Eukaryotic translation: cap-dependent initiation
Cap-Independent Translation Conferred by the 5′ Leader of Tobacco Etch Virus Is Eukaryotic Initiation Factor 4G Dependent
... of cap-independent translation in ...enhance cap-independent translation in vivo but not in vitro (31), suggesting the possibility that a factor required for the function of the TEV leader ...
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Dengue Virus Utilizes a Novel Strategy for Translation Initiation When Cap-Dependent Translation Is Inhibited
... undergo translation in a cap-dependent ...and translation are not affected under conditions that inhibit cap-depen- dent translation by targeting the cap-binding protein ...
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Interaction of eukaryotic initiation factor eIF-4B with a picornavirus internal translation initiation site.
... the initiation factors involved in the cap-dependent translation initiation may also be used in the internal initiation would signify that picornaviruses have not developed a new ...
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The Eukaryotic Translation Initiation Factor 4GI Is Cleaved by Different Retroviral Proteases
... inhibit cap-dependent translation through cleav- age of the translation initiation factor eIF4G without affecting IRES-driven translation with mRNAs having the 5⬘ leader of ...
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Cap dependent translation contributes to resistance of myeloma cells to bortezomib
... the eukaryotic translation initiation factor 4F (eIF4F) complex on the 5' m7 GpppN cap structure of ...the cap binding protein eIF4E , the scaffold protein eIF4G and the ATP- ...
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Recent insights into eukaryotic translation initiation factors 5A1 and 5A2 and their roles in human health and disease
... Several eukaryotic translation initiation factors were sug- gested as a host cell cofactor for viruses replication and propagation, including ...RNA translation and cap-dependent ...
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Eukaryotic Translation Initiation Factor 4 Gamma 1 (EIF4G1): a target for cancer therapeutic intervention?
... the cap-dependent translation, however, EIF4G2 isoform is involved in IRES-dependent transla- tion in cells [20, ...for cap- dependent ...start cap-depend- ent ...
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Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation
... inhibits translation, and it also induces a template-dependent endonucleolytic cleavage of host ...of cap-dependent and internal ribosome entry site (IRES)-driven mRNAs, including SARS ...
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Eukaryotic translation initiation factor 4All contributes to microRNA 122 regulation of hepatitis C virus replication
... UTR-driven translation could be allevi- ated by eIF4AI knockdown, as seen for HCV replication in Figure 4C, combined knockdown of eIF4AI and eIF4AII was carried out before transfection of Huh7 cells with 5 LUC3 ...
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The 3′ Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA
... interactions. To our surprise, mRNA featuring the 3 ⬘UTR sequence was translated at least as actively as that featuring the 3 ⬘ poly(A) tail [compare N-RNA–poly(A) with N-RNA– 3 ⬘UTR in Fig. 2D]. These observations ...
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Identification in the Ancient Protist Giardia lamblia of Two Eukaryotic Translation Initiation Factor 4E Homologues with Distinctive Functions
... Only eIF4E2 plays an essential function in protein synthesis in Giardia. To elucidate whether eIF4E1, eIF4E2, or both perform an essential function in Giardia, an antisense-ri- bozyme strategy with a viral vector, which ...
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Investigating the role of SUMOylation of eukaryotic translation initiation factors
... 4E-BP Family The eIF4E binding proteins (4E-BPs) are key regulators of protein synthesis. 1-3 As their name suggests, they function by interacting with eIF4E. This inhibits eIF4E function by prevent- ing it from ...
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Minimum Requirements for the Function of Eukaryotic Translation Initiation Factor 2
... nebusch 1994). These combined results suggested to in gene dosage requirements for IMT raises the possibil- us that gcd11-K250R strains might exhibit a reduced ity that eIF2B provides a function, in addition to nucleo- ...
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On the functions of the h subunit of eukaryotic initiation factor 3 in late stages of translation initiation
... comm en t re v ie w s re ports refer e e d re sear chdeposited research interacti o ns inf o rmation eif3h, one would expect elevated polysome loading in the mutant, exactly the opposite of what was observed. The effect ...
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The Cap-Binding Translation Initiation Factor, eIF4E, Binds a Pseudoknot in a Viral Cap-Independent Translation Element
... SUMMARY Eukaryotic initiation factor eIF4E performs a key early step in translation by specifically recognizing the m 7 GpppN cap structure at the 5 0 end of cellular ...0 cap and thus ...
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Collybistin and gephyrin are novel components of the eukaryotic translation initiation factor 3 complex
... local translation and synaptic plasti- city in dendrite ...synaptic translation and in the pathophysiology of diseases associated with mutations in these ...
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Insights into Eukaryotic Translation Initiation from Mass Spectrometry of Macromolecular Protein Assemblies
... Abstract Translation initiation in eukaryotes requires the interplay of at least 10 initiation factors that interact at the different steps of this phase of gene ...of initiation factors and ...
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Translation initiation events on structured eukaryotic mRNAs generate gene expression noise
... loop and a poly(G) motif, not only inhibit translation initiation when inserted into an mRNA 5 untranslated region, but also generate noise. The noise-enhancing effect of the stem–loop structure also ...
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The Lymphocytic Choriomeningitis Virus RING Protein Z Associates with Eukaryotic Initiation Factor 4E and Selectively Represses Translation in a RING-Dependent Manner
... cell translation factor, eukaryotic initiation factor 4E (eIF-4E) in infected and transfected ...this translation factor led us to investigate whether Z could modulate host cell ...
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Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation.
... translation approximately sevenfold (Fig. 6C). Overexpression of Paip1 isoforms had no effect on Renilla mRNA levels (Fig. 6D). Thus, the p45 isoform of Paip1 is a more potent transla- tional enhancer than the p65 ...
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