Expression of MHC Class I and β 2 M
DNMT1 regulates expression of MHC class I in post-mitotic neurons
... total MHC-I pro- tein in neurons, not even in the neurons displaying the highest uptake of siRNA against DNMT1 ...surface MHC-I, and the possibility that intra- cellular MHC-I ...
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Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I
... by a wide variety of cells and is not subject to viral regulation that affects other NK cell receptor ligands, such as MHC-I and NKG2D ligands. It is interesting that m157 is expressed on MCMV-infected ...
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Class I molecules of the MHC function to display peptides
... TAP Dependence of Antigen Presentation. The involvement of TAP in the presentation of NP, NP N , SNP, and SNP N was examined using T2-K d cells, a TAP-deficient human lymphoblastoid cell line expressing K d from a ...
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Downregulation of MHC class I molecules by human cytomegalovirusencoded
... prevent MHC class I surface ...of MHC class I ...retains MHC class I molecules in the ER and specifically affects those types of MHC class ...
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Prevalent expression of the immunostimulatory MHC class I chain–related molecule is counteracted by shedding in prostate cancer
... MIC expression in prostate carcinoma and the susceptibility of MIC- expressing prostate cancer cells to NK cell activation, suggesting that MIC-NKG2D tumor immune surveillance can play an impor- tant role in the ...
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Studies of MHC class I antigen presentation & the origins of the immunopeptidome
... appendices 2 & 3, we carried out a single experiment using triplicate analysis of 2 cell lines for each allele ...HLA-A,B expression following MAE and protease treatment at different rates (Figure ...
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Structural Mechanism of ER Retrieval of MHC Class I by Cowpox
... MHCI expression using PLC-dependent versus PLC-independent mechanisms, ...soluble class I-like protein OMCP that functions as a competitive antagonist of the NKG2D- activating receptor ...
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Association of CD99 short and long forms with MHC class I, MHC class II and tetraspanin CD81 and recruitment into immunological synapses
... the expression of several T cell activation markers on anti-CD3-activating T cells, elevation of intracellular Ca2 + and the tyrosine phos- phorylation of cellular proteins ...
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IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
... and MHC class I overexpression, three hallmarks of islet histology in early type 1 ...whether expression of these mediators of beta cell loss is reversible upon IFNα withdrawal or IFNα pathway ...
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Expression, purification and characterization of ricin vectors used for exogenous antigen delivery into the MHC class I presentation pathway
... In order to characterize the chimera, both the early fractions (4-12), containing predominantly the higher band, and the later fractions (14-22) were separately pooled and concentrated. The proteins were dialysed into a ...
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Characterization of a Murine Cytomegalovirus Class I Major Histocompatibility Complex (MHC) Homolog: Comparison to MHC Molecules and to the Human Cytomegalovirus MHC Homolog
... surrogate class I pro- teins, capable of engaging NK cell inhibitory receptors and protecting cells that lack class I surface ...mouse class I MHC molecules different from ...
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MHC Class I Tranitalization - The Design of a TAP Deficient CD8 CTL
... TAP1yb 2 m 2y2 mice, as well as H-2K b transfected and control T2 cells, show that at least a part of the response is directed against epitopes that depend on the expression of MHC ...
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Cloning, Expression, and Functional Analyses of MHC Class II A in Ayu, Plecoglossus altivelis
... The MHC (major histocompatibility complex) class II family plays a major role in vertebrate immune systems and is normally found only on antigen-presenting ...of MHC class II molecules in ayu ...
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MHC Class II Expression in Human Basophils: Induction and Lack of Functional Significance
... induce MHC Class II ...(10 m g/ml) or medium alone was also added to the basophil stimulation ...of 2 mM L-glutamine, 100 IU/mL penicillin-streptomycin and 5% human AB serum in RPMI-1640 ...
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Blocking oncogenic RAS enhances tumour cell surface MHC class I expression but does not alter susceptibility to cytotoxic lymphocytes
... restricted MART-1 reactive T cells and MART-1 peptide pulsed tumour target cells was suggestive of reduced CTL responses against H Mu , but these results did not reach statistical significance. Overall, mutant KRAS ...
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Downregulation of MHC class I molecules by human cytomegalovirus-encoded US2 and US11
... y m odulating surface expression of MHC class I m ...e m ost efficient if th e v irus w ould selectiv ely dow n-reg ulate v iral antig en- presenting alleles, w h ile at ...
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Enhanced major histocompatibility complex (MHC) Class I1 antigen expression in lupus nephritis
... HLA-DR expression was noted in the arteries of the normal kidney tissue, 4 were surrounding malignancies (2 renal cell carcinomas, 1 Wilms' tumour and 1 metastatic endometrial ...HLA-DR expression in ...
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Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking
... complex class I molecules (MHC-I) and CD4 and CD28 cell surface ...on MHC-I have been shown to protect infected cells from cytotoxic T-lymphocyte recognition by downmodulation of ...
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Polymorphism of duck MHC class molecules
... Anpl-MHC I also plays a role in suscep- tibility to viral ...high expression of MHC I and the high resistance of some duck lines to avian influenza virus, Newcastle disease virus, or ...
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Mechanisms involved in regulation of MHC class I molecules in murine embryonic stem cells
... of MHC class I in ESCs and ES-CMs The role of MHC class I in the initiation and extent of NK cell-dependent killing has been extensively investigated and debated as the concept ...
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