eukaryotic initiation factor 4E (isolated p25)
Original Article Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis
... translation initiation in the genesis and maintenance of multiple types of cancer is becoming ...the eukaryotic initiation factor 4E (eIF4E) which is the rate limiting component of the ...
10
The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... translation factor, eukaryotic initiation factor 4E (eIF-4E) in infected and transfected ...translation factor led us to investigate whether Z could modulate host cell ...
8
Binding Specificities and Potential Roles of Isoforms of Eukaryotic Initiation Factor 4E in Leishmania
... isoforms isolated from cells exposed to different conditions revealed that the level of LeishIF4E-1 was clearly higher in axenic amas- tigotes, as expected from the finding of an amastigote-specific element in its ...
11
Complex Formation between Potyvirus VPg and Translation Eukaryotic Initiation Factor 4E Correlates with Virus Infectivity
... to a virus-encoded protein termed VPg via a tyrosine residue (39, 40). VPg has several suggested roles in the virus life cycle. Interactions of VPg with the viral RNA polymerase in yeast (25, 33) and in vitro (15) ...
8
Eukaryotic initiation factor 4E 3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila
... the initiation step, different mechanisms have evolved to regulate eIF4E activity (Hernández et ...and 4E-HP (Cho et ...translation initiation, whereas the other isoforms might be involved in more ...
10
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia
... translation initiation appears a promising approach for cancer therapy, by using small molecule inhibitors of eIF4A or eIF4E:eIF4G interaction or using antisense oligo- nucleotides (ASOs) against eIF4E [17], the ...
12
Effects of leucine and its metabolite β hydroxy β methylbutyrate on human skeletal muscle protein metabolism
... 4EBP1, eukaryotic initiation factor 4E binding protein 1; α -KIC, α -ketoisocaproate; AA, amino acid; AKT, protein kinase B; APE, atom percent excess; BCAA, branched-chain amino acid; BCAT, ...
13
Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs
... modulate skeletal muscle protein synthesis and how this changes with development. In the current study, we identified mechanisms involved in protein degradation regulation. In experiment 1, 6- and 26-d-old pigs were ...
11
Effects of oral phosphatidic acid feeding with or without whey protein on muscle protein synthesis and anabolic signaling in rodent skeletal muscle
... hyper-phosphorylating eukaryotic initiation factor 4E (eIF4E)-binding proteins (4EBP-1/2); c) activated p70s6k phosphorylates and activates ribosomal protein s6 (rps6), while ...
11
PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stability
... that eukaryotic initiation factor 4E-binding protein 1(4E-BP1) was highly regulated by ...that 4E-BP1 up-regulation correlates with increased PC-1 expression in human prostate ...
14
Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma
... translation initiation is coupled with cell cycle progression and cell growth, whereas excessive ribosome biogenesis and translation initiation often lead to tumor transformation and ...of eukaryotic ...
14
Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
... As eukaryotic translation initiation factor 4E (eIF4E) cooperates with c-Myc during lymphomagenesis, induces drug resistance, and is a genetic modifier of the rapamycin response, we have ...
11
Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... and eukaryotic initiation factor (eIF) 4E-binding protein-1 (4E-BP1) phosphorylation in gastrocnemius and masseter muscles (P < ...and 4E-BP1 phosphorylation were completely ...
10
Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... By the knowledge from other eukaryotes, His37, Pro38, Val69, Trp73, Leu131, Glu132, and Leu135 in eIF4E (by hu- man eIF4E-1 numbering) are involved in interacting with the scaffold protein eIF4G and 4E-BPs (27). ...
12
Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... translation initiation have not yet been well es- tablished, and none of these proteins has been identified so ...translation initiation, which pro- ceeds in several steps and depends on at least 12 ...
6
Visualization of the Interaction between the Precursors of VPg, the Viral Protein Linked to the Genome of Turnip Mosaic Virus, and the Translation Eukaryotic Initiation Factor iso 4E In Planta
... Although positive-sense RNA viruses replicate in the cyto- plasm, there are several examples of proteins from such viruses that have been found in the nucleus, often in the nucleolus (for reviews, see references 23 and ...
8
Taking aim at translation for tumor therapy
... Increased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation ...
5
MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling
... 4E-BP1: Eukaryotic translation initiation factor 4E-binding protein 1; AECs: Airway epithelial cells; AKT: Protein kinase B; CPE: Cytopathic effect; EC50: Half maximal effective ...
19
Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways
... large initiation factor eIF4G, an interaction that is inhibited by association of eIF4E with the small 4E-binding proteins ...translation initiation factor 2 ␣ (eIF2 ␣ ) on serine 51 ...
13
Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... elongation factor eEF1A (previously eEF1␣), were pass eIF2B in vivo ...demonstrated factor, eEF1B, when provided on a low-copy-number recently that eIF2␣ is required to promote efficient in- ...
10