F-box only protein 4
F box protein FBXW7 inhibits cancer metastasis in a non cell autonomous manner
... NOTCH accumulation in FBXW7-deficient BMSCs promotes metastasis by increasing CCL2 production. Immunoblot analysis revealed that, among the FBXW7 substrates examined, NOTCH1 intracellular domain (NICD1), c-MYC, and KLF5 ...
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The F box protein ZEITLUPE controls stability and nucleocytoplasmic partitioning of GIGANTEA
... the F-box protein ...GI-GFP protein levels in ...and protein levels determined by ...GI protein were normalized to ADK and H3, respectively, and further normalized to empty ...
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Multiple roles of the F box protein Slimb in Drosophila egg chamber development
... In the germarium, a lineage of intercyst FC differentiates into two subpopulations that stop dividing and originate stalk and polar cells (Bai and Montell, 2002; Margolis and Spradling, 1995; Tworoger et al., 1999). The ...
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F-Box Protein RcyA Controls Turnover of the Kinesin-7 Motor KipA in Aspergillus nidulans
... required only during certain stages or for special events and thus the turnover of such compo- nents needs to be strictly regulated ...the F-box do- main of different proteins. F-box ...
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The F-Box Protein Fbp1 Regulates Sexual Reproduction and Virulence in Cryptococcus neoformans
... the F-box protein Fbp1. To understand the function of F-box proteins in ...an F-box domain in the H99 genome database ...and only one (CNAG_05280.2) contains LRRs; ...
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A novel F box protein is required for caspase activation during cellular remodeling in Drosophila
... at 4°C. Protein concentration was determined by Bradford assay (BioRad), and 30-50 g total protein, dissolved in SDS loading buffer, was separated by ...
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Baculovirus F-Box Protein LEF-7 Modifies the Host DNA Damage Response To Enhance Virus Multiplication
... and 4), it is unlikely that LEF-7 degrades ...example, F-box protein SKP2 promotes K63-linked polyubiquitination of NBS1 (46), a component of the host Mre11-Rad50-Nbs1 (MRN) ...viral ...
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The F Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformans
... donor mice. In brief, splenic cell suspensions were depleted of T cells by antibody-complement-mediated lysis. Splenic cells were incubated with anti-Thy1.2 antibodies and rabbit complement (Low Tox; Cedarlane Labs, ...
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F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression
... factor 4 (KLF4), a member of the KLF family of transcription factors, has been considered as a crucial tumor suppressor in hepatocellular carcinoma ...that F-box only protein 22 ...
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An Arabidopsis F box protein acts as a transcriptional co factor to regulate floral development
... LFY-FLAG protein is post-translationally modified and stabilized in the presence of ...LFY-FLAG protein as detected by ␣ FLAG antibodies shows a prominent band of LFY-FLAG protein at approximately 55 ...
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Original Article Down-expression of F box only protein 8 correlates with tumor grade and poor prognosis in human glioma
... fer (pH 8.0) and microwaved. The classical avi- din-biotin peroxidase complex (ABC) procedure was used for immunohistochemistry. In the ABC system, endogenous peroxidase was quenched by incubation of the sections in 0.1% ...
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F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans
... (Figure 4, D and E). Similar effects of xrep-4 OE on skn-1-dependent gene expression, juglone resistance, and longevity were observed in two other inde- pendent xrep-4 OE lines (Figure S1 in File ...
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Opposite Roles of the F-Box Protein Rcy1p and the GTPase-Activating Protein Gyp2p During Recycling of Internalized Proteins in Yeast
... no protein (vector) or Gyp2p (Gyp2p) from the inducible GAL pro- ...no protein (vector) or Gyp2p (Gyp2p) from the in- ducible GAL promoter were analyzed by electron microscopy 4 hr after addition of ...
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The F box protein family
... of F-box proteins, and in all but a couple of cases this analysis was performed with overex- pressed tagged proteins (see for example the supplementary material in ...Some F-box proteins were ...
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Lessons from Fungal F-Box Proteins
... the F box, the LRR, or both domains were nonfunctional both in the interaction with ...in F. graminearum, protein turnover is required for sexual reproduc- tion, but whether the ortholog of ...
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An immune stratification reveals a subset of PD 1/LAG 3 double positive triple negative breast cancers
... Interestingly, by analyzing two independent cohorts, we found that PD-1+ and LAG-3+ TILs were concur- rently expressed in approximately 15% of TNBC cases. Thus, reversing the phenotype of exhausted T lympho- cytes by ...
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The Saccharomyces cerevisiae F-Box Protein Dia2 Is a Mediator of S-Phase Checkpoint Recovery from DNA Damage
... in protein turnover during cell-cycle progression (Ang and Harper ...an F-box protein, which provides specificity of the com- plex (Feldman et ...cerevisiae F-box protein ...
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Decreased Dependence on Receptor Recognition for the Fusion Promotion Activity of L289A-Mutated Newcastle Disease Virus Fusion Protein Correlates with a Monoclonal Antibody-Detected Conformational Change
... mutated F protein when it is coexpressed with each of these functionally deficient HN proteins ...wt F in the pro- motion of fusion at more than 3% of the wt ...HN protein with L289A-F ...
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Cloning and Bioinformatics Analysis of Rosa rugose S Locus F Box Gene (RrSLF)
... Rosa rugosa is a famous traditional Chinese flower of the genus Rosa . It is not only an important flowering plant, but its fruits also have considerable orna- mental, edible and medicinal values. Ornamental fruit ...
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Regulation of SCF ubiquitin ligases by Jab1/Csn5 and the Cop9 signalosome
... several protein bands found in hCul1 IPs but not in controls (Figure ...several F-box proteins, eight proteins were identified that corresponded to the entire complex of the Cop9 Signalosome ...
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