Experimental Colitis
Role of peripheral dopaminergic system in the pathogenesis of experimental colitis in rats
... without colitis, but significantly decreased in both saline- and MPTP-treated rats with ...of experimental colitis, which might be through the regulatory effect of dopaminergic system on monocytes ...
12
Original Article Changes in the phosphorylation of claudins during the course of experimental colitis
... Claudins are the major membrane proteins forming continuous TJ strands and interact in a tissue-specific manner to form a charge-selec- tive and size-selective barrier [3, 16]. The down- regulation of claudins has been ...
9
IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice
... It has previously been demonstrated that IL-33 increases the expression of the LPS receptor compo- nents MD2 (myeloid differentiation protein 2) and TLR-4, the soluble form of CD14 and the MyD88 adap- tor molecule. In ...
9
Tissue Factor-Dependent Chemokine Production Aggravates Experimental Colitis
... aggravates experimental colitis depending on the signaling properties of ...ulcerative colitis (52), and PAR-2 deficiency was protective in DSS-, 2,4,6-trinitrobenzenesulfonic acid (TNBS)- and ...
8
Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis
... alleviate experimental colitis, we created MSC spheroids in vitro and injected them in mice with established DSS-induced coli- ...DSS-induced colitis when given in a high dose, which was accompanied ...
12
Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis
... effect of intraperitoneally injected MSCs in experimental col- itis. Our data indicate that not a single pathway, but the inter- play between several pathways is most likely responsible for the anti-inflammatory ...
13
Fatty Acid Synthase Inhibitor C75 Ameliorates Experimental Colitis
... in colitis mice inhibited the ele- vation of FASN, cyclooxygenase-2 and inducible nitric oxide synthase expression as well as I κ B degradation in colon ...
9
Oral Escherichia coli expressing IL 35 meliorates experimental colitis in mice
... Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) characterized by chronic inflam- mation of ...(DSS)-induced experimental colitis in mice for the first ...
10
Anti inflammatory effect of Chang An Shuan on TNBS induced experimental colitis in rats
... According to the Chinese medical theory, the symp- toms of UC are derived from the imbalance of Qi ac- companied with dampness or cold-dampness in the spleen and intestine. BaiTouWeng decoction (BTWD) is a traditional ...
8
Suppression of inflammation and tissue damage by a hookworm recombinant protein in experimental colitis
... Gastrointestinal parasites, hookworms in particular, have evolved to cause minimal harm to their hosts when present in small numbers, allowing them to establish chronic infections for decades. They do so by creating an ...
9
Apolipoprotein A IV inhibits experimental colitis
... of colitis assessed by overall score as well as specific parameters (inflammation, extent, and crypt damage; see Methods for param- eter values and scores) was significantly higher than that in con- trols (Figure ...
11
Reversal of experimental colitis disease activity in mice following administration of an adenoviral IL-10 vector
... Experimental colitis produced by DSS is thought to share many important characteristics with forms of human inflammatory bowel ...spontaneous colitis with many of the characteristics of human IBD and ...
10
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis
... to colitis in several different experimental colitis models, including the TNBS and DSS models, in which acute colitis is induced chemically, and the adoptive T cell transfer model, in which ...
15
Effect of Concentrated Apple Extract on Experimental Colitis Induced by Acetic Acid
... A possible explanation for improvement of AA-induced damage was the preservation of goblet cells in the epithelium of the rats treated with CAE. It is known that goblet cells are responsible for mucin production. Mucins ...
12
Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription
... DSS colitis, these levels decrease spontaneously and eventually return to baseline despite ongoing severe ...DSS colitis despite its ability to significantly lower colonic TNF levels, these data sug- gest ...
13
Collagen binding integrin α1β1 regulates intestinal inflammation in experimental colitis
... allowing migration of leukocytes to inflammatory sites, it is also capable of promoting cellular activation. For instance, integrin-mediated binding to collagen provides a costimulatory signal for T cell activation, ...
11
Epithelial hypoxia inducible factor 1 is protective in murine experimental colitis
... and experimental coli- tis (6, 7) suggest the presence of colonic hypoxia and its significance in the disease ...of colitis (Mdr1-null) (11) or increased susceptibility to chemically induced colitis ...
10
Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles
... in colitis rats, which mimicked UC patient ...of colitis rats treated with Azo-pu ES NPs showed no pathological symptoms, and looked similar to healthy control sections (Figure ...
16
Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice
... In the recent years, stem cell-based therapy as a promis- ing alternative solution draws considerable attention for UC treatment. As an attractive candidate in cell therapy, mesenchymal stem cells (MSCs), a group of ...
11
Genetic deletion of dectin-1 does not affect the course of murine experimental colitis
... an experimental model of DSS ...during colitis (Figure 1A and 1B) and the lack of dectin-1 leads to reduced production of TNF-a and IL-10 production by macrophages we hypothesised that dectin-1 deficient ...
10