Estrogen receptor alpha (ERα)
Estrogen receptor alpha (ERα/ESR1) mediates the p53- independent overexpression of MDM4/MDMX and MDM2 in human breast cancer
... characterized Estrogen Receptor Alpha (ERα/ESR1) as a regulator of MDM2 expression and an MDM2- and p53-interacting ...between ERα and MDM4 has not been ...between ERα status and ...
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The role of total and cartilage specific estrogen receptor alpha expression for the ameliorating effect of estrogen treatment on arthritis
... [22]. Estrogen affects T lympho- poiesis, and we and others have previously demonstrated that estrogenic repression of T lymphopoiesis is mediated via ERα ...[27,34]. Estrogen has also been shown to ...
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Molecular Docking, 3D Structure-Based Pharmacophore Modeling, and ADME Prediction of Alpha Mangostin and Its Derivatives against Estrogen Receptor Alpha
... trogen receptor α (ERα) using computational simulation approaches to ob- tain new potent of anti-breast ...against estrogen receptor α (ERα) (PDB ID: ...
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer
... the estrogen receptor regulates transcription Although the DNA binding domains of ERα and ERβ are nearly identical, there is considerable documentation that these receptor subtypes differ ...
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Utility of estrogen receptor alpha (ERα), progesterone receptor (PR), and her2 expression in primary breast carcinoma in Iraqi Women
... hormone receptor and HER2 status at the time of initial diagnosis has been established as a clinically useful, standard- of-care parameter in determining treatment options and subsequent patient response ...
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Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization
... of ERα can be blocked by the ERα antagonist 4-hydroxy tamoxifen ...in ERα sub-cellular localization when the cells were treated with 4-OHT in combination with HRG and/or E2 (Figure 4A and 4B), which ...
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Immune response in breast cancer brain metastases and their microenvironment: the role of the PD 1/PD L axis
... for estrogen receptor alpha (ERα), progesterone receptor (PR) and HER2 was determined in the central laboratory by two pathologists (RP and WB) who were blinded to the original ...
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Original Article Expression of PGRMC1 in paraffin-embedded tissues of breast cancer
... progesterone receptor membrane component 1 (PGRMC1) expression may explain this ...of estrogen receptor alpha (ERα), progestrone receptor (PR), Ki67 and PGRMC1 by ...
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The origins of estrogen receptor alpha positive and estrogen receptor alpha negative human breast cancer
... classical estrogen-induced mitogenic ...to estrogen [19–21], including estrogen-induced growth, they continued to express ER, suggesting that these pathways may only be partially involved in the ...
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Gene expression signature of atypical breast hyperplasia and regulation by SFRP1
... for estrogen receptor alpha (ER α +) and approximately 90% of tumors that develop subsequently are ...low-grade ERα-positive tumors. Selective receptor modulators or aromatase ...
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Chromatin immunoprecipitation assay detects er recruitment to gene specific promoters in uterus
... examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERα), a ligand-activated transcription factor, to uterine gene promoters in ...
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A review on the anti-carcinogenic and anti-metastatic effects of flax seed lignan secolariciresinol diglucoside (SDG)
... endogenous estrogen metabolites for human estrogen receptor alpha and beta subtypes: Insights into the structural determinants favoring a differential subtype ...
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The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I SPY 2 randomized neoadjuvant setting
... : Estrogen receptor alpha; EU FP7: European Union 7th Framework Programme; FF: Fresh frozen; HER2: Human epidermal growth factor receptor 2; HR: Hormone receptor status; HRD: Homologous ...
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Receptor conversion in distant breast cancer metastases
... study receptor conversion for estrogen receptor alpha (ERa), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) in a large group of distant ...
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Estrogen receptor α (ERα) mediates 17β-estradiol (E2)-activated expression of HBO1
... to estrogen is reported to be asso- ciated with women’s risk for breast cancer and the biological actions of estrogens are mediated primarily by ER a which belongs to the nuclear receptor superfamily, a ...
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<p>ERRα is an aggressive factor in lung adenocarcinoma indicating poor prognostic outcomes</p>
... gen receptor α (ER α ) as a probe, ERR α was fi rst screened by Giguere et ...the estrogen receptor signaling system but also participates in many metabolic processes such as glucose metabolism, lipid ...
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... reseptor estrogen β ,di mana genotip GT dan TT (wild type-mutan dan mutan) lebih banyak terdapat pada kelompok kasus yaitu 24 kasus (60%) dan 5 kasus (12,5%), sedangkan pada kelompok kontrol, yang terbanyak adalah ...
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Dietary grape polyphenol resveratrol increases mammary tumor growth and metastasis in immunocompromised mice
... for estrogen and low concentrations of resveratrol in breast cancer cell mi- gration, extension of actin structures that promote cell migration, and the activity of Rac, a key signaling pro- tein that promotes the ...
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Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain
... the receptor phenotype of brain metas- tases does not reflect its status in primary ...of receptor gain, may deny some patients a poten- tially effective systemic ...
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Chinese herb mix Tiáo Gēng Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats
... controversial [29-32]. In our study, expression of ERs decreased in the hypothalamus of ovariectomized rats and increased upon treatment with TG-decoction. Simi- lar results have been recently reported by Wu et al. [33] ...
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