FGF signalling
FGFRL1 is a neglected putative actor of the FGF signalling pathway present in all major metazoan phyla
... of FGF signalling [23], and in Nematostella, expression of NvSprouty overlaps with that of several FGF ...the FGF-Sprouty feedback loop is conserved between cnidarian and bilaterian animals ...
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FGF signalling generates ventral telencephalic cells independently of SHH
... Of the three FGF receptor genes expressed in telencephalic precursor cells, Fgfr1 plays a dominant role. Telencephalons that are deficient for both copies of Fgfr2 and Fgfr3 but that retain only one copy of Fgfr1 ...
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FGF signalling and the mechanism of mesoderm spreading in Drosophila embryos
... Ras/MAPK signalling, but regulates a process that is not well defined to inhibit convergent extension movements (Nutt et ...the FGF-dependent pathways that regulate differentiation and morphogenesis can be ...
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Fgf signalling controls the dorsoventral patterning of the zebrafish embryo
... We speculated that the weak dorsalisation of Spry4 or Sef-depleted embryos may be due to the existence of additional modulators of Fgf signalling. In accordance with this hypothesis, we isolated a second ...
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FGF signalling: diverse roles during early vertebrate embryogenesis
... several signalling pathways (reviewed by Levine and Brivanlou, 2007; Stern, ...2005). FGF signalling is one pathway implicated in neural induction, based on evidence obtained from several model ...
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Fgf signalling controls diverse aspects of fin regeneration
... of signalling molecules such as insulin-like growth factor (Chablais and Jazwinska, 2010), Notch (Grotek et ...that Fgf signalling is necessary for fin regeneration (Poss et ...essential Fgf ...
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Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish
... To form proneuromasts, groups of cells in the migrating pLLP coordinately constrict their apical side to form radially organized clusters or rosettes. This process is controlled by FGF signalling in the ...
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FGF signalling controls formation of the apical sensory organ in the cnidarian Nematostella vectensis
... identify signalling molecules that are involved in the embryonic patterning of Nematostella, we identified and isolated the complete set of 15 homologous transcripts of Fibroblast growth factors (FGFs) and the ...
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Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum
... as FGF antagonists in mes/r1. Next, we tested whether increased FGF signalling affected gene expression patterns in the mes/r1 ...2005). FGF signals can also repress the mesencephalic marker ...
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Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS domain transcription factor Etv5b
... when Fgf signalling is required for 5-HT neuron formation, we blocked Fgf signalling in wild-type embryos at different developmental intervals chosen to cover phases of proliferation, ...
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Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium
... or Fgf signalling elicits backward or forward migration of SPCs, respectively, and that inhibition of Fgf signalling blocks the backward migration that would otherwise occur in the absence of ...
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Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition
... that FGF signalling plays a positive role in this ...antimorphic FGF receptors and a pharmacological FGFR inhibitor, we found that the earliest steps of neural tissue development critically and ...
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Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post embryonic brain
... the FGF pathway (Ghabrial et ...two FGF ligands in Drosophila, Pyramus (Pyr) and Thisbe (Ths), which have overlapping functions in embryonic mesoderm specification (Stathopoulos et ...several FGF ...
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Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants
... that Fgf signalling is dispensable for cerebellar cell differentiation in the absence of Otx ...of Fgf signalling from the IsO is neither to induce r1 nor cerebellar cell identities but to ...
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Hindbrain patterning requires fine tuning of early krox20 transcription by Sprouty 4
... of FGF signalling As discussed above, we propose that segment formation in the r3- r5 region is based on a bistable cell-fate choice that is dependent on the activation (or not) of the Krox20 positive ...
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A balance of FGF, BMP and WNT signalling positions the future placode territory in the head
... WNT signalling: activation of the WNT pathway expands the crest territory at the expense of the pre-placodal ...region. FGF signalling cooperates with BMP and WNT antagonists to induce the ...
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Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domains
... 2002). Fgf may also have graded activity during blastula and gastrula stages: high vegetally and low at the animal pole (iii,iv) (Figs 2, 3) (Furthauer et ...by Fgf-dependent promotion of prospective neural ...
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Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation
... of Fgf and retinoid signalling centres persists as the body axis is generated progressively from these caudal tissues, with cells experiencing Fgf and subsequently retinoid ...manipulate ...
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Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development
... the Fgf proteins regulate the Spry-mediated antagonism by inducing degradation of Spry proteins, which then restores the sensitivity of the extracellular signal-regulated kinase (ERK) to Fgf ...
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Expression of osterix Is Regulated by FGF and Wnt/β-Catenin Signalling during Osteoblast Differentiation
... Wnt signalling via the β-Catenin pathway has more recently been identified as a key regula- tor of osteoblastogenesis [21 – ...with FGF signalling, a consensus has not emerged regard- ing the precise ...
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