Estrogen receptor
Investigation of variants in estrogen receptor genes and perinatal depression
... childbirth. Estrogen levels fluctuate greatly during the course of pregnancy and may contribute to mood ...two estrogen receptor genes might contribute to the genetic susceptibility to ...
7
Mechanisms for estrogen receptor expression in human cancer
... However, estrogen also promotes mammary, ovarian and endometrial tumorigen- ...esis. Estrogen antagonists and drugs that reduce estrogen biosynthesis have become highly successful therapeutic agents ...
11
Estrogen and inflammation modulate estrogen receptor alpha expression in specific tissues of the temporomandibular joint
... of estrogen in the human female, having biological effects through binding the estrogen receptor alpha (ERα) and beta (ERβ) ...the estrogen receptors ERα and ERβ in the thymus [14,15], bone ...
8
The Role of Estrogen Receptor β in Prostate Cancer
... In the adult human prostate, ERβ is characterized as an important mediator of epithelial differentiation (37). The mechanisms through which ERβ main- tain differentiation involve the degrada- tion of hypoxia-inducible ...
8
Estrogen Receptor Status in Upper Gastrointestinal Malignancies
... examining estrogen receptor protein, the molecular hybridization in examining estrogen receptor mRNA has a higher sensitivity (41,42) and estrogen receptor mRNA expression has ...
75
Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor (ER), now referred to as selective estrogen receptor modulators (SERMs), can demonstrate remarkable differences in activity in the various estrogen target tissues, ...
10
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators
... Women at high risk for breast cancer and OVCA, hav- ing a mutation in either BRCA1 or BRCA2 genes, may prophylactically take selective estrogen receptor modula- tors (SERMs), such as 4-hydroxytamoxifen ...
13
Src promotes estrogen dependent estrogen receptor α proteolysis in human breast cancer
... Estrogen drives both transcriptional activation and proteolysis of estrogen receptor a (ERa; encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 ERa-negative and 50 ...
12
Estrogen and estrogen receptor alpha promotes malignancy and osteoblastic tumorigenesis in prostate cancer
... of estrogen and ERα in prostate cancer ...that estrogen had an oncogenic effect on prostate cancer cells by increasing cell migration and anchorage-independent ...of estrogen suggesting that the ...
15
Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?
... of estrogen receptor (ER)-dependent cellular proliferation signaling is well established in breast cancer pathogenesis; however, very little is known about the clinical relevance of ER-independent ...and ...
7
Transactivation of the estrogen receptor promoter by BRCA1
... Background: Absence of the estrogen receptor-α (ER) is perhaps the most distinctive pathological feature of breast cancers arising in women who inherit a mutation in BRCA1. Two hypotheses, not necessarily ...
8
Estrogen rescues heart failure through estrogen receptor Beta activation
... [5]. Estrogen mainly acts through classical estrogen receptor alpha (ER α ) and/or estrogen receptor beta (ER β ), and both receptors are present in the heart [7, ...
11
Suppression of the inflammatory response in experimental arthritis is mediated via estrogen receptor α but not estrogen receptor β
... Figure 2 ERA-63 inhibits the tetanus-specific delayed type hyper- sensitivity response in WT and ERβKO but not in the ERαKO mice. Mice were ovariectomized at day -14. Mice (n = 8 per group) were oral- ly treated daily ...
12
Clinicopathological Correlation of Estrogen Receptor Alpha Gene Polymorphism and Estrogen Receptor Status in Breast Cancer - A Study.
... OF ESTROGEN RECEPTOR ALPHA GENE POLYMORPHISM AND ESTROGEN RECEPTOR STATUS IN BREAST CANCER- A STUDY OF 153 CASES” is the original and bonafide work done by ...
133
Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.
... the estrogen receptor (ER) signaling pathway occurs in over 70% of breast cancers ...factor receptor signaling, especially of the EGFR/HER2 pathway, as important mechanisms of de novo or acquired ...
10
Estrogen receptor mutations and their role in breast cancer progression
... The estrogen receptor (ER) belongs to a family of nu- clear hormone receptors that act as ligand-activated transcription factors ...the receptor, which translo- cates to the nucleus, binds as a ...
8
DOCKING STUDIES OF SUBSTITUTED CHROMAN ANALOGS AT ESTROGEN RECEPTOR
... Estrogen receptor (ER) is found to be overexpressed in more than 60% cases of human breast cancers [3]. Designing drug-like molecules that can fit to the alpha ligand-binding domain of ER will be a ...
5
Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease
... TAM (1 M) inhibits HCV replication by interfering with the association of estrogen receptor alpha with RNA-dependent RNA polymerase NS5B (34). As a result, TAM interferes with the formation of the ...
10
Crosstalk of TTC5 cofactor and the estrogen receptor in breast cancer
... of estrogen to ...selective estrogen receptor modulators (SERMs) (Riggs and Hartmann, 2003; Cuzick et ...of estrogen in tissues like bone, cardiovascular system and brain, while antagonizing ...
188
Role of estrogen in lung cancer based on the estrogen receptor-epithelial mesenchymal transduction signaling pathways
... group, estrogen group, and estrogen plus tamoxifen ...of estrogen receptor α (ERα), estrogen receptor β (ERβ), phosphatidylinositol 3′-kinase (PI3K), AKT, E-cadherin, and ...
15