ERK and p38 MAPK
Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer
... The MAPK signaling pathways are important signaling cascades downstream of ROS that are involved in tumor migration and invasion ...the p38 MAPK pathway and cell invasion in ovarian cancer ...the ...
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Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK
... vates ERK and p38 MAPK in primary astrocytes (see [21] and this ...that p38, but not ERK, mediated the upregulation of Nrf2 and HO-1 by andrographolide, while in endothelial cells, ...
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Role of Regulatory Elements and the MAPK/ERK or p38 MAPK Pathways for Activation of Human Cytomegalovirus Gene Expression
... The MAPK signal transduction cascade consists of a three-component module consisting of MAPK, MAPK ki- nase (MEK, MAPKK, or MKK), and MAPK kinase kinase (MEKK, MAPKKK, or MKKK), which is ...
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Original Article Response gene to complement-32 mediates TGF-β-induced epithelial-mesenchymal transition via Erk-/p38-MAPK signaling pathways in human pancreatic cancer cell line BxPC-3
... Western blot assay was performed as descri- bed previously [7]. Briefly, Total proteins were extracted from BxPC-3 cells using EpiQuik Total Histone Extraction Kit (Epigentek, Farmingdale, NY, USA). The protein was ...
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12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... of ERK and p38 MAPK, Ras activation, cAMP response element-binding protein (CREB) phos- phorylation, DNA-binding activity, and transactivation, overexpression of intercellular adhesion molecule-1, ...
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ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... JNK/ ERK/p38 MAPK phosphorylation, and PARP cleavage in cultured primary ...not ERK inhibitor (U0126) or p38 MAPK inhibitor (SB203580), significantly reduced ZnO NP-induced ...
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Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK) phosphorylation in renal and vascular dysfunction
... phosphorylated p38- MAPK and ERK protein expressions of thoracic aorta, kid- ney cortex and kidney medulla were determined using standard SDS-PAGE and immunoblot ...
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Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP
... of p38 MAPk inhibition on neutrophil responses after stimulation with FMLP or ...inhibit p38 MAPk activity with negli- gible effect on other MAP kinase members, MEK1, or c-Raf ...
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Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart
... the p38-MAPKs. The third subfamily, p38-MAPK, is activated by various forms of environmental stress, including hyperosmolarity and heat shock (for a review, see Bogoyevitch, 2000; Kyriakis and ...
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Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans
... by MAPK inhibition (31), suggesting that activated MAPKs could play a role in the Pro33 regulation of ...of MAPK signaling in the enhancement of SERT activity by incubating SERT/Leu33 and SERT/Pro33 cells ...
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Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase
... Phosphorylation of p38 MAPK (Thr180/Tyr182) and ERK-1,2 (Thr202/Tyr204) was assayed using corre- sponding cell-base ELISA kits (R&D Systems). Confluent HUVECs grown on a 96-well cell culture ...
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Toll-Like Receptor 4-Mediated Activation of p38 Mitogen-Activated Protein Kinase Is a Determinant of Respiratory Virus Entry and Tropism
... of p38 mitogen-activated protein kinase (MAPK) signaling was able to significantly inhibit replication by all viruses ...virus-mediated p38 and extracellular signal-regulated kinase (ERK) ...
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Murine Coronavirus Replication-Induced p38 Mitogen-Activated Protein Kinase Activation Promotes Interleukin-6 Production and Virus Replication in Cultured Cells
... MAPKs, p38 MAPK and c-Jun N-terminal kinase (JNK), but not of extracellular signal-regulated kinase ...both p38 MAPK and JNK, which indicated that the MHV-induced stress-kinase activation was ...
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Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression
... GAPDH, ERK MAPK rabbit mAb, phospho-ERK MAPK rabbit mAb, p38 MAPK rabbit mAb, and phospho-p38 MAPK rabbit mAb overnight at 4 ° C, and incubated with horseradish ...
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LL202 protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting MAPK/AP-1 signaling
... inhibiting ERK/JNK/p38 MAPK pathways and the nuclear translocation of ...inhibiting MAPK/AP-1 signaling, which suggested that LL202 might be a potential effective drug for the treatment of ...
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Dual roles of extracellular signal-regulated kinase (ERK) in quinoline compound BPIQ-induced apoptosis and anti-migration of human non-small cell lung cancer cells
... of MAPK, JNK, p38 and ERK. Among MAPK members, JNK and p38 are activated in response to various intrin- sic and extrinsic stresses [21, ...activated p38 MAPK may induce ...
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“Docking Studies on Eupalitin-3-O-β-D-galactopyranoside as Potential Inhibitor of Cyprinus carpio (KOI CARP) MAPK/ERK Kinase 2 and Mitogen-Activated Protein Kinase (p38)” by Kader Asen Fathima, Chetancherry Somasundaram Parameswari, India.
... and p38 MAPKinase in TNF-α signalling was ...of MAPK in inflammation makes them attractive targets for advanced therapies and recent research is progressing to identify more selective inhibitors for ...
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Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
... of p38 MAPK induced by ATO, and this activity was partially dependent on AMPK ...of p38 MAPK by SB203580 or specific short interfering RNA (siRNA) promoted the inactivation of mTORC1 in ICC ...
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HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism
... with p38 MAPK to form a complex in ...the p38 MAPK pathway was ...and p38 MAPK may exist, as predicted previously based on affinity purification mass spectrometry (AP-MS) ...and ...
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Extracellular pH changes activate the p38 MAPK signalling pathway in the amphibian heart
... 2001). p38-MAPK is activated by dual phosphorylation at the Thr and Tyr residues of the Thr-Gly- Tyr motif which lies at the activation loop of the molecule (Davis, ...The p38-MAPK activation ...
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