Farnesoid X receptor
Farnesoid X receptor is essential for normal glucose homeostasis
... The farnesoid X receptor (FXR; NR1H4) is a member of the nuclear receptor superfamily that is primarily expressed in liver, kidney, and ...retinoid X receptor and binds inverted ...
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Farnesoid X receptor represses hepatic human APOA gene expression
... whether farnesoid X receptor (FXR), which is activated by bile acids, was responsible for the low plasma Lp(a) levels in cholestatic patients and mice, we treated tg-APOA and tg-APOA/Fxr –/– mice ...
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Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism
... of farnesoid X receptor (FXR) signaling has beneficial effects on the development of obesity ...nuclear receptor that regulates the homeostasis of bile acids, lipids, and glucose ...
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Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells
... Fig. 1 Correlation of farnesoid X receptor (FXR) and microRNA-23b-3p expression in osteosarcoma (OS) cells and miR-23b-3p specifically targets cyclin G1 (CCNG1). As FXR might regulate the expression ...
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Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma
... The association between the temporal activation of Wnt/β-catenin pathway and the spontaneous hepatocellular carcinoma (HCC) development in Farnesoid X receptor (FXR) knockout mice is not well ...
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra and extrahepatic cholestasis
... Farnesoid X receptor (FXR) is a bile acid–activated transcription factor that is a member of the nuclear hormone receptor superfamily. Fxr-null mice exhibit a phenotype similar to Byler ...
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Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication
... In the small intestines, where rotavirus replication occurs, de novo synthesis of lipids and absorption of dietary lipids affect cellular lipid contents in the epithelial cells (19). In the intes- tinal lumen, bile acids ...
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Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis
... Abstract: Non-alcoholic steatohepatitis (NASH), characterized by hepatocyte injury, inflammation, and fibrosis, is the main cause of chronic liver disease in the Western world. There are currently no approved ...
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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
... influences NAFLD pathogenesis. Here, a murine model of high-fat diet–induced (HFD-induced) NAFLD was used, and the effects of alterations in the gut microbiota on NAFLD were determined. Mice treated with antibiotics or ...
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Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis
... Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in the world. The clinical-histological spectrum of NAFLD includes two major phenotypes, namely nonalcoholic fatty liver ...
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Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid farnesoid X receptor fibroblast growth factor pathway
... The mechanisms of efficacy for fecal microbiota transplantation (FMT) in treating recurrent Clostridioides difficile infection (rCDI) remain poorly defined, with restored gut microbiota-bile acid interactions ...
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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells
... liver receptor homolog-1 (LRH-1) [12]. Liver X receptor (LXR) is a nuclear receptor, as a lipid sensor, protects cells from lipid overload and directly or indir- ectly controls ...
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Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
... nuclear receptor are already in advanced clinical trials for treatment of liver dis- eases, 27 and they have also been proposed as potential targets for therapy of several other conditions, including obesity, type ...
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Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential
... nuclear receptor FXR is classically associated with bile acid homeostasis in the body and its target genes impact on the metabolic and transporter-mediated clearance of both bile acids and their precursors ...
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Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets
... Since early signaling stimulated by GPVI was unaffected and FXR ligands were found to inhibit the function platelet responses to GPVI agonists and thrombin, we explored wheth[r] ...
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Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D
... The farnesoid X receptor belongs to the nuclear recep- tor family and is expressed in organs like the kidney, liver, adipose tissue and intestine. It influences the synthesis of bile acids, cholic ...
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<p>Evaluating the Therapeutic Potential of Cenicriviroc in the Treatment of Nonalcoholic Steatohepatitis with Fibrosis: A Brief Report on Emerging Data</p>
... Although early clinical data support direct antifibrotic effects of CVC, effects on metabolic components of NAFLD and NASH have been limited. Combination approaches to incorporate novel investigational agents tar- geting ...
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Retinoid X receptor and retinoic acid response in the marine sponge Suberites domuncula
... The results presented in this paper suggest that RXR(s), retinoic acid, and its derivatives may play important roles during morphogenesis in sponges. Identifying the proteins/ receptors which ‘transduce/facilitate’ the ...
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Pregnane X receptor activation potentiates ritonavir hepatotoxicity
... hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who were pretreated with rifampicin or efavirenz followed by RTV-containing regimens. Both ...
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The flavokawains: uprising medicinal chalcones
... that in p53-mutant-type T24 cells, flavokawain A induced a G2/M arrest instead [24]. Tang et al. [24] suggested that the molecular mechanism underlying this occurrence was through the reduction of inhibitory kinases, ...
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