Fc fusion protein
An HIV Envelope gp120-Fc Fusion Protein Elicits Effector Antibody Responses in Rhesus Macaques
... IgG Fc (gp120-Fc), but not gp120, elicited Env-specific humoral re- sponses in the absence of adjuvant, suggesting that the Fc sequence acted as an adjuvant ...bind Fc receptors, implying that ...
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A CD19/Fc fusion protein for detection of anti CD19 chimeric antigen receptors
... biotinylated Protein L, CD19-Fc fusion protein, and FITC-conjugated F(ab’)2 fragment goat anti-human IgG1 Fc, demonstrated con- sistent and sensitive detection of CAR-modified T-cells ...
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High-Level Expression of Single-Chain Fv-Fc Fusion Protein in Serum and Egg White of Genetically Manipulated Chickens by Using a Retroviral Vector
... high protein productivity in eggs, ease of and small space require- ments for breeding, similarity of the glycosylation pattern of proteins to that of humans (31), and absence of the prion ...
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Therapeutic and routine prophylactic properties of rFactor VIII Fc (efraloctocog alfa, Eloctate<sup>®</sup>) in hemophilia A
... represents the median and interquartile range, the “whiskers” represent the minimum and maximum, and the reference unity line marks the point at which PK parameters for rFviiiFc and prestudy Fviii are the same. For all ...
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Higel, Fabian Benjamin (2014): Pharmacokinetic profiling of therapeutic proteins and variants by mass spectrometry. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Fc fusion proteins are closely related to mAbs, both having an IgG related Fc part resulting in similar effector ...of Fc fusion proteins is usually a receptor or receptor domain that ...
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Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function
... FKN-Fc fusion protein exerts durable effects to enhance insulin secretion and improve glucose ...IgG Fc fragment. This chimeric FKN-Fc fusion protein dis- played a ...
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Human Herpesvirus 6 Open Reading Frame U83 Encodes a Functional Chemokine
... U83-Fc fusion protein, COS-7 cells were transfected with the plasmid together with SuperFec- tant transfection reagent ...Purified fusion proteins were equilibrated with HEPES-buffered Krebs ...
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Human T-Cell Leukemia Virus Type 1 Receptor Expression among Syncytium-Resistant Cell Lines Revealed by a Novel Surface Glycoprotein-Immunoadhesin
... the Fc region of human IgG ...SU-Fc fusion protein, allowing for glycosylation of the recombinant ...SU-Fc fusion protein would also form ...binant protein and to ...
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LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions
... generated Fc-tagged versions of the D1 and D2 domains of the 2 LILRB1 ...the Fc fusion protein to 221 cells expressing MHCI ligands over a range of concentra- tions at 4°C as detected by flow ...
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Fc fusion mimetics
... a Fc-fusion protein that is used to treat age related macular degeneration (AMD) by binding to vascular endothelial growth factor (VEGF) in the back of the ...eye. Fc-fusion proteins ...
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Fc-fusion technology and recombinant FVIII and FIX in the management of the hemophilias
... genetic fusion to plasma proteins is one of the most promising strategies developed in order to produce long-acting FVIII and ...of fusion constructs of these coagulation proteins with either albumin or ...
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Immobilisation of active enzymes on novel GFP protein particles : a thesis submitted in complete fulfilment of the requirements of the degree of Master of Science in Microbiology at Massey University, Palmerston North, New Zealand
... GFP protein particle (GFP particle) that not only exhibited fluorescence, but was also able to display functional antibody and ligand binding ...of fusion proteins. These fusion proteins in turn ...
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Recombinant human CD19L sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia
... genetic fusion of CD19L to sTRAIL would markedly enhance the potency of sTRAIL and act as a potent inducer of apoptosis for BPL cells due to the membrane anchoring of sTRAIL and the simultaneous activation of the ...
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O Mannosylation of α-Dystroglycan Is Essential for Lymphocytic Choriomeningitis Virus Receptor Function
... mannosyl carbohydrates (12). The LCMV binding site on ␣ -DG has been mapped between the N-terminal globular do- main and part of the mucin-like region (32). Previously, it was suggested that the receptor-virus ...
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A transgenic tool to assess Anopheles mating competitiveness in the field
... Plugin-tdTomato fusion could be reliably detected with- out sacrificing the ...fluorescent protein, but this signal, likely derived from plug lipids, is only reliably detected for 2 hours post mating ...
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Polybasic KKR Motif in the Cytoplasmic Tail of Nipah Virus Fusion Protein Modulates Membrane Fusion by Inside-Out Signaling
... faster fusion kinetics and display increased resistance to heptad repeat peptide inhibition (1, ...during fusion pore formation, resulting in increased or decreased fusion kinetics, respectively ...
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Adjuvant-Free Immunization with Hemagglutinin-Fc Fusion Proteins as an Approach to Influenza Vaccines
... human Fc domain flanking directional genomic restriction sites for high-throughout baculovirus expression as de- scribed elsewhere (22, ...HA-HuFC fusion protein present in the supernatant was ...
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Novel Fc gamma receptor I family gene products in human mononuclear cells
... second Fc gamma RI family gene, termed Fc gamma ...by Fc gamma RI specific monoclonal antibodies when transfected into COS-7 ...affinity Fc gamma receptor that may play an important role in ...
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7,8 dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF implicated human disorders
... His-tagged fusion protein of human TrkB-ECD (C32-H430), and human IgG1 that can specifically neutralize BDNF’s agonistic effect on TrkB, we demonstrated that these agents can antagonize 7,8-DHF’s ...
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Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation
... for FC cDNA, whereas the rest had a deletion of nucleotides 580–584 in exon ...in FC mRNA, which is predicted to cause the formation of a truncated protein that is 208 amino acids long (Table ...the ...
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