ERK signaling pathway
Berberine inhibits enterovirus 71 replication by downregulating the MEK/ERK signaling pathway and autophagy
... (EGFR) signaling pathways which can be activated by several stimulus including EV71 infection in various cell types [6, ...MEK/ERK signaling pathway by U0126 or specific siRNAs has been found ...
8
Original Article Folate receptor alpha promotes endometrial carcinoma cell proliferation and inhibits apoptosis by regulating the ERK signaling pathway
... and ERK activity is the ...with ERK activity, were higher following EC cell line differentiation ...affecting ERK activity and survivin ...enhancing ERK signaling pathway ...
8
<p>CCNY Accelerates Cylcin E Expression to Regulate the Proliferation of Laryngeal Carcinoma Cells via MEK/ERK Signaling Pathway</p>
... In this study, the function of CCNY was explored in Hep2 cells. It indicated cell growth was controlled by the expres- sion of CCNY. Further research illustrated that the G1/S phase transition was regulated by CCNY. We ...
10
Original Article Huosha Oral Solution improves symptoms of irritable bowel syndrome with diarrhea by inhibiting activation of ERK signaling pathway and apoptosis of interstitial cells of Cajal in rats
... of ERK signaling pathway ...the ERK pathway was ...the ERK pathway was inhibited, and the expression of the apoptosis-promoting factor cleaved cas- pase-3 was also ...
11
Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway
... To explore the potential mechanism by which pectolinarigenin induced HCC cell proliferation, we conducted Western blot to investigate the potential molecular targets of pectolinari- genin. The results indicated that ...
10
A Raf/MEK/ERK signaling pathway is required for development of the sea urchin embryo micromere lineage through phosphorylation of the transcription factor Ets
... Ras>Raf>MEK>MAP-kinase signaling is thought to stimulate the transcriptional activation function of this class of Ets family members by an unknown ...Raf/MEK/ERK signaling pathway in ...
14
Original Article Trichostatin A promotes bladder cancer cell apoptosis and inhibits cell autophagy through MEK/ERK signaling pathway
... Abstract: Histone acetylation enzyme inhibitor is a kind of high-efficiency and low toxicity drug for cancer. Therefore, as histone acetylation enzyme inhibitor, it is very important to explore the mechanism of ...
10
LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway
... activated ERK was transferred to the nucleus to regulate the activity of transcription fac- tors and produce cellular ...the ERK family, including ...[17]. ERK sig- naling pathway is involved ...
21
Antidepressant like effects of acupuncture involved the ERK signaling pathway in rats
... Methods: Eighty male Sprague – Dawley rats were randomly divided into eight groups: control group, model group, model + Acupuncture group (Acu group), model + fluoxetine group (FLX group), model + DMSO group (DMSO ...
11
CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
... Accumulating evidence suggests that the carboxyl termini of CLDNs, which are located in the cytoplasm, participate in signal transduction through their PDZ (PSD-95/Dlg/ZO-1 homology domain)-binding domains, which bind to ...
12
<p>EGCG overcomes gefitinib resistance by inhibiting autophagy and augmenting cell death through targeting ERK phosphorylation in NSCLC</p>
... the ERK signaling pathway also has a critical role in cell proliferation, tumorigen- esis, cell cycle arrest and drug-acquired ...12 ERK is activated via a pathway that involves GTP ...
11
Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
... Ras-ERK signaling pathway are limited due to adaptive resistance of tumor ...Ras-ERK pathway can result in activation of the PI3K-AKT pathway, thereby diminishing the therapeutic ...
22
CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway
... (PI3K)/Akt pathway contributes to regulate the activity of SREBPs at the transcriptional and posttranslational levels (18, ...MEK/ERK signaling pathway is critical for 2A-induced SREBP1a ...
15
Downregulated miR-98-5p promotes PDAC proliferation and metastasis by reversely regulating MAP4K4
... MAPK/ERK signaling pathway through downregulation of ...MAPK/ERK signaling, thus, highlighting the potential of miR-98-5p as a therapeutic target for ...
14
Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways
... associated signaling to regulate melaogenesis via manip- ulating a -MSH-induced ...MAPK/ ERK signaling pathway-associated molecules was further ...
11
A novel mutation of MSX1 in oligodontia inhibits odontogenesis of dental pulp stem cells via the ERK pathway
... vector. The increased expression of DSPP and BSP in- duced by wild-type MSX1 transfection also was attenu- ated after the inhibition of the ERK signaling pathway (Fig. 5e, f ). Furthermore, we ...
10
EGF signaling regulates the proliferation of intestinal stem cells in Drosophila
... PVR/p38 signaling (Biteau et ...this signaling network has to be ...and ERK regulate FOS activity directly by phosphorylation on distinct residues, controlling ISC proliferation in a combinatorial ...
11
Original Article HSP70 inhibitor VER155008 suppresses pheochromocytoma cell and xenograft growth by inhibition of PI3K/AKT/mTOR and MEK/ERK pathways
... ity, function, and stability of more than 200 known proteins [9, 10]. Recently, some re- searchers have focused on the 70 kDa heat shock protein, HSP70-one member of the HSP family-because overexpression of HSP70 fre- ...
10
PubMedCentral-PMC5566864.pdf
... of ERK-deficient ...of ERK-mediated phosphorylation of metabotropic or ionotropic receptors or voltage gated ion channels (Sweatt, ...example, ERK phosphorylation regulates dendritic localiza- tion ...
14
Phosphorylation of Beta 3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
... insulin signaling in white adipose tissue but not liver (Supplemental Figs 3F and 3G) These data suggest that modest improvement in adipose tissue insulin sensitivity was not suf fi cient to perturb whole body ...
14