evolution of resistance
Modified Antibiotic Adjuvant Ratios Can Slow and Steer the Evolution of Resistance: Co amoxiclav as a Case Study
... rapid evolution of resistance via increased  -lactamase expression, while low amoxicillin ratios with similar initial efficacies are more robust and maintain the efficacy of our meager pool of  -lactamase ...
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Evolution of Resistance Against CRISPR/Cas9 Gene Drive
... the evolution of resistance against the drive (Burt 2003; Deredec et ...Such resistance could arise, for instance, through alleles at the target locus that cannot be converted by CGD because they are ...
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The evolution of resistance through costly acquired immunity
... of resistance mechanisms are clear. Resistance mechanisms are, however, unlikely to be cost ...of resistance that evolves is therefore a cost–benefit trade-off in terms of evolutionary fitness and as ...
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Genome-Level Evolution of Resistance Genes in Arabidopsis thaliana
... Pathogen resistance genes represent some of the most abundant and diverse gene families found within plant ...generating resistance gene diversity at the genome level are not well ...the evolution of ...
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Evolution of Resistance During Clonal Expansion
... which resistance mutations arise (N owak et ...and resistance is often detected at diagnosis (M ichor et ...develop resistance within the first year of therapy (B ranford et ...
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EVOLUTION OF RESISTANCE IN THE PRESENCE OF TWO INSECTICIDES
... The preliminary experiments by GEORGHIOU (1 983) arrive at similar conclusions. The main conclusion of this paper is that it is always desirable to use mix- tures rather [r] ...
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Mechanisms and evolution of resistance to environmental extremes in animals
... the evolution of novel biosynthetic pathways, but through a breakdown or disruption of existing pathways, leading to the accu- mulation of antioxidant intermediates ...example, evolution of regulatory ...
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NICHE EXPANSION IN BACTERIA: CAN INFECTIOUS GENE EXCHANGE AFFECT THE RATE OF EVOLUTION?
... At any given rate of mutation, the effects of recombination on the evolution of resistance to a set of growth inhibitors, such as antibiotics, are intermediate betwe[r] ...
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An exploration of the dynamics of selection for resistance to herbicides
... herbicide resistance research has focussed on the evolution of major effect resistance alleles (section ...non-target-site resistance mechanisms are also extremely important (Délye et ...
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Risk assessment and preventive strategies for herbicide resistance in NR (phase III)
... glyphosate resistance model devel- oped in this project used the experiments' findings to predict the long-term impacts on evolution of resistance and on seed bank numbers of resistant ...and ...
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A Two Locus Model of the Evolution of Insecticide Resistance to Inform and Optimise Public Health Insecticide Deployment Strategies
... of resistance, often by many orders of ...The evolution of resistance in these contexts are ...of resistance on control, see discussion below around Eq ...to resistance) when comparing ...
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Diversity and evolution of drug resistance mechanisms in <em>Mycobacterium tuberculosis</em>
... ongoing evolution of resistance mechanisms among MTB population is a serious ...drug resistance. These mechanisms include compensatory evolution, epis- tasis, clonal interference, decreased ...
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Framework for an expert evaluation for the evolution of weed resistance
... of evolution of resistance of weeds to herbicides has increased substantially over the past ...herbicide resistance. The opportunities for herbicide resistance are maximized in weeds that ...
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Experimental Prediction of the Natural Evolution of Antibiotic Resistance
... one resistance when we started to feel secure about our victory over gene can give rise to many phenotypically diverse de- microbes, antibiotic-resistant strains of bacteria started scendant alleles, protein ...
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Resistance Evolution against Phage Combinations Depends on the Timing and Order of Exposure
... evolve resistance against multiple phages is lacking, limit- ing our ability to deploy phage combinations ...multiple resistance mutations effective against both phages, this evolutionary trajec- tory was ...
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Molecular Evolution: HIV Drug Targets and Resistance
... For another example, the first antiretroviral drug devel- oped for HIV, AZT, is a chemical compound similar in structure to DNA nucleotides. AZT blocks the action of the reverse transcriptase enzyme. Early testing of AZT ...
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The Evolution of Fitness Modifiers and Their Impact on Insecticide Resistance.
... managing resistance has been rotation of modes of ...a resistance management strategy despite mixed evidence of effectiveness (Gould et ...of resistance as modifiers ameliorate any fitness costs of R ...
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TWO-STEP RESISTANCE BY ESCHERICHIA COLI B TO BACTERIOPHAGE T2
... B/6 ara- xyl- str' T6' S. This result indicates that the evolution of T2 resistance by E. coli B can be accelerated by prior selection for resistance to phage T4. If [r] ...
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Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131
... Intermediate strains reveal key MGE acquisitions that define clade C. Overall, excluding intermediate B0 and C0 strains, clade C differs from clade B by only 42 substitution SNPs (Tables 1 and 2). This list included the ...
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Modelling evolution and management of glyphosate resistance in Amaranthus palmeri
... Simulated evolution of glyphosate resistance in ...genotype). Resistance risk is a measure of the proportion of populations (of 1000 runs) in which resistance is predicted at simulation year ...
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