fibroblast growth
Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival
... of fibroblast growth factors (FGFs) to promote receptor dimerization, autophosphorylation and activation of signaling pathways governing various biological responses involving cell differentiation, ...
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Role of fibroblast growth factors in bone regeneration
... FGF: Fibroblast growth factor; FGFR: Fibroblast growth factor receptor; GSK-3: Glycogen synthase kinase-3; iFGF: Intracellular fibroblast growth factor; Ig: Immunoglobulin; MSC: ...
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Fibroblast growth factors
... Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to ...
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Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy
... Abstract: Fibroblast growth factor receptors (FGFRs) are attractive candidate cancer therapy targets as they are overexpressed in multiple types of tumors, such as breast, prostate, bladder, and lung ...of ...
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Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Hemodialysis Patients
... Background: Left ventricular hypertrophy (LVH) is a common cardiovascular complication and an independent risk factor for cardiovascular death in hemodialysis (HD) patients. Previous studies have shown that ...
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Fibroblast growth factor 19 entry into brain
... Mouse fibroblast growth factor (FGF)-15 and its human ortholog FGF19 are endocrine hormones mainly pro- duced by the ileum to inhibit bile acid synthesis and regulate the metabolism of lipids and glucose ...
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The role of heparan sulfates in fibroblast growth factor action
... 1989: Heparin-derived oligosaccharides: affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells.. 1989: Basic fibroblast grow[r] ...
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Analysis of fibroblast growth factor-heparin interactions
... of fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF ...
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Molecular and clinical significance of fibroblast growth factor 2 (FGF2 /bFGF) in malignancies of solid and hematological cancers for personalized therapies
... Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology. Mammalian FGF family members participate in multiple signaling pathways by binding to heparan sulfate and FGF receptors ...
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Fibroblast growth factor receptors and skeletogenesis
... It was thought that the expanding brain, by inducing a raised intracranial pressure affecting the soft tissues, triggered the growth of the bone at the OFs. However, there is a delay of 5-10 years between ...
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Fibroblast growth factor 2 orchestrates angiogenic networking in non GIST STS patients
... a growth factor on the tumor cells in a paracrine/autocrine fashion, activating intracellular pathways and ultimately leading cells to proliferate, avoid apoptosis or become insensitive to antigrowth signals ...
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The Characterization of the Fibroblast Growth Factor Receptor Substrate 3 and its role in Regulating Microtubule Dynamics and Molecular Transport in the Brain
... the cortex. Synaptogenesis is the formation of synapses between neurons and occurs as an integration of signaling, recognition, adhesion and protein targeting. This process begins with axonal guidance to the correct ...
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Protein synthesis and secretion in human mesenchymal cells derived from bone marrow, adipose tissue and Wharton’s jelly
... Acidic fibroblast growth factor; AT-MSC: Adipose tissue-derived MSC; bFGF: Basic fibroblast growth factor; BM-MSC: Bone marrow-derived MSC; DMEM: Dulbecco ’ s modified Eagle media; EGF: ...
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Mesenchymal stem cells enhance ovarian cancer cell infiltration through IL6 secretion in an amniochorionic membrane based 3D model
... basic Fibroblast Growth Factor (bFGF) (Peprotech), 20 ng/ml Epidermal Growth Factor (EGF) (Peprotech), 5 μg/ml Insu- lin (Sigma), 2% B27 supplements (Invitrogen) and 4% base- ment matrigel (BD ...
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Initiation of vertebrate limb development
... in Fibroblast growth factors (FGFs) and placed in prospective flank of chick embryos induce formation of ectopic limb buds, which contain their own signaling regions and develop into complete ...
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Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
... platelet-derived growth factor (PDGF)/PDGF receptor pathway is thought to play a critical role in fibrogenesis of the ...Other growth factors, including fibroblast growth factor and vascu- lar ...
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Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis
... GFs: growth factors; GF: growth factor; NTFs: neurotrophic factors; bFGF: basic fibroblast growth factor; NGF: nerve growth factor; DPN: diabetic peripheral neuropathy; PNS: peripheral ...
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Intrauterine growth restriction and placental angiogenesis
... endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental ...intrauterine growth ...
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Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II
... hypertrophic growth of vascular smooth muscle cells (VSMC). Accompanying this growth is the induction of the expression of growth-related protooncogenes (c-fos, c-jun, and c-myc), as well as the ...
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Potent mitogenic effects of parathyroid hormone (PTH) on embryonic chick and rabbit chondrocytes Differential effects of age on growth, proteoglycan, and cyclic AMP responses of chondrocytes to PTH
... The effect of PTH on chondrocyte proliferation as a function of cartilage age was examined. PTH[1-34] induced a 12- to 15-fold increase in the efficiency of colony formation in soft agar by chondrocytes from embryonic ...
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