eukaryotic elongation factor 2
FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells
... Eukaryotic elongation factor 2 kinase (eEF2K), an emerging molecular target for cancer therapy, contributes to cancer proliferation, cell survival, tumorigenesis, and invasion, disease ...
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Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
... The eukaryotic elongation factor-2 kinase (eEF2K) mediates critical regulation of dendritic mRNA translation and is a crucial molecule in diverse forms of synaptic ...
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Everolimus enhances cellular cytotoxicity of lapatinib via the eukaryotic elongation factor-2 kinase pathway in nasopharyngeal carcinoma cells
... Methods: The Cell Counting Kit 8 and colony formation assay were used to detect the effect of lapatinib alone or lapatinib combined with everolimus on the growth and proliferation of cells. Apoptosis was tested by flow ...
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Elevated eukaryotic elongation factor 2 expression is involved in proliferation and invasion of lung squamous cell carcinoma
... Eukaryotic elongation factor 2 (EF2), is a critical enzyme solely responsible for catalyzing the translocation of the elongated peptidyl-tRNA from the A to P sites of the ribosome during the ...
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Eukaryotic elongation factor 2 controls TNF α translation in LPS induced hepatitis
... protein elongation during translation, which would allow rapid cell adaptation to physiological ...translational elongation is poorly ...the elongation of nascent TNF-a protein in ...of ...
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The cytotoxic effect of diphtheria toxin on the actin cytoskeleton
... Abstract: Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic ...
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Binding of the eukaryotic translation elongation factor 1A with the 5’UTR of HIV 1 genomic RNA is important for reverse transcription
... at 2 h ...at 2 h of post-infection, were similar indicating that reduced levels of eEF1A-RTC asso- ciation in mutated virus infection were not due to differ- ences in viral entry ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... (Figure 2) and Gcn2p (Dever et ...ing elongation factor eEF1A (previously eEF1␣), were pass eIF2B in vivo ...demonstrated factor, eEF1B, when provided on a low-copy-number recently that eIF2␣ ...
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Eukaryotic Elongation Factor 1A Interacts with the Upstream Pseudoknot Domain in the 3′ Untranslated Region of Tobacco Mosaic Virus RNA
... Deletion of the conserved A residue that creates a bulge in stem 2 of PK3 (RNA-14) had no effect on binding of eEF1A. We next turned our attention to the role of the PK loop sequences in the eEF1A interaction. ...
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Eukaryotic Elongation Factor 1δ Is Hyperphosphorylated by the Protein Kinase Encoded by the UL13 Gene of Herpes Simplex Virus 1
... (iii) Viruses have evolved a variety of mechanisms to mod- ulate the host cell translational apparatus to aid in their rep- lication. In most cases reported so far, viruses have targeted proteins designed to maintain the ...
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Conserved Protein Kinases Encoded by Herpesviruses and Cellular Protein Kinase cdc2 Target the Same Phosphorylation Site in Eukaryotic Elongation Factor 1δ
... In the third series of experiments, we mutagenized pME- EF-1␦(F) by replacing with alanines the serine codons at po- sitions 118 and 119 (Ser-118/119) or the single serine codon at position 133 (Ser-133) (Fig. 2B) and ...
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MicroRNA-33a-5p Modulates Japanese Encephalitis Virus Replication by Targeting Eukaryotic Translation Elongation Factor 1A1
... to GTP and transfers the aminoacylated-tRNAs to the A site of ribosome during translation elongation. In addition, Recent stud- ies also identified the crucial role of EEF1A1 in infections of sev- eral viruses ...
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Cutaneous Human Papillomavirus Type 38 E7 Regulates Actin Cytoskeleton Structure for Increasing Cell Proliferation through CK2 and the Eukaryotic Elongation Factor 1A
... kinase 2 is the upstream regulator of the MEK- ERK-Rho cascade that is activated by HPV38 E7 during actin stress fiber ...kinase 2 (CK2) is a ubiquitous and constitutively active Ser/Thr protein kinase that ...
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The eukaryotic translation elongation factor 1A regulation of actin stress fibers is important for infectious RSV production
... protein eukaryotic translation elongation factor 1A (eEF1A) is an actin binding protein that plays a role in the formation of filamentous actin (F-actin) ...cellular factor eEF1A plays an ...
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Purification and characterization of elongation factor 2 (EF2) and cyclic AMP-independent protein kinases from soybean (Glycine max, L) cotyledons.
... 60,000 - 112,000 (Merrick et al., 1975; Galasinski and Moldave, 1969; Collins et al., 1971; Twardowski and Legocki, 1973; Mizumoto et al., 1974; Comstock and Van, 1977). EF2 contains twenty two cysteine groups and the ...
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Structural Basis for EarP Mediated Arginine Glycosylation of Translation Elongation Factor EF P
... ranslation elongation is a nonuniform process and directly depends on the amino acids (aa) to be incorporated into the growing polypeptide chain ...the eukaryotic and archaeal elongation ...
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Identification of a crenarchaeal orthologue of Elf1: implications for chromatin and transcription in Archaea
... the eukaryotic RNAP subunit RPB8 ...the eukaryotic transcription elongation factor ...In eukaryotic chromatin, nucleosomes consist of the highly conserved histone proteins H2A, H2B, H3 ...
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Nanocapsule delivered Sleeping Beauty mediates therapeutic Factor VIII expression in liver sinusoidal endothelial cells of hemophilia A mice
... However, 2 previous SB-Tn gene therapy stud- ies have described the replacement of FVIII in liver via hydrody- namic delivery (54); and lung endothelial cells using linear poly- ethylenimine ...
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Overexpression of human virus surface glycoprotein precursors induces cytosolic unfolded protein response in Saccharomyces cerevisiae
... The eukaryotic translation elongation factor 1A (eEF1A, encoded by two identical yeast genes TEF1 and TEF2, also known as Tef2p) is localized in cell cytoplasm and has several important functions ...
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Maintenance of Transcription Translation Coupling by Elongation Factor P
... In our analysis, we utilized artificial constructs in which strong Rho-dependent or intrinsic termination signals were placed be- tween a PPPPPP motif and a reporter gene. While these model terminators enabled us to ...
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