exendin-4
Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy
... needed. Exendin-4 is a drug used to treat type 2 diabetes mellitus that has also demonstrated neuroprotective properties, and is currently being tested in clinical trials for Alzheimer’s and Parkinson’s ...
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Radiosynthesis and evaluation of an 18F–labeled silicon containing exendin-4 peptide as a PET probe for imaging insulinoma
... beled exendin derivatives (Jodal et ...for exendin (Wu et ...an exendin-4 containing forty amino acids using a single step and without a prosthetic ...new exendin-4 derivative ...
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Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon like peptide receptor agonist, exendin 4, in the conscious telemetered ferret
... of exendin-4 (see below) or as a reflex consequence of exendin-4 action on abdominal vagal afferents ...tered exendin-4 is consistent with previous studies using Suncus murinus ...
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A comparison of three 67/68Ga-labelled exendin-4 derivatives for β-cell imaging on the GLP-1 receptor: the influence of the conjugation site of NODAGA as chelator
... to exendin-4, for example a fluorescent dye and a chelator, which could be used as a probe for dual ...Ga-labelled exendin derivative [Lys 40 ( 68 ...
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Evaluation of an [18F]AlF-NOTA Analog of Exendin-4 for Imaging of GLP-1 Receptor in Insulinoma
... = 4) by 5 min and remained nearly constant for the duration of the ...of exendin-4 caused a marked reduction in tissue uptake with the major exception of liver and kidneys, in which uptake was not ...
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Original Article The effect of Exendin-4 on apoptosis of islet cells in rats with type I diabetes
... of Exendin-4 on apoptosis of type I diabetes rat β-cells and provide data support for clinical ...and Exendin-4 intervention group (treated ...ng/kg Exendin-4 inter- vention, at ...
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Targeting Altered Mitochondrial Biogenesis in the Brain of Diabetic Rats: Potential Effect of Pioglitazone and Exendin-4
... analog: exendin-4 (Ex-4) in neurological diseases were reported, but whether mitochondrial biogenesis is involved or not in their neuro-protective mechanisms in type 1 Diabetes Mellitus (T1DM); has ...
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64Cu Labeled Sarcophagine Exendin-4 for MicroPET Imaging of Glucagon like Peptide-1 Receptor Expression
... radiometal-labeled exendin-4 can be signif- icantly reduced by the administration of a plasma expander such as Gelofusine and PGA[15, 39] without an additive effect on GLP-1R targeting of radiolabeled ...
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Original Article Exendin-4 protects retinal pigment epithelial cells against oxidative stress in vitro via PI3K/Akt-STAT3 activation
... of Exendin-4, as well as its relation with PI3K/Akt signaling, the p-STAT3 inhibitor was also supplemented during the Exendin-4 administration under oxi- dative stress ...on ...
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Original Article Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway
... hormone. Exendin-4 is the longacting GLP-1 receptor agonist that used as an anti-diabetic ...demonstrated exendin-4 has a series of beneficial neuroprotective ...of exendin-4 ...
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Original Article Effect of exendin-4 on the expression of CXCL10 and its receptor in type I diabetes rats
... unknown. Exendin-4 is one potent agonist for GLP-1 receptor with high affinity on pancreatic GLP-1 receptor ...of Exendin-4 on islet β cells in T1DM model ani- mal in addition to the ...
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Comparison of desferrioxamine and NODAGA for the gallium-68 labeling of exendin-4
... Ga-NODAGA-exendin-4 PET/CT for Diagnostic Imaging in AHH n.d.). Furthermore, NODAGA is used in pre- clinical imaging studies with gallium-68 and it is also frequently investigated with copper-64, another ...
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Exendin 4 and sitagliptin protect kidney from ischemia reperfusion injury through suppressing oxidative stress and inflammatory reaction
... of exendin-4 six ...or exendin-4 compared with those re- ceiving low doses of the two ...of exendin-4 were utilized in the current ...IR), 4) IR + sita- gliptin 600 mg/kg ...
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Long-acting inhalable chitosan-coated poly(lactic-co-glycolic acid) nanoparticles containing hydrophobically modified exendin-4 for treating type 2 diabetes
... Abstract: Inhalable glycol chitosan-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles containing palmitic acid-modified exendin-4 (Pal-Ex4) (chitosan Pal-Ex4 PLGA NPs) were prepared and ...
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Exendin-4 enhances the differentiation of Wharton’s jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers
... of exendin-4 for the differentiation of WJ-MSCs into ...that exendin-4 could in- duce early and late markers along the differentiation ...
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Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging
... radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell ...to exendin-4, to label β cells for clinical imaging with ...
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Exendin 4 in combination with adipose derived stem cells promotes angiogenesis and improves diabetic wound healing
... HUVECs or HaCaT cells were plated on 24-well plates (Nunc, Rochester, NY, USA) and grown to 90% conflu- ence. Cells were wounded with a 1-mm-wide pipette tip, and the injury line was marked. After wounding, the cultures ...
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Effects of exendin-4, a glucagon like peptide-1 receptor agonist, on neutrophil count and inflammatory cytokines in a rat model of endotoxemia
... In this study, we report that treatment with Ex-4 decreases pro-inflammatory cytokine levels, with no effects on IL-10 levels in the early phase of LPS-induced endotoxemia. We also show attenuation of neutropenia ...
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Exendin-4 ameliorates cardiac ischemia/reperfusion injury via caveolae and caveolins-3
... Nutrient-responsive intestinal hormones including GLP-1 are rapidly metabolized by enzyme dipeptidyl-peptidase-4 (DPP-4) to generate an N-terminally truncated metabolite GLP-1 (9–36) [1,29]. Previous ...
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Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes
... Embryonic stem cells (ES) can self-replicate and differentiate into all cell types including insulin- producing, beta-like cells and could, therefore, be used to treat diabetes mellitus. To date, results of stem cell ...
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