Fc-fusion
Fc fusion mimetics
... cases, Fc recycling does not occur and effector function can be deleterious, especially in the treatment of inflammatory ...an Fc-fusion mimetic that we call RpR 2, for receptor binding ...
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Fc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias
... of fusion proteins containing the coagulation factors linked to a long-lived plasma protein such as albumin or the Fc fragment of immunoglobulin ...the Fc domain to the neonatal Fc receptor. ...
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Adjuvant-Free Immunization with Hemagglutinin-Fc Fusion Proteins as an Approach to Influenza Vaccines
... alent dose of 24 g as calculated by body surface area (24), lower than that observed for nontagged HA (30). Hemag- glutination inhibition (HAI) assays performed with guinea pig or turkey red blood cells, which contain ...
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An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques
... the Fc fusion protein studied here also produced CD4i targeting ...an Fc segment altered both the quantity and quality of the resulting serum ...
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A CD19/Fc fusion protein for detection of anti CD19 chimeric antigen receptors
... mid in 6-well tissue culture plates containing 1 ml of D10 medium. The cells were kept in transfection medium for 24 hours and then cultured in 3 ml of Pro293a ™ -CDM serum-free medium (LONZA, Basel, Switzerland) con- ...
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Protective and Therapeutic Capacity of Human Single-Chain Fv-Fc Fusion Proteins against West Nile Virus
... West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein ...
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High-Level Expression of Single-Chain Fv-Fc Fusion Protein in Serum and Egg White of Genetically Manipulated Chickens by Using a Retroviral Vector
... We report here the generation of transgenic chickens using a retroviral vector for the production of recombinant proteins. It was found that the transgene expression was suppressed when a Moloney murine leukemia ...
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Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications
... of Fc-fusion proteins has driven intense investigation for even more potent ...oligomeric Fc-based scaffold that we here show binds low-affinity inhibitory receptors (FcRL5, FccRIIb, and DC-SIGN) ...
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Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function
... FKN-Fc fusion protein exerts durable effects to enhance insulin secretion and improve glucose ...IgG Fc fragment. This chimeric FKN-Fc fusion protein dis- played a significantly ...
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Therapeutic and routine prophylactic properties of rFactor VIII Fc (efraloctocog alfa, Eloctate<sup>®</sup>) in hemophilia A
... represents the median and interquartile range, the “whiskers” represent the minimum and maximum, and the reference unity line marks the point at which PK parameters for rFviiiFc and prestudy Fviii are the same. For all ...
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LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions
... generated Fc-tagged versions of the D1 and D2 domains of the 2 LILRB1 ...the Fc fusion protein to 221 cells expressing MHCI ligands over a range of concentra- tions at 4°C as detected by flow ...UL18 ...
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Fusion Protein Comprising Factor H Domains 6 and 7 and Human IgG1 Fc as an Antibacterial Immunotherapeutic
... IgG1 Fc (FH6,7/HuFc) and tested its activity as an immunotherapeutic against Neisseria meningi- tidis, which binds FH through domains 6 and ...FH/Fc fusion proteins as anti-infective ...
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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy
... The binding of the 1843 unique potential Treg binding DARPins, expressed as mouse IgG2a Fc fusion proteins, to activated human Treg and CD4+ Teff cells was investigated using high-throug[r] ...
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Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy
... The binding of the 1843 unique potential Treg binding DARPins, expressed as mouse IgG2a Fc fusion proteins, to activated human Treg and CD4+ Teff cells was investigated using high-throug[r] ...
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Higel, Fabian Benjamin (2014): Pharmacokinetic profiling of therapeutic proteins and variants by mass spectrometry. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Fc fusion proteins are closely related to mAbs, both having an IgG related Fc part resulting in similar effector ...of Fc fusion proteins is usually a receptor or receptor domain that ...
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Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine
... U83-Fc fusion pro- tein was expressed in mammalian cells, purified from culture supernatants, subjected to affinity chromatography, and ana- lyzed by SDS-PAGE, it migrated as double bands of 38 and 40 kDa ...
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Human T-Cell Leukemia Virus Type 1 Receptor Expression among Syncytium-Resistant Cell Lines Revealed by a Novel Surface Glycoprotein-Immunoadhesin
... the Fc region of human IgG ...SU-Fc fusion protein, allowing for glycosylation of the recombinant ...SU-Fc fusion protein would also form ...
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Molecular Mechanism for LAMP1 Recognition by Lassa Virus
... an Fc portion of an antibody fused to their C termini. All Fc fusion variants were readily expressed and secreted into the media, indicating that the pro- teins were properly ...The Fc ...
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Protein engineering: emerging strategy to tackle hematological disorders
... glycol-engineering, Fc fusion, conjugation to polyethylene glycol, site directed mutagenesis or evolutionary approaches to enhance the clinical potential, which allows natural proteins to evolve as an ...
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Impact of anti CD25 monoclonal antibody on dendritic cell tumor fusion vaccine efficacy in a murine melanoma model
... in fusion cells, thereby impairing MHC class I presentation and hence the induction of CD8 + T cells by DC/tumor cell ...by fusion vaccine in the presence of IL-12 would be either a result of IFN-γ induced ...
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