Family-based association study
A logistic mixture model for a family based association study
... A family-based association study design is not only able to localize causative genes more precisely than linkage analysis, but it also helps explain the genetic mechanism underlying the trait ...
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A Powerful Nonparametric Statistical Framework for Family-Based Association Analyses
... PS based on a large number of genetic variants, but not the locus-specific ...studies, family-based studies offer robust protection against PS (Weinberg et ...typical family-based ...
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Association of ENPP1gene polymorphisms with hand osteoarthritis in a Chuvasha population
... a family-based association study to test the hypothesis that genetic variation at the ENPP1 locus is involved in the etiology of osteoarthritis of the ...The study population comprised ...
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Association of a rare NOTCH4 coding variant with systemic sclerosis: a family based whole exome sequencing study
... the family described here is supported by the known impact of NOTCH4 intracellu- lar domain expression on the vascular endothelium in mouse models and the role of endothelium in the devel- opment of ...a ...
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Family based genome wide association of inflammation biomarkers and fenofibrate treatment response in the GOLDN study
... multiloci association of response to fenofibrate treatment with the genomic regions, which reduces the chance of missing a moderately associated ...the association of sin- gle variants using multiple TG and ...
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Variants in estrogen biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family based genetic association study
... the association can be done on the basis of the deviation of these statistics from the standard critical values under normal ...each family. These family-specific scores are obtained in three ...
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Implicit Hypotheses Are Hidden Power Droppers in Family Based Association Studies of Secondary Outcomes
... popular family-based test of associa- tion (Spielman et ...any association between the genetic marker and the disease under ...complex family structures ...of association between two ...
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The Genetic Overlap Between Hair and Eye Color
... Genome-Wide Association Study (GWAS) in a Dutch Caucasian family-based population sample and examined the genetic correlation between hair and eye color using data from unrelated participants ...
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The Active Role of Material Things: An Environment Based Conceptual Framework to Understand the Well Being of People with Dementia
... this study is to explore in specific terms how material things resonate with people with de- mentia in the real ...the study of Seamon (1979), have been classified into various types that cover different ...
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Testing for the association of the KIAA1109/Tenr/IL2/IL21gene region with rheumatoid arthritis in a European family based study
... Rheumatoid arthritis (RA) is a common autoimmune inflammatory disease of unknown cause, in which both genetic and environmental risk factors have been impli- cated [1]. Since the genetic contribution to RA has been ...
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Combining multiple family based association studies
... We implement the imputation step using the loess func- tion in R. The choice of the smoothing parameter depends on many factors such as the age of the disease mutation, the population under study, and the marker ...
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Association between social and family support and antenatal depression: a hospital based study in Chengdu, China
... hospital in Chengdu, one of the central cities in Southwest China. Questionnaires were given to pregnant women who were scheduled for antenatal screening in one of the four hospitals, and each woman completed the ...
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Family based Bayesian collapsing method for rare variant association study
... [10], have been proposed for RV association detection. Because of the large scale of model space and matrix cal- culation, these approaches suffer from impractical com- putational time if a full joint posterior ...
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Association of MICA with rheumatoid arthritis independent of known HLA DRB1risk alleles in a family based and a case control study
... MICA association from HLA-DRB1 risk alleles, a likelihood ratio test (LRT) was ...an association of the MICA polymorphism independ- ent of the known association of HLA-DRB1 ...
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Within Day Energy Balance and the Relationship to Injury Rates in Pre Professional Ballet Dancers
... other family members and peers who may serve as attachment ...extended family members play an important support role and thus there are other family members, besides parents, who can attend to the ...
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... hospital based cross sectional study conducted in Department of Psychiatry, ...This study was intended to assess hopelessness and suicidal ideation among patients with depression and neurotic ...
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Strategic practices of family firms: an empirical study of Australian family firms
... of family firms across their firm life cycle. The findings of the study suggest that while differentiation strategy is significant to family firms, diversification strategy is less ...addition, ...
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Adolescent depressive disorders and family based interventions in the family options multicenter evaluation: study protocol for a randomized controlled trial
... and family stresses ...the family system were produced in mental health and stress symptoms, family cohesion and increases in action by young people to address their substance use ...improved ...
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Comparing family based rare variant association tests for dichotomous phenotypes
... variant association analysis with population-based samples might suffer from the genetic heterogeneity between affected individuals, and various analysis strategies, such as selecting individuals with ...
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Power Evaluations for Family-Based Tests of Association With Incomplete Parental Genotypes
... A complex trait model: So far, most of the simulation assume ⫽ 0.5. Additional simulations are conducted studies evaluating power of family-based association tests to examine effects of different ...
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