Expression of PD-L1
Modulating PD-L1 expression in multiple myeloma: an alternative strategy to target the PD-1/PD-L1 pathway
... of PD-L1 IHC for predicting response to immune checkpoint ...the expression of PD-L1 by IHC is generally associated with a higher proportion of objective response, [72] patients without ...
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Reactive versus Constitutive: Reconcile the Controversial Results about the Prognostic Value of PD-L1 Expression in cancer
... of PD-L1 expression, we divided tumors into four tumor microenvironment (TME) types according to the median expression of PD-L1 and CD8A, in which TME III is CD8A-low and ...
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Basal cell carcinoma: PD-L1/PD-1 checkpoint expression and tumor regression after PD-1 blockade
... Because PD-Ligand-1 (PD-L1) expression in other tumor types has been associated with response to anti-PD-1, we investigated the expression of PD-L1 and its ...
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PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
... The expression of PD-L1 on tumor cells or tumor-infiltrating immune cells by immunohistochemistry (IHC) has become the most widely used biomarker for selecting patients for ICI therapy ...the ...
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<p>Detection of PD-L1 Expression and Its Clinical Significance in Circulating Tumor Cells from Patients with Non-Small-Cell Lung Cancer</p>
... the expression of PD-L1 in TTs is related to the therapeutic effect of patients receiving corresponding immune checkpoint ...the expression of PD-L1 in TTs can be dynamically ...
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<p>Growth and differentiation factor 15 regulates PD-L1 expression in glioblastoma</p>
... for PD-1, is predominantly expressed in cancer cells. 9 PD-L1 expressed in various cancer cells can help immune evasion by interacting with PD-1 on T ...intrinsic PD-L1 had ...
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CD84 regulates PD 1/PD L1 expression and function in chronic lymphocytic leukemia
... of PD-L1/PD-1 expression by ...regulates PD-L1 expression and T cell function in cells derived from patients with ...and PD-L1 cell-surface expression ...
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Autophagy inhibition enhances PD-L1 expression in gastric cancer
... with PD-1 inhibitor therapy [42]. PD-L1 expression can be induced by inflammatory cytokines or tumor-cell intrinsic signaling, including NF-κB, MAPK, PI3K, mTOR and ...the expression of ...
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Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1
... of PD-L1 expression [8, 9]. Many different clones of PD-L1 antibodies have been tested in different tumors, in academic studies or clinical trials, as on different immunohistochemistry ...
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Host expression of PD L1 determines efficacy of PD L1 pathway blockade–mediated tumor regression
... tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains ...to PD-L1 blockade and demonstrated a loss of therapeutic efficacy ...
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Kaposi’s Sarcoma Associated Herpesvirus Increases PD L1 and Proinflammatory Cytokine Expression in Human Monocytes
... upregulates PD-L1 surface expression on ...the PD-1–PD-L1 ...express PD-L1 ...alter expression of ...and PD-L1 levels were measured via cell ...
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A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments.
... of PD-L1 at different time points, ...of PD-L1 expression only at 3 weeks as 3 weeks was considered to be a more relevant time point while exploring mechanisms of resistance to targeted ...
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Abundant PD-L1 expression in Epstein-Barr Virus-infected gastric cancers
... In order to study PD-L1 protein expression in EBV+ gastric cancers in relation to 9p24.1 amplification, formalin-fixed, paraffin-embedded (FFPE) tissue sections were retrieved from tumor block of 12 ...
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Scoring of PD-L1 expression intensity on pulmonary adenocarcinomas and the correlations with clinicopathological factors
... between PD-L1 expression and clinicopathological characteristics should be disaggregated by histological type, given the variabil- ity in clinicopathological characteristics between pul- monary ...
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Transformation of ALK expression and PD-L1 0% to PD-L1 90% only after surgery: the need for rebiopsy in lung cancer patients
... heart problems and a normal spirometry; however; she and her relatives denied surgery and next generation sequencing was performed. Additionally, fluorescence in situ hybridiza- tion (FISH) was performed and revealed ALK ...
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PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
... between PD-L1 expression on tumor cells and ORR has been first suggested by the phase I study of Topalian et ...with PD-L1 negative tumor obtained an ORR, while about one third of ...
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PD-L1 expression in human cancers and its association with clinical outcomes
... Abstract: PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the progression of ...of PD-L1 in cancers such as gastric cancer, hepatocellular ...
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Original Article PD-L1 is correlated with p53 expression in patients with lung adenocarcinoma
... Abstract: PD-L1 plays a key role in immune evasion of tumor cells, and individual study found that PD-L1 status was regulated by p53 ...Whether PD-L1 expression is related ...
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PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence
... for PD-L1 expression measured by immunohistochemistry analyses suggested that pretreatment PD-L1 expression by tumors might represent a useful marker predicting response to ...
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Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer
... high expression of PD-L1 and APE1 is a risk factor of gastric cancer and a new biomarker to predict the prognosis of gastric cancer, further indicating the potential therapeutic targeting value of ...
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