eukaryotic initiation factor 4E binding protein
Frequent activation of EGFR in advanced chordomas
... AKT protein trans- duces signals to several effector molecules, including ...and eukaryotic initiation factor 4E- binding protein 1 ...
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PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability
... that eukaryotic initiation factor 4E-binding protein 1(4E-BP1) was highly regulated by ...that 4E-BP1 up-regulation correlates with increased PC-1 expression in ...
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Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... of protein synthesis, and ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in ...
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MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling
... 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein 1; AECs: Airway epithelial cells; AKT: Protein kinase B; CPE: Cytopathic effect; EC50: Half ...
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Effects of oral phosphatidic acid feeding with or without whey protein on muscle protein synthesis and anabolic signaling in rodent skeletal muscle
... hyper-phosphorylating eukaryotic initiation factor 4E (eIF4E)-binding proteins (4EBP-1/2); c) activated p70s6k phosphorylates and activates ribosomal protein s6 (rps6), while ...
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Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... of eukaryotic initiation fac- tor (eIF) 4E activity slows G1 progression in yeast [13] and non-transformed mammalian cells ...translation initiation and is thought to function through eIF4F, a ...
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Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... virus-encoded protein termed VPg via a tyrosine residue (39, ...NIa protein of tobacco etch potyvirus, a precursor form of VPg, has been found in the nucleus (10, 23, 46), and mutations in the VPg domain ...
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Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... stronger binding to RNAs protected by cap 4 than to RNAs protected by cap 2 (5, ...cytoplasmic protein that comigrates with polysomal fractions on sucrose ...translation factor, since in higher ...
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Taking aim at translation for tumor therapy
... cap binding protein eukaryotic translation initiation factor 4E (eIF4E), leading to enhanced translation of numerous tumor-promoting ...
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Eukaryotic initiation factor 4E 3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila
... cap- binding complexes, as previously reported for Drosophila eIF4G- 2 (Baker and Fuller, 2007; Franklin-Dumont et ...in protein synthesis during ...chaperone protein that is required for activation ...
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The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... Z protein associates with the promyelocytic leukemia protein PML and the ribosomal P ...Z protein is a small zinc-binding RING protein with an unknown function which is required for the ...
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Original Article Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis
... eIF4E, 4E-BP1 and their phosphorylated forms simul- taneously in the same normal, dysplastic and malignant colorectal ...the initiation and progression of CRC, their potential to serve as prognostic markers ...
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Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... other binding domains are, however, all missing from this ...this protein is a bona fide initiation factor performing the function of a scaffold in the translation initiation complex of ...
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Studying Hepatitis C Virus: Making the Best of a Bad Virus
... ture failed. Through the use of bioinformatics, chimpanzee infections, surrogate expression systems, and biochemical anal- ysis, the structure of the HCV genome, the polyprotein pro- cessing mechanisms, the ...
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<p>eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats</p>
... the protein expression of LC3B and p62 after transfection with eIF2 α siRNA was detected by Western ...the protein expression of LC3B was upregulated and the protein expression of p62 was ...
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Cowpea mosaic virus middle component RNA contains a sequence that allows internal binding of ribosomes and that requires eukaryotic initiation factor 4F for optimal translation.
... In vitro translation of both proteins directed by T7 transcripts of M-RNA was stimulated fourfold by eukaryotic initiation factor 4F eIF-4F, the cap-binding protein complex.. The ratio o[r] ...
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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... 19% binding; and CAT mRNA/CHX + FA: 37,655 cpm, 2% ...mRNA. Initiation factor preparations were cross-linked to [ 32 P]-cap-labeled mRNA in the absence (lane 2) ...
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CHARACTERIZATION OF EIF2Bε AND ITS INTERACTION WITH RGS2
... We found that RGS2 can bind to all of the different types of truncation mutants that we generated, thereby confirming the yeast two-hybrid data that RGS2 binding domain of eIF2Bε lies near the C-terminus. In ...
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Multiple isoelectric forms of poliovirus RNA-dependent RNA polymerase: evidence for phosphorylation.
... The host cell protein required for in vitro replication of poliovirus is a protein kinase that phosphorylates eukaryotic initiation factor 2.. ATP is required for initiation of polioviru[r] ...
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Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs
... muscle protein synthesis and how this changes with ...in protein degradation ...RING-finger protein-1 (MuRF1) and autophagy-lysosome systems, ...microtubule-associated protein light chain 3 ...
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