Farnesoid X receptor (FXR)
Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells
... of farnesoid X receptor (FXR) and microRNA-23b-3p expression in osteosarcoma (OS) cells and miR-23b-3p specifically targets cyclin G1 ...As FXR might regulate the expression of ...
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Inhibitory Effects of Bile Acids and Synthetic Farnesoid X Receptor Agonists on Rotavirus Replication
... is farnesoid X receptor (FXR) (12, 27, ...of FXR by bile acids induces the expression of various proteins, including small heterodimer partner (SHP), which represses the expression of ...
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Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra and extrahepatic cholestasis
... Farnesoid X receptor (FXR) is a bile acid–activated transcription factor that is a member of the nuclear hormone receptor ...superfamily. Fxr-null mice exhibit a phenotype ...
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Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis
... The farnesoid X receptor (FXR) has emerged as an attractive target for the treatment of metabolic and chronic liver ...an FXR agonist currently in phase 2 clinical trials for Primary ...
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Farnesoid X receptor is essential for normal glucose homeostasis
... The farnesoid X receptor (FXR; NR1H4) is a member of the nuclear receptor superfamily that is primarily expressed in liver, kidney, and ...retinoid X receptor and binds ...
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Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis
... Nonalcoholic fatty liver disease (NAFLD) has emerged as the leading cause of chronic liver disease in the world. The clinical-histological spectrum of NAFLD includes two major phenotypes, namely nonalcoholic fatty liver ...
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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
... intestinal farnesoid X receptor (FXR) ...intestine-specific Fxr disruption had reduced hepatic triglyceride accumulation in response to a ...intestinal FXR/ceramide axis mediates ...
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Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism
... of farnesoid X receptor (FXR) signaling has beneficial effects on the development of obesity ...(8–11). FXR is a bile acid-activated nuclear receptor that regulates the ...
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Effective fecal microbiota transplantation for recurrent Clostridioides difficile infection in humans is associated with increased signalling in bile acid farnesoid X receptor fibroblast growth factor pathway
... the farnesoid X receptor (FXR)-fibroblast growth factor (FGF) ...upregulated FXR-FGF pathway, and highlight the potential systemic effect of ...
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Farnesoid X receptor associates with β-catenin and inhibits its activity in hepatocellular carcinoma
... in Farnesoid X receptor (FXR) knockout mice is not well ...with FXR by RNAi showed enhanced cell growth, migration and invasion in vitro and accelerated tumor xenografts formation in ...
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Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
... the FXR prevents fl uid secretion by inhibiting both the driving force for Cl − uptake across the baso- lateral membrane, and its exit across the apical membrane via ...of FXR activation on inhibition of ...
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Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential
... nuclear receptor FXR is classically associated with bile acid homeostasis in the body and its target genes impact on the metabolic and transporter-mediated clearance of both bile acids and their precursors ...
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TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells
... nuclear receptor activated by the FXRs that interacts physically with many nuclear receptors including ...activates FXR more efficiently than its natural ligand, the bile acids ...the FXR/SHP path- ...
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Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets
... incubation with GW4064 (1,10 M) or vehicle (containing DMSO (0.1% (v/v)) for 5 min. Blood was perfused for 10 min, after which thrombus development was assessed by measurement of fluorescence intensity. In comparison ...
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Farnesoid X receptor represses hepatic human APOA gene expression
... with FXR activators were found to have more Shp and less APOA gene ...Conversely, FXR directly repressed APOA promoter activity by binding to a DR-1 also recognized by ...by FXR (Figure ...
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Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes
... nuclear receptor farnesoid X receptor (FXR/NR1H4, in the remaining part of the manuscript FXR symbol will be used) is considered as a master regulator of BA ...homeostasis. ...
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The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines
... the Farnesoid-x-receptor (FXR) [6], Constitutive Androstane Receptor (CAR), [7], Pregnane-x-receptor (PXR) [8], liver-x-receptor (LXR) [9] and the Vitamin D ...
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<p>Evaluating the Therapeutic Potential of Cenicriviroc in the Treatment of Nonalcoholic Steatohepatitis with Fibrosis: A Brief Report on Emerging Data</p>
... Although early clinical data support direct antifibrotic effects of CVC, effects on metabolic components of NAFLD and NASH have been limited. Combination approaches to incorporate novel investigational agents tar- geting ...
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Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D
... The farnesoid X receptor belongs to the nuclear recep- tor family and is expressed in organs like the kidney, liver, adipose tissue and ...in FXR-deficient mice. But FXR is involved in ...
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Association of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease
... The farnesoid X receptor (FXR; gene symbol NR1H4) is a nuclear receptor that functions as the main sensor of intracellular bile acid levels ...Multiple FXR isoforms can be ...
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