ERG and Cancer
Overexpression of truncated ERG from <em>TMPRSS2-ERG</em> fusion and prostate cancer development
... prostate cancer is one of the most common cancers worldwide and the second leading cause of death among all cancer types in Europe and North America, with the numbers of those affected continuing to ...
9
The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer
... that ERG undergoes ubiquitination and then is deubiquitinated by USP9X in prostate cancer cells to prevent its proteasomal ...full-length ERG, and it also binds the N-terminally truncated variants of ...
11
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer
... II ERG splice variants and C-MYC in LCM selected prostate cancer ...II ERG ratio in relation to C-MYC and PCA3 gene expression levels through Spearman’s correlation ...II ERG ratios across ...
12
TMPRSS2-ERG fusion promotes prostate cancer metastases in bone
... prostate cancer cell lines In order to assess the role of TMPRSS2-ERG fusion in PCa development, we generated cell lines stably overexpressing the fusion using retroviral translocation from luciferase ...
15
Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells
... prostate cancer (PC) patients because of chromosomal translocations or deletions involving the TMPRSS2 gene promoter and the ERG gene coding ...androgen-dependent ERG transcription factor expression ...
10
Predictive significance of TMRPSS2-ERG fusion in prostate cancer: a meta-analysis
... prostate cancer-specific death; j funnel plot for the analysis of biochemical recurrence; k funnel plot for the analysis of potential publication bias of tumor-specific ...
12
A Prospective Investigation of PTEN Loss and ERG Expression in Lethal Prostate Cancer
... by ERG expression with lethal prostate cancer among men diagnosed with prostate cancer between 1983 and 2009 in the Health Professional Follow-up Study and the Physicians’ Health ...
10
ERG induces androgen receptor mediated regulation of SOX9 in prostate cancer
... Farber Cancer Institute and Harvard School of Public Health, Boston, Massachusetts, ...with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression of ERG, an ETS transcription ...
15
Detection of TMPRSS2 : ERG fusion gene in circulating prostate cancer cells
... Long distance tumor metastasis is caused by tumor cell migration from the primary site into the blood stream, culminating in survival and re-establishment at a new site. It has been known for 150 years that tumor cells ...
7
Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer
... comparing ERG high to ERG low samples, suggesting an increased cancer aggressiveness of ERG high compared to ERG low ...between ERG high and ERG low were more pronounced ...
15
Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer
... targeting ERG affect PCa cell biology via down-regulation of Wnt/β-catenin signaling Over-expression of ERG in PCa is associated with disease initiation, progression and spread 4 ...This ERG ...
33
TMPRSS2:ERG gene aberrations may provide insight into pT stage in prostate cancer
... prostate cancer Slovenian patients who underwent laparoscopic radical ...non- ERG translocation) and ERG split (an ERG translocation without involvement of TMPRSS2 ...and ERG split in 8 ...
6
Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2
... Here, using three AR-negative PC3c cell clones with different TMPRSS2:ERG expression levels, we demonstrated that ectopic expression of TMPRSS2:ERG can induce, in a dose- dependent manner, PC3c cell ...
59
Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods
... of ERG oncoprotein in cells from multiple sample types including tissue and urine ...prostate cancer cells are present in urine/post-DRE urine samples of patients, due to manual manipulation of the ...
14
Original Article The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer
... and ERG overexpression is considered as a novel diagnostic marker for prostate ...ovarian cancer. The purpose of this study was to test ERG expression in ovarian cancer and its potential as a ...
7
Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1
... in ERG-associated CaP ...distinguish ERG-positive tumors from ERG- negative tumors, we find miR-449a is highly suppressed in ERG-positive ...by ERG in ERG- associated ...the ...
16
TMPRSS2â ERG gene fusion is rare compared to PTEN deletions in stage T1a prostate cancer
... population. ERG is a member of the ETS family, which has 28 unique ...FLI, ERG, ETV1 and ETV4 are commonly deregulated in ...and ERG are located within 3 megabases of each other on chromosome 21, and ...
20
The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells
... accelerates cancer by allowing the PI3K/AKT pathway to be constitutively switched on, promoting epithelial-mesenchymal transition (EMT) and metastasis ...prostate cancer (but not in all ...metastatic ...
6
Deletion of 3p13 is a late event linked to progression of <em>TMPRSS2:ERG</em> fusion prostate cancer
... all cancer cells, whereas events occurring at later stages of tumor progression will be detectable only in a sub- set of cancer ...prostate cancer heterogeneity tissue microarray (TMA) ...prostate ...
9
Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status.
... A subgroup of 552 cases genotyped as part of the iCOGS dataset was somatically phenotyped for the TMPRSS2:ERG gene fusion with a mean TMPRSS2:ERG positive frequency of 54% (range 44 - 60%) across the study ...
36