FGFR2 gene
Original Article Polymorphism in the second intron of the FGFR2 gene rs1219648 associated with the early-onset breast cancer in Turkish population
... the FGFR2 gene have been associated with postmenopausal breast cancer patients in many ...on FGFR2 rs1219648 polymorphism in early-onset breast cancer in Turkish ...
6
Lack of Association between Polymorphisms in rs2981582, rs2420946, rs17102287, rs1219648, rs2981578, and rs17542768 Sites of FGFR2 Gene with Breast Cancer in the Population of Kazakhstan
... Worldwide, breast cancer (BC) is the most common invasive cancer in women. Fibroblast growth factor recep- tor 2 (FGFR2) is a tyrosine kinase receptor that is a member of the family of individually distinct ...
5
Molecular analysis of exon 7 of the fibroblast growth factor receptor 2 (FGFR2) gene in an Indonesian patient with Apert syndrome: a case report
... Case presentation: A 27-year-old Javanese man presented borderline intellectual functioning and striking dysmorphisms. A clinical diagnosis of Apert syndrome was previously made based on these clinical features. ...
6
TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk
... of FGFR2 gene occurs in a small subset of breast cancer ...of FGFR2 rs2981582 are associ- ated with reduced risk of breast ...of FGFR2 rs2981582 is associated with increased breast cancer risk ...
6
Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
... in FGFR2 have been associated with a number of human cancers (Jang et ...the fgfr2 gene are seen in congenital skeletal disorders (Wilkie et ...Alternative gene-splicing events provide ...
12
Advances and challenges in targeting FGFR signalling in cancer.
... SLC45A3-FGFR2 gene fusion was identified in a patient with prostate cancer 52 ...SLC45A3-FGFR2 gene fusion represents a unique pathogenic mechanism, in which the entire open reading frame of ...
38
FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype
... of FGFR2 has pre- viously been reported in up to 12% of breast tumours [13,14], we did not observe this phenomenon in the 40 tumours that we ...of FGFR2 was related to genotype. If overexpression of ...
7
FGFR2 amplification has prognostic significance in gastric cancer: results from a large international multicentre study
... for gene copy-number analysis. Full sections were cut from 26 UK FGFR2-amplified GC specimens to assess amplification heterogeneity within individual ...histopathologist. FGFR2 FISH. The FGFR2 ...
9
Silencing of the Pink1 Gene Expression by Conditional RNAi Does Not Induce Dopaminergic Neuron Death in Mice
... silencing gene expression in transgenic mice and inducing phenotypes of the gene ...Id4 gene induces de- velopmental defects in kidney [12]; silencing of Fgfr2 gene causes embryonic ...
9
Fibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis
... (FGFR2) gene is perhaps the most extensively studied gene that is mutated in various craniosynostotic syndromes including Crouzon, Apert, Pfeiffer, Antley-Bixler, Beare-Stevenson cutis gyrata, ...
10
Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM 52PE
... and FGFR2 genes are expressed in both normal and breast cancer tissues [24], and alterations, including amplification and overexpression of FGFR1 and FGFR2, have previously been reported in 5–10% of primary ...
10
The mouse seminal vesicle shape mutation is allelic with Fgfr2
... for Fgfr2 function were evaluated in several ...of FGFR2 and observed a banding pattern in both wild-type and svs mutant seminal vesicles similar to that previously reported for this antibody in experiments ...
9
Tissue specific roles of Fgfr2 in development of the external genitalia
... of Fgfr2 EctoΔ mutants suggests that the cells are able to sense increases in mechanical force; however, the absence of increased β -catenin suggests an inability of the ectodermal cells to respond to increased ...
10
Gatekeeper Mutations and Intratumoral Heterogeneity in FGFR2-Translocated Cholangiocarcinoma.
... Using molecular barcoded sequencing on progression plasma DNA and tumour, they describe the acquisition of polyclonal FGFR2 mutations, with a gatekeeper p.V564F mutation found in all three patients. Mutations at ...
7
<p><em>FGFR2-BICC1</em>: A Subtype Of <em>FGFR2</em> Oncogenic Fusion Variant In Cholangiocarcinoma And The Response To Sorafenib</p>
... kinases. FGFR2 have been reported as a novel target for tyrosine kinase inhibitor (TKI) ...a FGFR2-rearranged gene fusion and was sensitive to TKI-sorafenib, a multi-targeted small ...
5
FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma
... of FGFR2 has focused largely on relatively uncommon tumors that exhibit activating somatic mutations resulting in ligand-independent signaling ...that FGFR2 upregulation and activat- ed paracrine signaling ...
15
Initiation of vertebrate limb development
... Hox gene expression characteristic of more a proximal ...Hox gene expression from "tail" to "leg", which will almost certainly involve downregulation of group 13 Hox ...Hox gene ...
202
Whole exome sequencing of adenoid cystic carcinoma
... suppressor gene (8, ...NOTCH gene mutations in ACC is not easily discerned from the muta- tional pattern and may be different depending on the context of other cancer mutations in ...
5
ADAR1 silencing-induced HUVEC apoptosis is mediated by FGFR2 under hypoxia stress
... As we have proved that knockdown ADAR1 could increase cell apoptosis and decrease cell permeability, this situation is coincided with the function of FGFR2 in HUVECs. To further investigate the connectivity of ...
9
GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients
... the FGFR2 locus and their influence on breast cancer were provided, particularly regarding tumor ER ...in FGFR2 and ER status in breast cancer was stronger among patients with HER2− ...
7