Fcγ receptors
Fcγ Receptors Contribute to the Antiviral Properties of Influenza Virus Neuraminidase Specific Antibodies
... ABSTRACT Influenza virus neuraminidase (NA) has been under intense study re- cently as a vaccine antigen, yet there remain unanswered questions regarding the immune response directed toward NA. Antibodies (Abs) that can ...
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Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
... Fcg receptors bind immunoglobulin G (IgG) and trigger signal transduction events leading to microglial activa- tion ...Fcg receptors in PD: in postmortem human brain, PD is associated with increased binding ...
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Fcγ Receptors Play a Dominant Role in Protective Tumor Immunity against a Virus-Encoded Tumor-Specific Antigen in a Murine Model of Experimental Pulmonary Metastases
... Fc receptors (Fc ␥ Rs) comprise a subset of surface molecules displayed on immunologic effector cell populations that mediate functions via intracellular signal- ing cascades due to antibody-antigen cross-linking ...
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A Panel of IgG1 b12 Variants with Selectively Diminished or Enhanced Affinity for Fcγ Receptors To Define the Role of Effector Functions in Protection against HIV
... tency similar to wt b12. To evaluate the importance of the different receptors, we added a CD16 or CD32 blocking anti- body together with wt b12. As expected, blocking Fc ␥ RIIa also abolished all phagocytosis, ...
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Autoantibody mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade
... Consistent with our prior report that arthritis in K/ BxN mice depends on C5 but not FcRg [22], we found that K/BxN mice lacking both C5 and FcRg developed less severe arthritis than controls (Figure 3b). In the ankles ...
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Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion related acute lung injury
... Discussion The major findings of this study are that a the transfusion of an MHC I mAb to mice with the cognate antigen produced ALI and mortality in a clinically relevant time period; b[r] ...
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Effects of Androgen Treatment on Expression of Macrophage Fcγ Receptors
... Guinea pig macrophages express two classes of Fc␥Rs: Fc␥R1,2 and Fc␥R2 (23). We examined the effects of andro- gens on the expression of both Fc␥R1,2 and Fc␥R2 by isolated splenic macrophages using flow cytometry with ...
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Association between monocyte Fcγ subclass expression and acute coronary syndrome
... scavenger receptors SR-A and CD36 have not demonstrated inter-individual varia- bility in their basal expression levels (prior to initial uptake of OxLDL or differentiation to macrophages) [23,24], the variable ...
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Modulation of tumor growth by inhibitory Fcγ receptor expressed by human melanoma cells
... The efficacy of anti-tumor IgG reflects the balance between opposing signals mediated by activating and inhibitory Fcγ receptors (FcγRs) expressed by effector cells. Here, we show that human malignant ...
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A Study of Differential Glycosylation of IgG on Fcγ Receptor Mediated Neutrophil Recruitment Model of SLE Nephritis
... classical Fcγ Receptors (FcγRs): FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, and FcγRIIIB and a single receptors can possess high and low affinity interactions, where the low affinity characteristic ...
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Local IL 13 gene transfer prior to immune complex arthritis inhibits chondrocyte death and matrix metalloproteinase mediated cartilage matrix degradation despite enhanced joint inflammation
... During immune-complex-mediated arthritis (ICA), severe cartilage destruction is mediated by Fcγ receptors (FcγRs) (mainly FcγRI), cytokines (e.g. IL-1), and enzymes (matrix metalloproteinases (MMPs)). ...
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In Search for Pheromone Receptors: Certain Members of the Odorant Receptor Family in the Desert Locust Schistocerca gregaria (Orthoptera: Acrididae) Are Co-expressed with SNMP1
... pheromone receptors implying an interplay between SNMP1 and receptors for pheromones ...of receptors appeared to be unique due to its more basal position in the ...pheromone receptors in moth ...
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Modulation of CaV1 3b L type calcium channels by M1 muscarinic receptors varies with CaVβ subunit expression
... Abstract Objectives: We examined whether two G protein-coupled receptors GPCRs, muscarinic M1 receptors M1Rs and dopaminergic D2 receptors D2Rs, utilize endogenously released fatt[r] ...
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Deregulation of innate and adaptive immune responses in human papillomavirus infection and cancer
... contained cancer-related genes including tumor-promoting cyto- kines/chemokines and their receptors, e.g. CXCR7, of which the expression was higher in HPV-positive KCs irrespective of poly(I:C) stimulation. Many ...
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Role of Membrane Lipids in the Organization and Function of the Serotonin1A Receptor
... Biological membranes are complex non‐covalent assemblies of a diverse variety of lipids and proteins that allow cellular compartmentalization. The cell membrane imparts identity to a cell and is proposed to be utmost ...
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Insulin Receptors
... Much of the emphasis in the pathogenesis of diabetes mellitus has justifiably been placed on the endocrine gland, the pancreas. Extensive studies on the biosynthes[r] ...
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Early Steps of Clathrin-Mediated Endocytosis Involved in Phagosomal Escape of Fcγ Receptor-Targeted Adenovirus
... specific receptors and mem- branes in all eucaryotic ...the receptors, it leads to temporally and spatially controlled internalization and activation or to constitutive uptake and ...transmembrane ...
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Identification and Expression of Human Cytomegalovirus Transcription Units Coding for Two Distinct Fcγ Receptor Homologs
... The common Fc␥ binding property and plasma membrane expression link HCMV-encoded vFc␥Rs with cFc␥Rs, i.e., Fc␥RI, which is the high-affinity receptor for monomeric IgG, and Fc␥RII and Fc␥RIII, which are low-affinity ...
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Liver X receptor opens a new gateway to StAR and to steroid hormones
... Liver X receptors (LXRs) broadly limit cholesterol accumulation by regu- lating expression of genes involved in cholesterol efflux and storage. In this issue of the JCI, Cummins et al. report that LXRα is involved ...
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Adenovirus Receptors
... with receptors on the cell ...bind receptors is somehow maintained despite sequence variation resulting from immu- nologic pressures ...other receptors (see ...
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