that it cannot be transformed ...
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A microplate technique to simultaneously assay calcium accumulation in endoplasmic reticulum and SERCA release of inorganic phosphate
... The standard trace 45 Ca 2+ accumulation assay mea- sures the net luminal influx of Ca 2+ . Experimentally, the net amount of 45 Ca 2+ that accumulates over time is due to SERCA-dependent uptake counterbalanced by loss ...
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Generation of distinct signaling modes via diversification of the Egfr ligand processing cassette
... The Epidermal growth factor receptor (Egfr) pathway in Drosophila triggers a wide range of cellular responses depending on the tissue context, including determination of cell fates, cell proliferation and protection from ...
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Mechanisms of the noxious inflammatory cycle in cystic fibrosis
... Multiple evidences indicate that inflammation is an event occurring prior to infection in patients with cystic fibrosis. The self-perpetuating inflammatory cycle may play a pathogenic part in this disease. The role of ...
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Endoplasmic reticulum stress in lung disease
... PERK activates the third arm of the UPR. It is regulated in a manner similar to IRE1, but once activated PERK recruits and phosphorylates the translation initiation factor eIF2 α [38] (figure 1). Reports that PERK can ...
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Intracellular Interaction of Simian Immunodeficiency Virus Gag and Env Proteins
... the endoplasmic reticulum (ER) can alter the site of virus assembly, we coexpressed the simian immunodeficiency virus (SIV) Gag protein and mutant SIV Env proteins having an ER retrieval ...
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Fibrinogen storage disease in a Chinese boy with de novo fibrinogen Aguadilla mutation: Incomplete response to carbamazepine and ursodeoxycholic acid
... Fibrinogen, synthesized in the liver, is the focal point of the coagulation cascade. The mature circulating molecule is a dimer, with each half composed of 3 polypeptide chains (Aα, Bβ, and γ) encoded by 3 different ...
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Original Article Endoplasmic reticulum stress-mediated apoptosis signal pathway is involved in sepsis-induced liver injury
... the ER chaperone ...three ER-localized protein sensors, namely, PERK, ATF6, and ...the ER lumen, then the GPR78 dissociates from the ER stress trans- ducers to combine unfolded proteins, ...
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Endoplasmic Reticulum Stress Caused by Lipoprotein Accumulation Suppresses Immunity against Bacterial Pathogens and Contributes to Immunosenescence
... sulfonate (EMS)-mutagenized haploid genomes resulted in the isolation of seven dominant mutants with enhanced green fluorescent protein (GFP) expression com- pared to the parental strain SJ4005 (see Fig. S1A in the ...
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The Human Cytomegalovirus Nonstructural Glycoprotein UL148 Reorganizes the Endoplasmic Reticulum
... an endoplasmic reticulum (ER)- resident glycoprotein, UL148, which activates the unfolded protein response (UPR) but is fully dispensable for viral replication in cultured ...prominent ...
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Original Article ASK1 induces retinal microvascular endothelial cell apoptosis through ER stress-associated pathway
... the endoplasmic reticulum (ER) stress-associated apoptosis pathway in microvascular endothelial ...an ER stress-dependent ...of ER stress-related proteins that are the master regulators ...
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