Excision repair
The Nucleotide Excision Repair Pathway Limits L1 Retrotransposition
... DNA repair pathways, limits L1 retrotransposition (Gasior et ...damage repair, notably in the removal of the DNA flap structures during single-strand annealing (SSA) repair of DSBs (Sargent et ...
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Global Genome Nucleotide Excision Repair Proteins Rhp7p and Rhp41p Are Involved in Abasic Site Repair of Schizosaccharomyces pombe
... nucleotide excision repair (NER) proteins in removing UV-induced lesions are well ...base excision repair (BER) genes during abasic (AP) site repair of Schizosaccharo- myces ...in ...
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Base flipping in nucleotide excision repair
... several repair mechanisms have evolved to avoid these ...nucleotide excision repair (NER) 2 is characterized by the unique feature that it is able to recognize and repair a large variety of ...
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Base excision repair and the role of MUTYH
... Base excision repair (BER) is one of the most important DNA repair pathways, which ameliorates environmentally induced DNA damage, including that which arises spontaneously as a result of alkylation, ...
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
... Nucleotide excision repair (NER) is a versatile DNA repair pathway, which can remove an extremely broad range of base lesions from the ...the repair reaction by recognizing sites of DNA ...
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Studies on protein:protein interactions in mammalian DNA base-excision repair
... Base excision repair (BER) first became known in 1974 with the discovery of uracil DNA glycosylase, while searching for an enzyme that could remove deaminated cytosines (Lindahl, ...complete repair ...
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Why Is DNA Double Stranded? The Discovery of DNA Excision Repair Mechanisms
... DNA repair held in Chicago in 1965 (Haynes et ...in excision repair (Reiter and Strauss 1965) since, along with other evidence, this strain did not repair UV-induced or nitrogen ...
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Functional studies of accessory factors associated with base excision repair
... base excision repair (BER) and single strand break repair (SSBR) (Caldecott, 2003a; Caldecott, ...pathways repair damage to DNA bases, from oxidation or covalent binding of non- bulky ...
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Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes
... mismatch repair proteins MutS and MutL correct replication errors and prevent recombination between homeologous (nonidentical) ...nucleotide excision repair proteins Rad1p and Rad10p were found to ...
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Nucleotide excision repair deficiency in melanoma in response to UVA
... damage. Repair of UVA-induced DNA damage is thought to occur primarily through the Nucleotide Excision Repair (NER) pathway, which recognises and repairs damage either coupled to transcription ...
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Nucleotide excision repair in aging & cancer
... Survival studies without directed exposure were performed initially in a mixed genetic background, i.e. C57BL/6J/Ola129[ 81 ] and C3H/heN strains[ 77 ] and in fairly small numbers. However, both studies indicated that ...
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Interactions and function of nucleotide excision repair complexes
... There is also evidence for higher o rd er in teractio n s b etw een NER p ro te in s. Svejstrup et al. (Svejstrup et al. 1995) an d R o d rig u ez et al. (R odriguez et al. 1998) purified NER proteins from S. cerevisiae ...
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The XPC-hHR23b complex and nucleotide excision repair of DNA
... The excision products and annealing controls w ere labeled w ith ...In repair reactions, all reaction products betw een 24-32 n t w ere counted during ...
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IDENTIFICATION OF A SECOND LOCUS IN DROSOPHILA MELANOGASTER REQUIRED FOR EXCISION REPAIR
... Unlike the excision-defective mei-9 mutants identified in previ- ous studies, the mus(2)ZM mutants do not affect female fertility and do not appear to influence recombi[r] ...
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BACTERIOPHAGE T4 GENE 32 PARTICIPATES IN EXCISION REPAIR AS WELL AS RECOMBINATIONAL REPAIR OF UV DAMAGES
... Specifi- cally, defects in pairing of complementary DNA strands (of different paren- tage) across UV damages would reduce potential repair of damaged DNA by recomb[r] ...
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Excision repair and patch size in UV-irradiated bacteriophage T4.
... Loss of thymine dimers from phage DNA, as measured by thin-layer chromatography % of thymine in dmUVers .coli straoin strai Phage td8 denV+ td+ denVi S/6/5 S/6/5 % of di- The appearance [r] ...
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Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus
... damage repair and apoptosis pathways was analyzed in untreated PBMCs by RT 2 Profiler™ PCR Array ...nucleotide excision repair (DDB1, ERCC2, XPA, XPC), double-strand breaks repair (BLM, CHEK1, ...
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The Large Subunit of Replication Factor C (Rfclp/Cdc44p) Is Required for DNA Replication and DNA Repair in Saccharomyces cerevisiae
... induced single-stranded DNA breaks at the restrictive temperature is consistent with the hypothesis that Cdc44p plays a role in the DNA excision repair pathway.. DISCUSS[r] ...
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<em>ERCC1</em> rs3212986 A/C polymorphism is not associated with chemotherapy treatment outcomes in gastric cancer patients: evidence from 11 publications in Chinese populations
... DNA repair systems play an important role in repairing the damage to DNA induced by endogenous and/or exogenous factors such as therapeutic ...Nucleotide excision repair (NER) is a key DNA ...
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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA
... Recent studies using purified human TOP1 suggest further distinct processing of the released DNA (Fig. 2): (1) re-ligation of the nick; (2) strand cleavage by TOP1 a few nucleotides upstream from the nick, leading to the ...
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