ER(+) Tumors
Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... that ER- cancers can emerge over time after exposure to tamoxifen. ER+ primary tumors may recur as ER- metastases in up to 20% of cases ...with ER+ or progesterone receptor posi- tive ...
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PubMedCentral-PMC4876991.pdf
... (ER−) tumors associated with an aggres- sive pathology and poor prognosis (13), we aimed to investi- gate whether cigarette smoking is related to increased risk in these subgroups of breast cancer in ...
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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen receptor (ER) levels and activity in ER+ breast cancer
... breast tumors show mutation or loss of PTEN or both, amplification and activating mutations in PIK3CA, amplification of Akt2 and p70S6kinase, and overexpression of Akt3 ...low ER and PR and poor outcome ...
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Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype.
... by ER/PR or HER2, separately, we observed no clear differences in the associations of aspirin use with breast cancer characterized by combinations of ER, PR, and HER2 (Table ...B tumors and a large ...
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Mechanisms for estrogen receptor expression in human cancer
... ERα has also been shown to modulate gene transcrip- tion through heterodimerizing with other transcription factors such as activating protein 1 (AP1) and nuclear factor kappa-light-chain-enhancer of activated B cells ...
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Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS)
... for ER, 36% to 54% for PR, and 3% to 22% for HER2 in both retrospec- tive series [6,10-14] and small prospective series ...for ER, PR, and HER2 (with fluorescence in situ hybridization [FISH] testing of ...
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Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients
... We also examined AGR2 mRNA levels under the same parameters and found almost similar association between AGR2 gene expression and clinicopathological variables as seen for AGR3 (Table S1). In line with these ...
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<p>Strategies for Increasing the Effectiveness of Aromatase Inhibitors in Locally Advanced Breast Cancer: An Evidence-Based Review on Current Options</p>
... The phase-2 LORELEI trial evaluated the ef fi cacy of letrozole plus taselisib or placebo in patients with operable ER+ HER2-negative BC, stage I-III. 334 patients were randomized to receive letrozole continuously ...
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Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma
... in tumors is associated with local immune checkpoint activation (ICA) and response to ...and tumors were stratified into 3 groups based on their expression ...ccRCC tumors showed increased immune ...
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Breast cancer in women using digoxin: tumor characteristics and relapse risk
... with ER-positive rather than ER-negative cancers, given that digoxin likely exerts its effect via attachment to the ER ...with ER-positive tumors and might affect an impact from ...with ...
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Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
... The Citizen Science Alliance (http://www.citizensciencealliance. org) is a collaboration of scientists, software developers and educa- tors, who use the concept of crowdsourcing to develop, manage and utilize ...
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Effect of obesity on molecular characteristics of invasive breast tumors: gene expression analysis in a large cohort of female patients
... of ER status ...late-stage tumors not stratified by subtype or ER status, in combination with confounding gene ex- pression results attributable to genetic ancestry, may have affected the ability to ...
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Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer
... The Citizen Science Alliance (http://www.citizensciencealliance. org) is a collaboration of scientists, software developers and educa- tors, who use the concept of crowdsourcing to develop, manage and utilize ...
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Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer.
... breast tumors and a role in breast tumor ...breast tumors showed that in 82% of ER+, 67% of Her2 overexpressing and 24% of triple-negative breast tumors both PDEF and CEACAM6 expression was ...
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Breast cancer receptor status and stage at diagnosis in over 1,200 consecutive public hospital patients in Soweto, South Africa: a case series
... (ERN) tumors range from 30% to 40% [3-5] to >70% [6-9]; in comparison, correspond- ing percentages in the United States are 35% in breast cancer patients aged 40 and decline to 15% to 20% by age 70, and are ...
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<p>Prevalence of ESR1 Mutation in Chinese ER-Positive Breast Cancer</p>
... of ER- positive breast cancers, 13 ESR1 mutations in Chinese patients have been rarely ...in ER- positive breast cancers in Chinese ...on tumors or blood samples of 340 ER- positive PBC and ...
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Expression profiling with RNA from formalin-fixed, paraffin-embedded material
... putative reference genes were selected from the literature [14] and from microarray results [15]. Expression was measured from intact and FFPE-derived RNA and raw Cts from all the 14 tumors are plotted for each ...
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Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers
... breast tumors and reduction mammoplasty tissue Paralemmin-1 mRNA levels were assessed in frozen breast cancer tumor tissue from 26 cases and in 10 re- duction mammoplasty ...with ER status in ...in ...
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Estrogen promotes estrogen receptor negative BRCA1 deficient tumor initiation and progression
... of ER-negative breast CSCs through para- crine signaling produced in ER-positive cells in response to estrogen [7, ...-deficient, ER-negative breast cancers [3, ...MGKO tumors with elevated ...
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Gene expression profiling and histopathological characterization of triple negative/basal like breast carcinomas
... the tumors were all ER-negative, 21% of the patients were treated with ...to ER-positive patients only; these guidelines have changed since the patients in this study were ...97 tumors. The ...
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